PaperID	Article	Sequencing	PMID	URL	Data_source	Journal	PublishedDate
p001	A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer	Whole exome sequencing	30038269	https://www.ncbi.nlm.nih.gov/pubmed/30038269/	Fig.2,Supplementary Fig.6,Supplementary Data 3	Nat Commun	2018 Jul 23
p002	Multiregional sequencing reveals genomic alterations and clonal dynamics in primary malignant melanoma of the esophagus	Exome capture	28972077	https://www.ncbi.nlm.nih.gov/pubmed/28972077/	Fig.1 and Fig.5	Cancer Res	2018 Jan 15
p003	Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma	Whole exome sequencing	28978556	https://www.ncbi.nlm.nih.gov/pubmed/28978556/	Fig.1 and Fig.2	Cancer Discov	2018 Jan
p004	Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis	Whole exome sequencing	28911083	https://www.ncbi.nlm.nih.gov/pubmed/28911083/	Fig.2 and Fig.3,Supplementary Table S5	Annals of Oncology	2017 Sep 1
p005	Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer	Hybrid capture sequencing,Ultra-deep amplicon sequencing	28145097	https://www.ncbi.nlm.nih.gov/pubmed/28145097/	Fig.2,Fig.3,Fig.4,Fig.5,Table S6	Mol Oncol	2017 Feb
p006	Intra-individual genomic heterogeneity of high-grade serous carcinoma of ovary and clinical utility of ascitic cancer cells for mutation profiling	Whole exome sequencing	27741368	https://www.ncbi.nlm.nih.gov/pubmed/27741368/	Table S5-S8	J Pathol	2017 Jan
p007	Multiregion sequencing reveals the intratumor heterogeneity of driver mutations in TP53-driven non-small cell lung cancer	Whole exome/genome sequencing	27646734	https://www.ncbi.nlm.nih.gov/pubmed/27646734/	Supplementary Table7	Int J Cancer	2017 Jan 1
p008	Spatial intratumor heterogeneity of genetic, epigenetic alterations and temporal clonal evolution in esophageal squamous cell carcinoma	Whole exome sequencing	27749841	https://www.ncbi.nlm.nih.gov/pubmed/27749841/	Supplementary Figure 1,Supplementary Table 2	Nat Genet	2016 Dec
p009	Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition	Whole exome sequencing	27791010	https://www.ncbi.nlm.nih.gov/pubmed/27791010/	Fig. 3 and Figure S11	Proc Natl Acad Sci U S A	2016 Oct 25
p010	Multiregion Whole-Exome Sequencing Uncovers the Genetic Evolution and Mutational Heterogeneity of Early-Stage Metastatic Melanoma	Whole exome sequencing	27216186	https://www.ncbi.nlm.nih.gov/pubmed/27216186/	Figure1	Cancer Res	2016 Aug 15
p011	The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas	Whole exome sequencing	27175599	https://www.ncbi.nlm.nih.gov/pubmed/27175599/	Figure2,TableS1-S15	Oncotarget	2016 Jun 28
p012	Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer	Whole exome sequencing	26823523	https://www.ncbi.nlm.nih.gov/pubmed/26823523/	Figure1 and Supp_table2	Ann Oncol	2016 May
p013	A river model to map convergent cancer evolution and guide therapy in RCC	Targeted exome sequencing	26526752	https://www.ncbi.nlm.nih.gov/pubmed/26526752/	Figure1	Nat Rev Urol	2015 Dec
p014	Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity	Whole exome sequencing	25979483	https://www.ncbi.nlm.nih.gov/pubmed/25979483/	Figure1,Table S2	Clin Cancer Res	2015 Oct 1
p015	Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy	Whole exome sequencing	26003801	https://www.ncbi.nlm.nih.gov/pubmed/26003801/	Supplementary_Table_S3,Figure1	Cancer Discov	2015 Aug
p016	Subclonal diversification of primary breast cancer revealed by multiregion sequencing	Whole genome and targeted sequencing	26099045	https://www.ncbi.nlm.nih.gov/pubmed/26099045/	Figure4,supplement-8	Nat Med	2015 Jul
p017	Intra-tumor Heterogeneity in Localized Lung Adenocarcinomas Delineated by Multi-region Sequencing	Whole exome sequencing	25301631	https://www.ncbi.nlm.nih.gov/pubmed/25301631/	Fig. 1,SupplementaryTable2	Science	2014 Oct 10
