| Gene/Event | Cancer Type | Patient | Variant | Mutation Level |
|---|---|---|---|---|
| POLE2 | Breast Cancer | p123_case4 | p.T245S | Private mutation |
| POLE2 | Colorectal Cancer | p034_MSU1 | Chr14:50136305:C>T | Trunk mutation |
| POLE2 | Esophageal Squamous Cell Carcinoma | p124_ESCC019 | p.I178I | Private mutation |
| POLE2 | Gastric Adenocarcinoma | p011_MSI-H2 | p.H356Q | Trunk mutation |
| POLE2 | Gastric Adenocarcinoma | p011_MSI-H2 | p.K126K | Trunk mutation |
| POLE2 | Glioma | p168_P01 | p.A239A | Branch mutation |
| POLE2 | Intrahepatic Cholangiocarcinoma | p080_ICC772 | Chr14:50136301:C>A | Trunk mutation |
| POLE2 | Clear Cell Renal Cell Carcinoma | p019_RMH008 | Chr14:50141129:p.I>F | Branch mutation |
| POLE2 | Renal Cell Carcinoma | p073_RCC10 | Chr14:50141129:T>A | Branch mutation |