ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count geneSymbol ErichmentScore -log10(P.adj) type hsa00071 Fatty acid degradation 9/184 43/8081 3.91313337544729e-07 0.000100567527748995 9.3915201010735e-05 224/125/8310/51/30/223/34/131/501 9 ALDH3A2/ADH1B/ACOX3/ACOX1/ACAA1/ALDH9A1/ACADM/ADH7/ALDH7A1 9.19223963599596 3.998 KEGG hsa00590 Arachidonic acid metabolism 9/184 61/8081 8.45373542759486e-06 0.00108630500244594 0.00101444825131138 874/2878/2053/1573/239/1559/1571/5742/247 9 CBR3/GPX3/EPHX2/CYP2J2/ALOX12/CYP2C9/CYP2E1/PTGS1/ALOX15B 6.4797754811119 2.964 KEGG hsa00410 beta-Alanine metabolism 6/184 30/8081 4.83800439256396e-05 0.00414455709629646 0.00387040351405117 224/8310/51/223/18/501 6 ALDH3A2/ACOX3/ACOX1/ALDH9A1/ABAT/ALDH7A1 8.78369565217391 2.383 KEGG hsa01040 Biosynthesis of unsaturated fatty acids 5/184 27/8081 0.000311356672923631 0.0200046662353433 0.0186814003754179 8310/51/30/79071/6785 5 ACOX3/ACOX1/ACAA1/ELOVL6/ELOVL4 8.13305152979066 1.699 KEGG hsa00280 Valine, leucine and isoleucine degradation 6/184 48/8081 0.000711862519504326 0.0353687360783171 0.0330291698785841 224/30/223/34/18/501 6 ALDH3A2/ACAA1/ALDH9A1/ACADM/ABAT/ALDH7A1 5.4898097826087 1.451 KEGG hsa00830 Retinol metabolism 7/184 68/8081 0.000849890533892218 0.0353687360783171 0.0330291698785841 125/1562/1559/10170/131/1577/145226 7 ADH1B/CYP2C18/CYP2C9/DHRS9/ADH7/CYP3A5/RDH12 4.52101982097187 1.451 KEGG hsa04726 Serotonergic synapse 9/184 115/8081 0.00119485705660135 0.0353687360783171 0.0330291698785841 1573/3709/1562/239/1559/5742/1843/247/5595 9 CYP2J2/ITPR2/CYP2C18/ALOX12/CYP2C9/PTGS1/DUSP1/ALOX15B/MAPK3 3.43709829867675 1.451 KEGG hsa00982 Drug metabolism - cytochrome P450 7/184 72/8081 0.00119657574426265 0.0353687360783171 0.0330291698785841 4258/125/2327/1559/1571/131/1577 7 MGST2/ADH1B/FMO2/CYP2C9/CYP2E1/ADH7/CYP3A5 4.2698520531401 1.451 KEGG hsa00920 Sulfur metabolism 3/184 10/8081 0.0012385938704469 0.0353687360783171 0.0330291698785841 23474/7263/8991 3 ETHE1/TST/SELENBP1 13.1755434782609 1.451 KEGG hsa00340 Histidine metabolism 4/184 22/8081 0.00137999576635924 0.0354658911954326 0.0331198983926219 443/224/223/501 4 ASPA/ALDH3A2/ALDH9A1/ALDH7A1 7.98517786561265 1.45 KEGG hsa01212 Fatty acid metabolism 6/184 57/8081 0.00177769316025548 0.0409962819036099 0.0382844655909197 8310/51/30/79071/6785/34 6 ACOX3/ACOX1/ACAA1/ELOVL6/ELOVL4/ACADM 4.62299771167048 1.387 KEGG hsa00980 Metabolism of xenobiotics by cytochrome P450 7/184 78/8081 0.00191422327954599 0.0409962819036099 0.0382844655909197 874/4258/125/1559/1571/131/1577 7 CBR3/MGST2/ADH1B/CYP2C9/CYP2E1/ADH7/CYP3A5 3.94140189520624 1.387 KEGG R-HSA-6798695 Neutrophil degranulation 29/257 479/10554 5.3215270272351e-06 0.00191398306479829 0.00184040056497813 10321/1675/2934/55/9145/25840/3579/10493/23593/10043/5646/30/1992/55313/634/23218/1476/978/5269/10396/4680/8895/6286/3958/6947/6280/5768/383/258010 