p018	Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing	Exome sequencing	22397650	https://www.ncbi.nlm.nih.gov/pubmed/22397650/	Supplementary Table 2,Supplementary Table 4	N Engl J Med	2012 Mar 8
p019	Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing	Exome sequencing and ultra-deep sequencing	24487277	https://www.ncbi.nlm.nih.gov/pubmed/24487277/	Figure1,Supplementary Table 3	Nat Genet	2014 Mar
p020	Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma	Exome sequencing	24336570	https://www.ncbi.nlm.nih.gov/pubmed/24336570/	Supplementary Table 5,Fig. 2	Science	2014 Jan 10
p021	Spatial and temporal diversity in genomic instability processes defines lung cancer evolution	Whole exome/genome sequencing	25301630	https://www.ncbi.nlm.nih.gov/pubmed/25301630/	Supplementary Fig.s1	Science	2014 Oct 10
p022	Mutational landscape and clonal architecture in grade II and III gliomas	Whole-exome and targeted deep sequencing	25848751	https://www.ncbi.nlm.nih.gov/pubmed/25848751/	Figure 7	Nat Genet	2015 May
p023	Substantial inter-individual and limited intra-individual genomic diversity among tumors from men with metastatic prostate cancer 。。	Whole exome sequencing	26928463	https://www.ncbi.nlm.nih.gov/pubmed/26928463/	Figure 3 and SuppleSupplementary Figure 3 ,4	Nat Med	2016 Apr
p024	Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution	Whole exome/genome sequencing	25790038	https://www.ncbi.nlm.nih.gov/pubmed/25790038/	Figure3	Nat Commun	2015 Mar 19
p025	Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma	Exome sequencing	26864202	https://www.ncbi.nlm.nih.gov/pubmed/26864202/	Fig. S3	Proc Natl Acad Sci U S A	2016 Feb 23
p026	Spatial and temporal clonal evolution during development of metastatic urothelial carcinoma	Whole exome sequencing	27582092	https://www.ncbi.nlm.nih.gov/pubmed/27582092/	Figure 2	Mol Oncol	2016 Nov
p027	Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas	Panel sequencing	28201779	https://www.ncbi.nlm.nih.gov/pubmed/28201779/	Fig.4	Neuro Oncol	2017 Apr 1
p028	Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer	Whole exome sequencing	29018192	https://www.ncbi.nlm.nih.gov/pubmed/29018192/	Fig. 2,Supplementary Data 1	Nat Commun	2017 Oct 10
p029	Exome analysis of the evolutionary path of hepatocellular adenoma-carcinoma transition, vascular invasion and brain dissemination	Whole exome sequencing	28323122	https://www.ncbi.nlm.nih.gov/pubmed/28323122/	Figure 2	J Hepatol	2017 Jul
p030	Minimal functional driver gene heterogeneity among untreated metastases？	Whole exome/genome sequencing	30190408	https://www.ncbi.nlm.nih.gov/pubmed/30190408/	Figure S13~S32	Science	2018 Sep 7
p031	Clonal Evolution of Chemotherapy-resistant Urothelial Carcinoma	Whole exome sequencing	27749842	https://www.ncbi.nlm.nih.gov/pubmed/27749842/	Figure3,Figure4,TableFig 4d,Supplementary Table 10	Nat Genet	2016 Dec
p032	The Evolutionary History of Lethal Metastatic Prostate Cancer	Whole exome sequencing	25830880	https://www.ncbi.nlm.nih.gov/pubmed/25830880/	Figure 2	Urol Oncol	2016 Nov
p033	Many Private Mutations Originate From The First Few Divisions Of A Human Colorectal Adenoma	Exome sequencing	26119426	https://www.ncbi.nlm.nih.gov/pubmed/26119426/	Figure3	J Pathol	2015 Nov
p034	Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma	Exome sequencing	26336987	https://www.ncbi.nlm.nih.gov/pubmed/26336987/	Figure 4,Figure 5	Oncotarget	2015 Sep 29
p035	Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution	Whole exome sequencing	26561581	https://www.ncbi.nlm.nih.gov/pubmed/26561581/	Fig. 1	Proc Natl Acad Sci U S A	2015 Nov 24
p036	Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer	Whole exome sequencing	28092682	https://www.ncbi.nlm.nih.gov/pubmed/28092682/	Figure 2	Nat Genet	2017 Mar
