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Gene/Event	Cancer Type	Patient	Variant	Mutation Level
SPEN	Bladder Cancer	p076_DFCI-33	p.R1241Q	Trunk mutation
SPEN	Bladder Cancer	p076_DFCI-33	p.Q1764H	Private mutation
SPEN	Bladder Cancer	p076_FCCC-026	p.E3593K	Private mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.Q2244H	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.S324L	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.Q369*	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.E2149K	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.E2358K	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.E2070K	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.S1821N	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.A2251P	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.L380V	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.D2145H	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.E2016*	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.E2130K	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0255	p.E2064Q	Trunk mutation
SPEN	Bladder Cancer	p076_MSK-0331	p.K1496Q	Private mutation
SPEN	Bladder Cancer	p076_MSK-0820	p.D2401N	Trunk mutation
SPEN	Breast Cancer	p037_ER1	del	Branch mutation
SPEN	Breast Cancer	p037_ER2	p.E2151K	Private mutation
SPEN	Breast Cancer	p037_ER3	p.K1838X	Branch mutation
SPEN	Breast Cancer	p131_case5	p.S2684Hfs*96	Trunk mutation
SPEN	Breast Cancer	p131_case5	p.S2684Hfs*96	Trunk mutation
SPEN	Breast Cancer	p131_case5	p.S2684Hfs*96	Trunk mutation
SPEN	Carcinosarcoma of the uterus and ovary	p009_SAR24	-	Private mutation
SPEN	Colorectal Cancer	p004_CRC_A04	Chr1:16260109:G>A	Private mutation
SPEN	Colorectal Cancer	p014_CRC3	p.Y564H	Branch mutation
SPEN	Colorectal Cancer	p034_MSU1	Chr1:16260896:G>A	Trunk mutation
SPEN	Colorectal Cancer	p034_MSU1	Chr1:16262141:C>T	Trunk mutation
SPEN	Colorectal Cancer	p034_MSU1	Chr1:16262659:C>T	Trunk mutation
SPEN	Colorectal Cancer	p034_MSU2	Chr1:16256232:C>T	Private mutation
SPEN	Colorectal Cancer	p034_MSU2	Chr1:16259269:C>T	Private mutation
SPEN	Colorectal Cancer	p040_case9	Chr1:16258440:G>A	Trunk mutation
SPEN	Colorectal Cancer	p069_p13	p.Q1595K	Private mutation
SPEN	Colorectal Cancer	p104_UC06	p.G1506G	Private mutation
SPEN	Colorectal Cancer	p155_p335	p.E2149D	Private mutation
SPEN	Esophageal Squamous Cell Carcinoma	p124_ESCC005	p.P1953S	Private mutation
SPEN	Esophageal Squamous Cell Carcinoma	p124_ESCC005	p.R1952S	Private mutation
SPEN	Esophageal Squamous Cell Carcinoma	p124_ESCC009	p.L2518V	Trunk mutation
SPEN	Esophageal Squamous Cell Carcinoma	p124_ESCC009	p.S2481*	Trunk mutation
SPEN	Esophageal Squamous Cell Carcinoma	p124_ESCC010	p.Q253E	Trunk mutation
SPEN	Esophageal Squamous Cell Carcinoma	p124_ESCC012	p.L3050L	Branch mutation
SPEN	Esophageal Squamous Cell Carcinoma	p124_ESCC012	p.D1221N	Private mutation
SPEN	Esophageal Squamous Cell Carcinoma	p124_ESCC015	p.L1030L	Trunk mutation
