Browse consensus DEGs in ESCCdb

By integrating DEGs from 20 datasets, we identified 789 consensus DEGs that were consistently and significantly differential expressed in more than half of these datasets.

Showing 1-20/789

Gene Over Express Down Express CN Gain CN Loss CN Norm Synony NonSynony Cor Genes
ABAT013100453436255435
ABCA1312012521342221298479
ABCA801510427357213071560
ABCC5100276281847298747
ABHD5016172372342471632
ABLIM3018231493160210750
ACAA1013162362362171600
ACADM01531593980901753
ACOX1012120293392921707
ACOX2011142312431371544
ACOX30132419027401061847
ACPP0102082925131701883
ACTL6A1402762718501002201
ACVR1C100573040163271024
ADA130181272801581925
ADAMTS21103114830916444598
ADAMTSL401011883622065948
ADH1B01519167302221411
ADH7012191653042421141
ADIRF013199337619828
Page 1/40 First Prev Next Last Jump to page

KEGG and reactome enrichment analysis of consensus up-regulated genes

Showing top 1-10/14 KEGG enriched records.
ID Description P.adjust Count Genes Promoter scan
hsa04110Cell cycle0.000024MCM6, CDC20, CDC25B, MCM2, ORC6, MAD2L1, BUB1, TTK, CHEK1, MCM5, CDK1, CCNB2, MCM4, MCM7, BUB1B, CDC45, PCNA, CDC6, DBF4, MCM3, CDK4, CCNB1,...
hsa03030DNA replication0.000011MCM6, MCM2, MCM5, RFC4, MCM4, MCM7, FEN1, PCNA, RNASEH2A, MCM3, PRIM2
hsa04512ECM-receptor interaction0.000013LAMC2, LAMB3, ITGB4, AGRN, ITGA6, SPP1, HMMR, COL4A5, COL4A2, ITGAV, LAMA3, TNC, ITGA3
hsa05222Small cell lung cancer0.000012CKS1B, LAMC2, LAMB3, ITGA6, CKS2, COL4A5, CDK4, COL4A2, ITGAV, LAMA3, ITGA3, CDK6
hsa04115p53 signaling pathway0.000010BID, CHEK1, CDK1, CCNB2, CDK4, CCNB1, IGFBP3, SERPINE1, RRM2, CDK6
hsa05165Human papillomavirus infection0.002021LAMC2, LAMB3, ITGB4, FZD6, ITGA6, ATP6V1C1, SPP1, FZD2, HEY1, ISG15, EIF2AK2, COL4A5, CDK4, COL4A2, ITGAV, LAMA3, FADD, TNC, ITGA3, CDK6, WN...
hsa05202Transcriptional misregulation in cancer0.008014PLAU, SIX4, HOXA10, MLF1, TCF3, CXCL8, MET, MMP9, SIX1, HMGA2, IGFBP3, ETV5, RUNX2, BCL2A1
hsa04218Cellular senescence0.011012MYBL2, ITPR3, FOXM1, CHEK1, CDK1, CCNB2, CXCL8, CDK4, CCNB1, IGFBP3, SERPINE1, CDK6
hsa04114Oocyte meiosis0.029010ITPR3, CDC20, AURKA, MAD2L1, BUB1, CDK1, CCNB2, FBXO5, CCNB1, PLK1
hsa05206MicroRNAs in cancer0.032017PLAU, CDC25B, DNMT3B, CDCA5, KIF23, DNMT1, FSCN1, MET, MMP9, STMN1, HMGA2, TNC, EFNA1, TP63, HOXD10, BRCA1, CDK6
Page 1/2 First Prev Next Last Jump to page
Showing top 1-10/100 Reactome enriched records.
ID Description P.adjust Count Genes Promoter scan
R-HSA-69620Cell Cycle Checkpoints0.000042UBE2C, MCM6, AURKB, CDC20, MCM2, SPC25, CENPN, EXO1, KIF18A, ORC6, CENPE, CENPF, MAD2L1, BUB1, CENPI, BLM, MCM10, MCM8, CHEK1, CENPA, MCM5, ...
R-HSA-176974Unwinding of DNA0.000011MCM6, MCM2, MCM8, MCM5, GINS2, GINS1, MCM4, MCM7, CDC45, MCM3, GINS4
R-HSA-69190DNA strand elongation0.000015MCM6, MCM2, MCM8, MCM5, RFC4, GINS2, GINS1, MCM4, MCM7, FEN1, CDC45, PCNA, MCM3, GINS4, PRIM2
R-HSA-453279Mitotic G1-G1/S phases0.000027MYBL2, CKS1B, GMNN, MCM6, MCM2, ORC6, MCM10, MCM8, MCM5, TOP2A, CDK1, MCM4, MCM7, TK1, CDC45, PCNA, CDC6, FBXO5, DBF4, MCM3, CDK4, CCNB1, RR...
R-HSA-68962Activation of the pre-replicative complex0.000015GMNN, MCM6, MCM2, ORC6, MCM10, MCM8, MCM5, MCM4, MCM7, CDC45, CDC6, DBF4, MCM3, PRIM2, CDT1
R-HSA-2500257Resolution of Sister Chromatid Cohesion0.000024AURKB, CDC20, SPC25, CENPN, KIF18A, CENPE, CDCA5, CENPF, MAD2L1, BUB1, CENPI, CENPA, NUF2, CDCA8, KIF2C, CDK1, CCNB2, NUP107, NDC80, BUB1B, ...
R-HSA-69206G1/S Transition0.000024CKS1B, GMNN, MCM6, MCM2, ORC6, MCM10, MCM8, MCM5, CDK1, MCM4, MCM7, TK1, CDC45, PCNA, CDC6, FBXO5, DBF4, MCM3, CDK4, CCNB1, RRM2, TYMS, PRIM...
R-HSA-68877Mitotic Prometaphase0.000028AURKB, CDC20, SPC25, NEK2, CENPN, KIF18A, CENPE, CDCA5, CENPF, MAD2L1, BUB1, CENPI, CENPA, NUF2, NCAPH, CDCA8, NCAPG, KIF2C, CDK1, CCNB2, NU...
R-HSA-176187Activation of ATR in response to replication stress0.000014MCM6, MCM2, ORC6, MCM10, MCM8, CHEK1, MCM5, RFC4, MCM4, MCM7, CDC45, CDC6, DBF4, MCM3
R-HSA-141424Amplification of signal from the kinetochores0.000020AURKB, CDC20, SPC25, CENPN, KIF18A, CENPE, CENPF, MAD2L1, BUB1, CENPI, CENPA, NUF2, CDCA8, KIF2C, NUP107, NDC80, BUB1B, BIRC5, KNTC1, PLK1
Page 1/10 First Prev Next Last Jump to page
Full KEGG and Reactome enrichment results is available here