p037	The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE"	Whole exome sequencing	28027312	https://www.ncbi.nlm.nih.gov/pubmed/28027312/	Figure 2,3,4,5	PLoS Med	2016 Dec 27
p038	A Big Bang model of human colorectal tumor growth	Targeted sequencing and WES	25665006	https://www.ncbi.nlm.nih.gov/pubmed/25665006/	Figure 3,Supplementary Table 1	Nat Genet	2015 Mar
p039	Paired Exome Analysis of Barrett's Esophagus and Adenocarcinoma	Whole exome sequencing	26192918	https://www.ncbi.nlm.nih.gov/pubmed/26192918/	Figure 4,5	Nat Genet	2015 Sep
p040	Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution	Exome sequencing	26890883	https://www.ncbi.nlm.nih.gov/pubmed/26890883/	Fig. 2,S3 Table	PLoS Genet	2016 Feb 18
p041	Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics	454 sequencing	23412337	https://www.ncbi.nlm.nih.gov/pubmed/23412337/	Fig. 2	Proc Natl Acad Sci U S A	2013 Mar 5
p042	The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis	Whole exome sequencing	27348297	https://www.ncbi.nlm.nih.gov/pubmed/27348297/	Supplementary Figure 13,Figure 4	Nat Genet	2016 Aug
p043	Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination	Whole exome sequencing	26286987	https://www.ncbi.nlm.nih.gov/pubmed/26286987/	Supplementary File	Proc Natl Acad Sci U S A	2015 Sep 1
p045	Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions？	Targeted sequencing and WGS	25164765	https://www.ncbi.nlm.nih.gov/pubmed/25164765/	Figure 1	Genome Biol	2014 Aug 28
p052	Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling	Exome sequencing	23780408	https://www.ncbi.nlm.nih.gov/pubmed/23780408/	Figure 1,Table S2	J Pathol	2013 Sep
p054	Distant Metastasis Occurs Late during the Genetic Evolution of Pancreatic Cancer	Whole exome sequencing	20981102	https://www.ncbi.nlm.nih.gov/pubmed/20981102/	Supplementary Figs 3‐8	Nature	2010 Oct 28
p055	Convergent loss of PTEN leads to clinical resistance to a PI3Kα inhibitor	Whole genome sequencing	25409150	https://www.ncbi.nlm.nih.gov/pubmed/25409150/	Figure 3	Nature	2015 Feb 12
p056	Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution	Whole exome/genome sequencing	25650244	https://www.ncbi.nlm.nih.gov/pubmed/25650244/	Figure 6	Genome Res	2015 Mar
p057	Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma	Exome sequencing	26554728	https://www.ncbi.nlm.nih.gov/pubmed/26554728/	Figure 1	Nat Commun	2015 Nov 10
p061	Variable Extent of Intra-tumor Heterogeneity Revealed by Genomic Sequencing of Multiple Lesions in Patients with Hepatocellular	Whole genome sequencing	26752112	https://www.ncbi.nlm.nih.gov/pubmed/26752112/	Supplementary Table 7	Gastroenterology	2016 Apr
p062	Tumor Evolution and Intratumor Heterogeneity of an Oropharyngeal Squamous Cell Carcinoma Revealed by Whole-Genome Sequencing	Whole genome sequencing	24403859	https://www.ncbi.nlm.nih.gov/pubmed/24403859/	Supplemental Table 1	Neoplasia	2013 Dec
p063	Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns	Whole genome sequencing	22915640	https://www.ncbi.nlm.nih.gov/pubmed/22915640/	Supplemental Table 6,7,8	Blood	2012 Nov 15
p065	Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient	Whole exome sequencing	28841418	https://www.ncbi.nlm.nih.gov/pubmed/28841418/	addition excel mmc1	Cell	2017 Aug 24
p066	Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing	Whole exome sequencing	25881093	https://www.ncbi.nlm.nih.gov/pubmed/25881093/	Table 1	BMC Cancer	2015 Feb 26
p068	Validation and utilisation of high-coverage next-generation sequencing to deliver the pharmacological audit trail	Targeted sequencing	24983367	https://www.ncbi.nlm.nih.gov/pubmed/24983367/	Table 2	Br J Cancer	2014 Aug 26