29 CRISP3/CFD/GSN/ACPP/SYNGR1/METTL7A/CXCR2/VAT1/HEBP2/TOM1/PRSS3/ACAA1/SERPINB1/CPPED1/CEACAM1/NBEAL2/CSTB/CDA/SERPINB6/ATP8A1/CEACAM6/CPNE3/S100P/LGALS3/TCN1/S100A9/QSOX1/ARG1/SVIP 2.48625947377399 2.718 Reactome R-HSA-8978868 Fatty acid metabolism 16/257 177/10554 6.36932800265655e-06 0.00191398306479829 0.00184040056497813 1580/8309/2053/224/8310/1573/51/30/3248/79071/239/1559/6785/34/5742/247 16 CYP4B1/ACOX2/EPHX2/ALDH3A2/ACOX3/CYP2J2/ACOX1/ACAA1/HPGD/ELOVL6/ALOX12/CYP2C9/ELOVL4/ACADM/PTGS1/ALOX15B 3.71219415682912 2.718 Reactome R-HSA-211945 Phase I - Functionalization of compounds 12/257 107/10554 1.07047012746506e-05 0.00214450848868834 0.00206206350869586 874/1580/125/2327/1573/1562/8824/1559/1571/5742/131/1577 12 CBR3/CYP4B1/ADH1B/FMO2/CYP2J2/CYP2C18/CES2/CYP2C9/CYP2E1/PTGS1/ADH7/CYP3A5 4.60554929270155 2.669 Reactome R-HSA-9018677 Biosynthesis of DHA-derived SPMs 5/257 17/10554 4.00909751787456e-05 0.00602366902060653 0.00579209088766614 2053/3248/239/1559/1571 5 EPHX2/HPGD/ALOX12/CYP2C9/CYP2E1 12.0782787823301 2.22 Reactome R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs) 5/257 19/10554 7.23851151906927e-05 0.00840735799522039 0.00808413966087397 2053/3248/239/1559/1571 5 EPHX2/HPGD/ALOX12/CYP2C9/CYP2E1 10.806881015769 2.075 Reactome R-HSA-2142753 Arachidonic acid metabolism 8/257 59/10554 8.39336904680904e-05 0.00840735799522039 0.00808413966087397 1580/2053/1573/3248/239/1559/5742/247 8 CYP4B1/EPHX2/CYP2J2/HPGD/ALOX12/CYP2C9/PTGS1/ALOX15B 5.56829123524369 2.075 Reactome R-HSA-211859 Biological oxidations 16/257 223/10554 0.000109523492789732 0.00940337416666125 0.00904186429196432 874/1580/4258/125/2327/1573/6820/1562/8824/1559/1571/5742/131/1577/1836/79094 16 CBR3/CYP4B1/MGST2/ADH1B/FMO2/CYP2J2/SULT2B1/CYP2C18/CES2/CYP2C9/CYP2E1/PTGS1/ADH7/CYP3A5/SLC26A2/CHAC1 2.94645007066706 2.027 Reactome R-HSA-211981 Xenobiotics 5/257 24/10554 0.000239484093966473 0.0179912425592312 0.0172995746825781 1573/1562/1559/1571/1577 5 CYP2J2/CYP2C18/CYP2C9/CYP2E1/CYP3A5 8.55544747081712 1.745 Reactome R-HSA-6809371 Formation of the cornified envelope 11/257 129/10554 0.000303625306252389 0.0202754232286318 0.0194959407172587 11005/196374/2125/7051/26085/2312/43849/3713/3860/6707/6698 11 SPINK5/KRT78/EVPL/TGM1/KLK13/FLG/KLK12/IVL/KRT13/SPRR3/SPRR1A 3.50176454619491 1.693 Reactome R-HSA-390918 Peroxisomal lipid metabolism 5/257 29/10554 0.000605789976932768 0.0364079776136594 0.0350082839301147 8309/224/8310/51/30 5 ACOX2/ALDH3A2/ACOX3/ACOX1/ACAA1 7.08037032067624 1.439 Reactome R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 7/257 63/10554 0.00080879388129504 0.0441895566053017 0.0424907024718638 10020/5372/55577/2762/55343/6484/55808 7 GNE/PMM1/NAGK/GMDS/SLC35C1/ST3GAL4/ST6GALNAC1 4.56290531776913 1.355 Reactome