KEGG and reactome enrichment analysis of consensus down-regulated genes

Showing all 10 KEGG enriched records.
ID Description P.adjust Count Genes Promoter scan
hsa00071Fatty acid degradation0.00009ALDH3A2, ADH1B, ACOX3, ACOX1, ACAA1, ALDH9A1, ACADM, ADH7, ALDH7A1
hsa00590Arachidonic acid metabolism0.00109CBR3, GPX3, EPHX2, CYP2J2, ALOX12, CYP2C9, CYP2E1, PTGS1, ALOX15B
hsa00410beta-Alanine metabolism0.00406ALDH3A2, ACOX3, ACOX1, ALDH9A1, ABAT, ALDH7A1
hsa01040Biosynthesis of unsaturated fatty acids0.02005ACOX3, ACOX1, ACAA1, ELOVL6, ELOVL4
hsa00280Valine, leucine and isoleucine degradation0.03506ALDH3A2, ACAA1, ALDH9A1, ACADM, ABAT, ALDH7A1
hsa00830Retinol metabolism0.03507ADH1B, CYP2C18, CYP2C9, DHRS9, ADH7, CYP3A5, RDH12
hsa04726Serotonergic synapse0.03509CYP2J2, ITPR2, CYP2C18, ALOX12, CYP2C9, PTGS1, DUSP1, ALOX15B, MAPK3
hsa00982Drug metabolism - cytochrome P4500.03507MGST2, ADH1B, FMO2, CYP2C9, CYP2E1, ADH7, CYP3A5
hsa01212Fatty acid metabolism0.04106ACOX3, ACOX1, ACAA1, ELOVL6, ELOVL4, ACADM
hsa00980Metabolism of xenobiotics by cytochrome P4500.04107CBR3, MGST2, ADH1B, CYP2C9, CYP2E1, ADH7, CYP3A5
Page 1/1 First Prev Next Last Jump to page
Showing top 1-10/11 Reactome enriched records.
ID Description P.adjust Count Genes Promoter scan
R-HSA-6798695Neutrophil degranulation0.002029CRISP3, CFD, GSN, ACPP, SYNGR1, METTL7A, CXCR2, VAT1, HEBP2, TOM1, PRSS3, ACAA1, SERPINB1, CPPED1, CEACAM1, NBEAL2, CSTB, CDA, SERPINB6, ATP...
R-HSA-8978868Fatty acid metabolism0.002016CYP4B1, ACOX2, EPHX2, ALDH3A2, ACOX3, CYP2J2, ACOX1, ACAA1, HPGD, ELOVL6, ALOX12, CYP2C9, ELOVL4, ACADM, PTGS1, ALOX15B
R-HSA-211945Phase I - Functionalization of compounds0.002012CBR3, CYP4B1, ADH1B, FMO2, CYP2J2, CYP2C18, CES2, CYP2C9, CYP2E1, PTGS1, ADH7, CYP3A5
R-HSA-9018677Biosynthesis of DHA-derived SPMs0.00605EPHX2, HPGD, ALOX12, CYP2C9, CYP2E1
R-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)0.00805EPHX2, HPGD, ALOX12, CYP2C9, CYP2E1
R-HSA-2142753Arachidonic acid metabolism0.00808CYP4B1, EPHX2, CYP2J2, HPGD, ALOX12, CYP2C9, PTGS1, ALOX15B
R-HSA-211859Biological oxidations0.009016CBR3, CYP4B1, MGST2, ADH1B, FMO2, CYP2J2, SULT2B1, CYP2C18, CES2, CYP2C9, CYP2E1, PTGS1, ADH7, CYP3A5, SLC26A2, CHAC1
R-HSA-211981Xenobiotics0.01805CYP2J2, CYP2C18, CYP2C9, CYP2E1, CYP3A5
R-HSA-6809371Formation of the cornified envelope0.020011SPINK5, KRT78, EVPL, TGM1, KLK13, FLG, KLK12, IVL, KRT13, SPRR3, SPRR1A
R-HSA-390918Peroxisomal lipid metabolism0.03605ACOX2, ALDH3A2, ACOX3, ACOX1, ACAA1
Page 1/2 First Prev Next Last Jump to page
Full KEGG and Reactome enrichment results is available here