p069	High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer？	Whole exome/genome sequencing	25808843	https://www.ncbi.nlm.nih.gov/pubmed/25808843/	Supplementary Table 3	Genome Biol	2015 Feb 12
p070	Spatial heterogeneity in medulloblastoma	Whole exome sequencing	28394352	https://www.ncbi.nlm.nih.gov/pubmed/28394352/	Supplement-2	Nat Genet	2017 May
p071	Multiple region whole-exome sequencing reveals dramatically evolving intratumor genomic heterogeneity in esophageal squamous cell carcinoma	Whole exome sequencing	26619400	https://www.ncbi.nlm.nih.gov/pubmed/26619400/	Supplementary Table S2,S3,Figure 3	Oncogenesis	2015 Nov 30
p074	The degree of intratumor mutational heterogeneity varies by primary tumor sub-site	Target-capture deep-sequencing	27034009	https://www.ncbi.nlm.nih.gov/pubmed/27034009/	Figure 4	Oncotarget	2016 May 10
p075	Colorectal Cancer Genetic Heterogeneity Delineated by Multi-Region Sequencing	Whole exome sequencing	27023146	https://www.ncbi.nlm.nih.gov/pubmed/27023146/	Fig.1,S2 Table	PLoS One	2016 Mar 29
p076	Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer	Whole exome sequencing	29259186	https://www.ncbi.nlm.nih.gov/pubmed/29259186/	Supplementary Figure 13	Nat Commun	2017 Dec 19
p077	Spatio-Temporal Genomic Heterogeneity,Phylogeny, and Metastatic Evolution in Salivary Adenoid Cystic Carcinoma	Whole genome sequencing	29117356	https://www.ncbi.nlm.nih.gov/pubmed/29117356/	Supplementary Table 3,Figure 3	J Natl Cancer Inst	2017 Oct 1
p078	Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma	Whole exome sequencing	29497050	https://www.ncbi.nlm.nih.gov/pubmed/29497050/	Supplementary Data 2,Fig. 5	Nat Commun	2018 Mar 1
p079	Resolving the phylogenetic origin of glioblastoma via multifocal genomic analysis of pre-treatment and treatmentresistant autopsy specimens	Whole exome sequencing	29872714	https://www.ncbi.nlm.nih.gov/pubmed/29872714/	Fig. 2,Supplementary Figure 1	NPJ Precis Oncol	2017 Sep 18
p080	Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma	Whole exome sequencing	29551704	https://www.ncbi.nlm.nih.gov/pubmed/29551704/	Fig. 2,Supplementary Table 3,4	J Hepatol	2018 Jul
p081	Early evolutionary divergence between papillary and anaplastic thyroid cancers	Exome sequencing	29648575	https://www.ncbi.nlm.nih.gov/pubmed/29648575/	Figure 1	Ann Oncol	2018 Jun 1
p082	Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer	Whole exome sequencing	29169336	https://www.ncbi.nlm.nih.gov/pubmed/29169336/	Table S5,Fig.1	BMC Cancer	2017 Nov 23
p083	Identification of trunk mutations in gastric carcinoma: a case study	Whole exome sequencing	28716121	https://www.ncbi.nlm.nih.gov/pubmed/28716121/	Fig.1,Fig. S2	BMC Med Genomics	2017 Jul 17
p084	Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer	Whole exome sequencing	28916750	https://www.ncbi.nlm.nih.gov/pubmed/28916750/	Supplementary Figure S1	Sci Rep	2017 Sep 15
p085	Genomic features of renal cell carcinoma with venous tumor thrombus	Whole exome sequencing	29748622	https://www.ncbi.nlm.nih.gov/pubmed/29748622/	Figure 3	Sci Rep	2018 May 10
p087	Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma	Whole exome sequencing	27048880	https://www.ncbi.nlm.nih.gov/pubmed/27048880/	Figure 1,Supplementary Table 4	Nat Commun	2016 Apr 6
p088	Tracking the Evolution of Non-Small-Cell Lung Cancer	Whole exome sequencing	28445112	https://www.ncbi.nlm.nih.gov/pubmed/28445112/	Table S3	N Engl J Med	2017 Jun 1
p090	Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes	Targeted capture and sequencing	25608559	https://www.ncbi.nlm.nih.gov/pubmed/25608559/	Figure 2,Supp Table 3	Genome Biol	2014 Dec 3
p091	Tumor Evolution in Two Patients with Basallike Breast Cancer: A Retrospective Genomics Study of Multiple Metastases	Whole genome sequencing	27923045	https://www.ncbi.nlm.nih.gov/pubmed/27923045/	Supplementary Table 4,7	PLoS Med	2016 Dec 6