SPEN	Esophageal Squamous Cell Carcinoma	p124_ESCC022	p.L1454L	Private mutation
SPEN	Esophageal Squamous Cell Carcinoma	p124_ESCC025	p.W1340C	Branch mutation
SPEN	Esophageal Squamous Cell Carcinoma	p128_P03	Chr1:16259654:G>A	Private mutation
SPEN	Esophageal Squamous Cell Carcinoma	p128_SP03	Chr1:16259654:G>A	Private mutation
SPEN	Esophageal Squamous Cell Carcinoma	p139_EC1071	p.V3496M	Private mutation
SPEN	Gastric Adenocarcinoma	p011_MSS1	p.A2800T	Private mutation
SPEN	Gastric Carcinoma	p083_GAC	Chr1:16255163:C>T	Trunk mutation
SPEN	Gastric Carcinoma	p106_GC06	p.V2175M	Trunk mutation
SPEN	Gastric Carcinoma	p106_GC09	p.P2240P	Private mutation
SPEN	Glioblastoma	p070_HGG2	Chr1:16259080:G>T	Private mutation
SPEN	Glioblastoma	p079_a	p.P3434S	Branch mutation
SPEN	Glioblastoma	p113_case05	p.R806Tfs*14	Private mutation
SPEN	Glioblastoma	p113_case07	p.G1212D	Private mutation
SPEN	Glioblastoma	p113_case07	p.P1890L	Private mutation
SPEN	Glioblastoma	p113_case08	p.T1947P	Private mutation
SPEN	Glioblastoma	p113_case14	p.T1947P	Private mutation
SPEN	Glioblastoma	p113_case20	p.R806Tfs*14	Private mutation
SPEN	Glioma	p168_P18	p.G888E	Private mutation
SPEN	Glioma	p168_P18	p.A3534T	Private mutation
SPEN	Glioma	p168_P18	p.A3557T	Private mutation
SPEN	Head and Neck Squamous Cell Carcinoma	p074_p1	-	Private mutation
SPEN	Head and Neck Squamous Cell Carcinoma	p074_p3	-	Private mutation
SPEN	Hepatocellular Carcinoma	p151_HCC5647	Chr1:16260197:G>T	Branch mutation
SPEN	Lung Adenocarcinoma	p017_317ss	Chr1:16254989:G>C	Trunk mutation
SPEN	Lung Adenocarcinoma	p017_317ss	Chr1:16259408:G>C	Trunk mutation
SPEN	Lung Cancer	p154_p1	p.D2528E	Private mutation
SPEN	Medulloblastoma	p072_MB6	Chr1:16199447:C>A	Private mutation
SPEN	Melanoma	p043_C	p.R505C	Trunk mutation
SPEN	Melanoma	p043_H	p.R3196K	Private mutation
SPEN	Melanoma	p135_p10	Chr1:16257643:C>T	Trunk mutation
SPEN	Melanoma	p135_p10	Chr1:16261102:C>T	Trunk mutation
SPEN	Melanoma	p135_p11	Chr1:16260079:C>T	Trunk mutation
SPEN	Ovarian Cancer	p144_AOCS095	p.G1725D	Private mutation
SPEN	Ovarian Cancer	p144_AOCS150	p.V2814G	Private mutation
SPEN	Prostate Cancer	p105_1024	p.R3121W	Branch mutation
SPEN	Prostate Cancer	p116_PS352	c.9724_9724delinsGC	Private mutation
SPEN	Prostate Cancer	p164_P1	p.L1091P	Private mutation
SPEN	Prostate Cancer	p164_P1	p.A970V	Private mutation
SPEN	Renal Cancer	p085_rcc-vtt-2	-	Branch mutation
SPEN	Renal Cell Carcinoma	p073_RCC3	Chr1:16203332:C>A	Branch mutation
SPEN	Renal Cell Carcinoma	p073_RCC6	Chr1:16245573:G>A	Branch mutation
SPEN	Salivary Adenoid Cystic Carcinoma	p077_p3	p.R1403X	Trunk mutation
SPEN	Salivary Adenoid Cystic Carcinoma	p077_p5	p.D1221fs	Branch mutation
SPEN	Urothelial Carcinoma	p031_WCM077	p.T2889T	Branch mutation
SPEN	Urothelial Carcinoma	p031_WCM088	p.T2889T	Private mutation
SPEN	Urothelial Carcinoma	p031_WCM117	p.A1070S	Private mutation
SPEN	Urothelial Carcinoma	p031_WCM249	p.T2889T	Private mutation

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