EIF4E1B

 

Full name: eukaryotic translation initiation factor 4E family member 1B Alias Symbol: FLJ36951
Type: protein-coding gene Cytoband: 5q35.2
Entrez ID: 253314 HGNC ID: HGNC:33179 Ensembl Gene: ENSG00000175766 OMIM ID: 
Drug and gene relationship at DGIdb

 

EIF4E1B involved pathways:

KEGG pathway Description View
hsa04066HIF-1 signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04910Insulin signaling pathway

 

Expression of EIF4E1B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 EIF4E1B 253314 33937 -1.7186 0.0000
GSE53624 EIF4E1B 253314 33937 -0.5651 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by EIF4E1B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EIF4E1B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EIF4E1B 253314 2 13 15
GSE20123 EIF4E1B 253314 2 13 15
GSE43470 EIF4E1B 253314 1 11 31
GSE46452 EIF4E1B 253314 0 27 32
GSE47630 EIF4E1B 253314 0 20 20
GSE54993 EIF4E1B 253314 10 2 58
GSE54994 EIF4E1B 253314 2 17 34
GSE60625 EIF4E1B 253314 1 0 10
GSE74703 EIF4E1B 253314 1 7 28
GSE74704 EIF4E1B 253314 1 6 13
TCGA EIF4E1B 253314 7 35 54

Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.  

 

Somatic mutations of EIF4E1B:

 

Generating mutation plots.

 

Highly correlated genes for EIF4E1B:

 

Showing all 2 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EIF4E1BMAGEC30.683301303
EIF4E1BOR2Z10.662623303

For details and further investigation, click here