p092	Intratumor heterogeneity and clonal evolution in an aggressive papillary thyroid cancer and matched metastases	RNA-Seq,Sanger sequencing	25691441	https://www.ncbi.nlm.nih.gov/pubmed/25691441/	Supplementary_table_2	Endocr Relat Cancer	2015 Apr
p095	Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer	Targeted ultradeep sequencing	25786087	https://www.ncbi.nlm.nih.gov/pubmed/25786087/	FIGURE 3	Am J Surg Pathol	2015 Aug
p097	Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing	Whole-exome sequencing,targeted sequencing	28814763	https://www.ncbi.nlm.nih.gov/pubmed/28814763/	Fig. 2	Nat Commun	2017 Aug 16
p098	Clonally related uterine leiomyomas are common and display branched tumor evolution	Whole genome sequencing	25964426	https://www.ncbi.nlm.nih.gov/pubmed/25964426/	Table S4	Hum Mol Genet	2015 Aug 1
p100	Mutation patterns in small cell and non-small cell lung cancer patients suggest a different level of heterogeneity between primary and metastatic tumors	Whole exome sequencing	27993895	https://www.ncbi.nlm.nih.gov/pubmed/27993895/	supplementary_table_5	Carcinogenesis	2017 Feb 1
p101	Multiregion human bladder cancer sequencing reveals tumour evolution, bladder cancer phenotypes and implications for targeted therapy	Whole exome sequencing	30719704	https://www.ncbi.nlm.nih.gov/pubmed/30719704/	Figure1,Figure2	J Pathol	2019 Feb 4
p102	Multiregion Sequencing Reveals the Genetic Heterogeneity and Evolutionary History of Osteosarcoma and Matched Pulmonary Metastases	WES and WGS	30389703	https://www.ncbi.nlm.nih.gov/pubmed/30389703/	Figure2,Supplementary Fig. S1	Cancer Res	2019 Jan 1
p103	The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer	WES,WGS,targeted deep sequencing	29891724	https://www.ncbi.nlm.nih.gov/pubmed/29891724/	Figure2,Figure3,Table S4	Clin Cancer Res	2018 Oct 1
p104	Evolutionary history of human colitis-associated colorectal cancer	Exome sequencing	29991641	https://www.ncbi.nlm.nih.gov/pubmed/29991641/	Figure2,Figure4,supplementary-material-5	Gut	2018 Jul 10
p105	Genomic Heterogeneity Within Individual Prostate Cancer FociImpacts Predictive Biomarkers of Targeted Therapy	Exome sequencing	29398457	https://www.ncbi.nlm.nih.gov/pubmed/29398457/	Supplemental Table 2	Eur Urol Focus	2018 Feb 1
p106	Mutation heterogeneity between primary gastric cancers and their matched lymph node metastases	Whole-exome sequencing	30132154	https://www.ncbi.nlm.nih.gov/pubmed/30132154/	Fig.4,Table S2	Gastric Cancer	2019 Mar
p107	Local Mutational Diversity Drives Intratumoral Immune Heterogeneity in Non-Small Cell Lung Cancer	Whole-exome sequencing	30560866	https://www.ncbi.nlm.nih.gov/pubmed/30560866/	Supplementary Fig. 9,Supplementary Table 4	Nat Commun	2018 Dec
p108	Evolution of Metastases in Space and Time Under Immune Selection	Whole-exome sequencing	30318143	https://www.ncbi.nlm.nih.gov/pubmed/30318143/	Figure 2	Cell	2018 Oct 18
p109	Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA	Targeted sequencing	26374070	https://www.ncbi.nlm.nih.gov/pubmed/26374070/	Figure 3	Nat Commun	2015 Sep 16
p110	Clonal Evolution of Glioblastoma under Therapy	Whole-exome sequencing	27270107	https://www.ncbi.nlm.nih.gov/pubmed/27270107/	Figure 1	Nat Genet	2016 Jul
p111	Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations	Whole-exome sequencing,Deep sequencing	28429735	https://www.ncbi.nlm.nih.gov/pubmed/28429735/	Figure 5,Supplementary Data 3	Nat Commun	2017 Apr 20
p112	The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment	Whole-exome sequencing,Deep sequencing	30651371	https://www.ncbi.nlm.nih.gov/pubmed/30651371/	Figure 1,Supplementary Table2-5	Mol Cancer Res	2019 Apr
