| PubMed ID |
|
26084493 |
Publish Date |
|
2015 Jun |
| Journal |
|
Nat Rev Genet |
Species |
|
|
| Disease Type |
|
|
Technology |
|
|
| Title |
|
Genome stability: Chromothripsis and micronucleus formation. |
| Authors |
|
Waldron D |
| Affiliation |
|
|
| Chromothripsis Definition |
|
Close-by breakpoints: NA
Copy number states: NA
Fragments random joining: NA |
| Abstract |
|
It has generally been assumed that cancers arise through the accumulation of individual muta- tions over time; however, recent cancer genome sequence analyses suggest that multiple mutations can arise simultaneously during a single event such as chromothripsis, which results in extensive genomic rearrangements that are usually con- fined to a single chromosome. |
