TARS2

 

Full name: threonyl-tRNA synthetase 2, mitochondrial Alias Symbol: FLJ12528
Type: protein-coding gene Cytoband: 1q21.2
Entrez ID: 80222 HGNC ID: HGNC:30740 Ensembl Gene: ENSG00000143374 OMIM ID: 612805
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of TARS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 TARS2 80222 60730 0.0748 0.3599
GSE53624 TARS2 80222 60730 0.1466 0.0127
GSE97050 TARS2 80222 A_23_P553 0.1117 0.6575
SRP007169 TARS2 80222 RNAseq -0.7279 0.0647
SRP008496 TARS2 80222 RNAseq -0.6251 0.0041
SRP064894 TARS2 80222 RNAseq -0.0121 0.9393
SRP133303 TARS2 80222 RNAseq 0.0798 0.6619
SRP159526 TARS2 80222 RNAseq 0.6362 0.0950
SRP193095 TARS2 80222 RNAseq -0.0046 0.9620
SRP219564 TARS2 80222 RNAseq 0.1344 0.7433
TCGA TARS2 80222 RNAseq 0.0448 0.4216

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TARS2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TARS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TARS2 80222 15 0 15
GSE20123 TARS2 80222 15 0 15
GSE43470 TARS2 80222 6 1 36
GSE46452 TARS2 80222 2 1 56
GSE47630 TARS2 80222 14 0 26
GSE54993 TARS2 80222 0 3 67
GSE54994 TARS2 80222 15 0 38
GSE60625 TARS2 80222 0 0 11
GSE74703 TARS2 80222 6 1 29
GSE74704 TARS2 80222 7 0 13
TCGA TARS2 80222 38 2 56

Total number of gains: 118; Total number of losses: 8; Total Number of normals: 362.  

 

Somatic mutations of TARS2:

 

Generating mutation plots.

 

Highly correlated genes for TARS2:

 

Showing all 3 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TARS2SCAMP30.754191303
TARS2DALRD30.691541303
TARS2CCDC1670.592619303

For details and further investigation, click here