p113	Spatiotemporal Evolution of the Primary Glioblastoma Genome	Whole-exome sequencing	26373279	https://www.ncbi.nlm.nih.gov/pubmed/26373279/	Table S2	Cancer Cell	2015 Sep 14
p114	Clonal evolution in relapsed acute myeloid leukemia revealed by whole genome sequencing	Whole genome sequencing	22237025	https://www.ncbi.nlm.nih.gov/pubmed/22237025/	Supplementary Table 4b	Nature	2012 Jan
p115	Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma	Whole genome and transcriptome sequencing	26330360	https://www.ncbi.nlm.nih.gov/pubmed/26330360/	Supplementary table 2	Sci Rep	2015 Sep 2
p116	Regional biases in mutation screening due to intratumoural heterogeneity of prostate cancer	Whole-exome sequencing	24870262	https://www.ncbi.nlm.nih.gov/pubmed/24870262/	Table S1	J Pathol	2014 Aug
p117	Low-grade prostate cancer diverges early from high grade and metastatic disease	Exome sequencing	24890684	https://www.ncbi.nlm.nih.gov/pubmed/24890684/	Table S2	Cancer Sci	2014 Aug
p118	Spatial genomic heterogeneity within localized, multifocal prostate cancer	Whole genome sequencing	26005866	https://www.ncbi.nlm.nih.gov/pubmed/26005866/	SupplementaryTable13	Nat Genet	2015 Jul
p119	Intratumoral and Intertumoral Genomic Heterogeneity of Multifocal Localized Prostate Cancer Impacts Molecular Classifications and Genomic Prognosticators	Whole exome sequencing	27451135	https://www.ncbi.nlm.nih.gov/pubmed/27451135/	SupplementaryTable3	Eur Urol	2017 Feb
p120	Early and multiple origins of metastatic lineages within primary tumors	Whole exome sequencing	26858460	https://www.ncbi.nlm.nih.gov/pubmed/26858460/	Fig.1	Proc Natl Acad Sci U S A	2016 Feb 23
p121	Genomic characterization of brain metastases reveals branched  evolution and potential therapeutic targets	Whole exome sequencing	26410082	https://www.ncbi.nlm.nih.gov/pubmed/26410082/	Fig.1,Fig.3,Fig.4	Cancer Discov	2015 Nov
p122	Genomic Evolution of Breast Cancer Metastasis and Relapse	Whole genome sequencing	28810143	https://www.ncbi.nlm.nih.gov/pubmed/28810143/	Table S3	Cancer Cell	2017 Aug 14
p123	Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases	Whole-exome sequencing	28351929	https://www.ncbi.nlm.nih.gov/pubmed/28351929/	Supplementary Table S3	Clin Cancer Res	2017 Aug 1
p124	Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma  20190411	Whole-exome sequencing	30975989	https://www.ncbi.nlm.nih.gov/pubmed/30975989/	Supplementary Data 2a	Nat Commun	2019 Apr 11
p125	Mutation landscape and intra-tumor heterogeneity of two MANECs of the esophagus revealed by multi-region sequencing	Whole-exome sequencing,whole-genome SNP genotyping	29050228	https://www.ncbi.nlm.nih.gov/pubmed/29050228/	Table S3A,Table S3B	Oncotarget	2017 Jun 27
p126	Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer？	Whole-genome sequencing	30348992	https://www.ncbi.nlm.nih.gov/pubmed/30348992/	Supplementary Data File S3	Oncogene	2019 Mar
p127	Cousins not twins: intratumoural and intertumoural heterogeneity in syndromic neuroendocrine tumours	Whole-exome sequencing	28369925	https://www.ncbi.nlm.nih.gov/pubmed/28369925/	Supplementary Table 1	J Pathol	2017 Jul
p128	Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing	Whole-exome sequencing	28900112	https://www.ncbi.nlm.nih.gov/pubmed/28900112/	Supplementary Data 4	Nat Commun	2017 Sep 12
p129	Genomic heterogeneity and exceptional response to dual pathway inhibition in anaplastic thyroid cancer	Whole-exome sequencing	27797976	https://www.ncbi.nlm.nih.gov/pubmed/27797976/	Supplementary Figure 1	Clin Cancer Res	2017 May 1
p130	The evolutionary landscape of colorectal tumorigenesis	Whole-genome sequencing	30177804	https://www.ncbi.nlm.nih.gov/pubmed/30177804/	Figure 2	Nat Ecol Evol	2018 Oct
p131	Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity	Whole-exome sequencing	30404001	https://www.ncbi.nlm.nih.gov/pubmed/30404001/	Table S4	Cell Rep	2018 Nov 6
p132	Intratumor Heterogeneity of Homologous Recombination Deficiency in Primary Breast Cancer	Deep sequencing	27601588	https://www.ncbi.nlm.nih.gov/pubmed/27601588/	Figure 2	Clin Cancer Res	2017 Mar 1
p133	Spatio-temporal mutation profiles of casematched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing	Targeted sequencing	27756406	https://www.ncbi.nlm.nih.gov/pubmed/27756406/	SuppTableS4	Mol Cancer	2016 Oct 18
p134	Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multiregion exome sequencing	Whole-exome sequencing,Deep sequencing	29335443	https://www.ncbi.nlm.nih.gov/pubmed/29335443/	Supplementary Table 3	Nat Commun	2018 Jan 15
p135	Molecular and genetic diversity in the metastatic process of melanoma	Targeted-capture deep sequencing	24399611	https://www.ncbi.nlm.nih.gov/pubmed/24399611/	TableS4-TableS25	Nat Commun	2018 Jan 15
p136	Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer	Whole-genome and ultra-deep targeted sequencing	25827447	https://www.ncbi.nlm.nih.gov/pubmed/25827447/	Figure2	Nat Commun	2015 Apr 1
p137	Comparative genomic analysis of primary tumors and metastases in breast cancer	Whole exome, whole genome sequencing	27028851	https://www.ncbi.nlm.nih.gov/pubmed/27028851/	Supplementary Table S2	Oncotarget	2016 May 10
p138	The correlations of tumor mutational burden among single-region tissue, multiregion tissues and blood in non-small cell lung cancer	Whole exome sequencing	30944026	https://www.ncbi.nlm.nih.gov/pubmed/30944026/	Figure S3	J Immunother Cancer	2019 Apr 3
p139	Genetic Alterations in Esophageal Tissues From Squamous Dysplasia to Carcinoma 	WES/WGS,Targeted Sequencing	28365443	https://www.ncbi.nlm.nih.gov/pubmed/28365443/	Supplementary Table 12	Gastroenterology	2017 Jul
p140	Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue	Genome-wide sequencing	25730763	https://www.ncbi.nlm.nih.gov/pubmed/25730763/	Supplementary Table 3	Nat Genet	2015 Apr
p141	Genomic landscape of liposarcoma	Whole exome sequencing	26643872	https://www.ncbi.nlm.nih.gov/pubmed/26643872/	Figure6	Oncotarget	2015 Dec 15
p142	Paired Exome Analysis Reveals Clonal Evolution and Potential Therapeutic Targets in Urothelial Carcinoma	Whole exome sequencing	27488526	https://www.ncbi.nlm.nih.gov/pubmed/27488526/	Figure S13,Figure S10	Cancer Res	2016 Oct 1
p143	Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy	Whole exome sequencing	30737380	https://www.ncbi.nlm.nih.gov/pubmed/30737380/	Supplementary Data 2	Nat Commun	2019 Feb 8
p144	Whole-genome characterization of chemoresistant ovarian cancer	Whole genome sequencing	26503049	https://www.ncbi.nlm.nih.gov/pubmed/26503049/	Supplementary Table 9	Nature	2015 Nov 19
p145	Mutational profiling of brain metastasis from breast cancer: matched pair analysis of targeted sequencing between brain metastasis and primary breast cancer	Targeted sequencing	26527317	https://www.ncbi.nlm.nih.gov/pubmed/26527317/	Table 3	Oncotarget	2015 Dec 22
p146	Patterns of somatic alterations betweenmatched primary and metastatic colorectal tumors characterized by whole-genome sequencing	Whole genome sequencing	25066378	https://www.ncbi.nlm.nih.gov/pubmed/26527317/	Table S1	Genomics	2014 Oct
p147	Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels	Exome sequencing,RNA sequencing	26109429	https://www.ncbi.nlm.nih.gov/pubmed/26109429/	Table S4	Oncotarget	2015 Sep 8
p148	Next-Generation Sequencing Reveals High Concordance of Recurrent Somatic Alterations Between Primary Tumor and Metastases From Patients With Non–Small-Cell Lung Cancer	Targeted sequencing	23630207	https://www.ncbi.nlm.nih.gov/pubmed/23630207/	Table A1	J Clin Oncol	2013 Jun 10
p149	Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases	Targeted and amplicon sequencing	29755676	https://www.ncbi.nlm.nih.gov/pubmed/29755676/	Supplementary Table 4	Oncotarget	2018 Apr 17
p150	Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle	Targeted capture sequencing	25009010	https://www.ncbi.nlm.nih.gov/pubmed/25009010/	Table 1	Ann Oncol	2014 Sep
p151	Genomic and epigenomic heterogeneity of hepatocellular carcinoma	Whole-exome sequencing	28302680	https://www.ncbi.nlm.nih.gov/pubmed/28302680/	Supplementary Table 5	Cancer Res	2017 May 1
p152	DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer 	Targeted sequencing	28120820	https://www.ncbi.nlm.nih.gov/pubmed/28120820/	Supplementary Data 1	Nat Commun	2017 Jan 25
p153	Clonality, Heterogeneity, and Evolution of Synchronous Bilateral Ovarian Cancer	Whole-exome sequencing	28972072	https://www.ncbi.nlm.nih.gov/pubmed/28972072/	Supplementary Table S3	Cancer Res	2017 Dec 1
p154	Genomic heterogeneity of multiple synchronous lung cancer	WES/WGS	27767028	https://www.ncbi.nlm.nih.gov/pubmed/27767028/	Supplementary Table 4	Nat Commun	2016 Oct 21
p155	Whole exome sequencing reveals intertumor heterogeneity and distinct genetic origins of sporadic synchronous colorectal cancer	Whole-exome sequencing	29105743	https://www.ncbi.nlm.nih.gov/pubmed/29105743/	Supplementary Table 3	Int J Cancer	2018 Mar 1
p157	Multi-omics study revealing the complexity and spatial heterogeneity of tumor-infiltrating lymphocytes in primary liver carcinoma	Whole-exome sequencing	28422742	https://www.ncbi.nlm.nih.gov/pubmed/28422742/	Supplementary Table S5	Oncotarget	2017 May 23
p158	Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity tumor he in melanoma	Whole-exome sequencing	26672766	https://www.ncbi.nlm.nih.gov/pubmed/26672766/	Supplementary Table 3	Oncotarget	2016 Jan 19
p159	Intratumoral heterogeneity of intrahepatic cholangiocarcinoma	Whole-exome sequencing	28146430	https://www.ncbi.nlm.nih.gov/pubmed/28146430/	Supplementary Table S2	Oncotarget	2017 Feb 28
p160	Innate Genetic Evolution of Lung Cancers and Spatial Heterogeneity: Analysis of Treatment-Naïve Lesions	RNA-sequencing	29933065	https://www.ncbi.nlm.nih.gov/pubmed/29933065/	Figure 2-3,Supplementary Figure 1-3	J Thorac Oncol	2018 Oct
p161	Inter- and intra-tumor profiling of multi-regional colon cancer and metastasis	Targeted re-sequencing	25623536	https://www.ncbi.nlm.nih.gov/pubmed/25623536/	Table2,Table3	Biochem Biophys Res Commun	2015 Feb 27
p162	Characterizing Mutational Heterogeneity in a Glioblastoma Patient with Double Recurrence Gabrielle	Ultra-deep sequencing	22536362	https://www.ncbi.nlm.nih.gov/pubmed/22536362/	Table S2	PLoS One	2012
p163	Intratumor heterogeneity comparison among different subtypes of non-small-cell lung cancer through multi-region tissue and matched ctDNA sequencing	Targeted capture sequencing	30626401	https://www.ncbi.nlm.nih.gov/pubmed/30626401/	Additional file 10	Mol Cancer	2019 Jan 9
p164	Spatial Intratumor Genomic Heterogeneity within Localized Prostate Cancer Revealed by Single-nucleus Sequencing	Single-cell whole genome sequencing	29941308	https://www.ncbi.nlm.nih.gov/pubmed/29941308/	Table S7	Eur Urol	2018 Nov
p165	Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions	Single-cell sequencing	30430578	https://www.ncbi.nlm.nih.gov/pubmed/30430578/	Table 1,Table s1,Table s3	J Pathol	2019 Mar
p167	Tracking the clonal origin of lethal prostate cancer	Whole genome sequencing	24135135	https://www.ncbi.nlm.nih.gov/pubmed/24135135/	Table S2	J Clin Invest	2013 Nov
p168	DNA methylation and somatic mutations converge on cell cycle and define similar evolutionary histories in brain tumors	Exome sequencing	26373278	https://www.ncbi.nlm.nih.gov/pubmed/26373278/	Table S5	Cancer Cell	2015 Sep 14