NHEJ1

 

Full name: non-homologous end joining factor 1 Alias Symbol: Cernunnos|XLF|FLJ12610
Type: protein-coding gene Cytoband: 2q35
Entrez ID: 79840 HGNC ID: HGNC:25737 Ensembl Gene: ENSG00000187736 OMIM ID: 611290
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of NHEJ1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 NHEJ1 79840 70604 0.0055 0.9446
GSE53624 NHEJ1 79840 70604 0.1429 0.0123
GSE97050 NHEJ1 79840 A_24_P251381 0.0251 0.9107
SRP007169 NHEJ1 79840 RNAseq 0.0204 0.9760
SRP064894 NHEJ1 79840 RNAseq 0.1014 0.4584
SRP133303 NHEJ1 79840 RNAseq 0.1848 0.2683
SRP159526 NHEJ1 79840 RNAseq -0.0111 0.9658
SRP193095 NHEJ1 79840 RNAseq -0.0967 0.4972
SRP219564 NHEJ1 79840 RNAseq 0.0376 0.8949
TCGA NHEJ1 79840 RNAseq -0.0287 0.6353

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NHEJ1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NHEJ1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NHEJ1 79840 2 14 14
GSE20123 NHEJ1 79840 2 13 15
GSE43470 NHEJ1 79840 1 7 35
GSE46452 NHEJ1 79840 0 5 54
GSE47630 NHEJ1 79840 4 5 31
GSE54993 NHEJ1 79840 1 2 67
GSE54994 NHEJ1 79840 7 10 36
GSE60625 NHEJ1 79840 0 3 8
GSE74703 NHEJ1 79840 1 5 30
GSE74704 NHEJ1 79840 2 7 11
TCGA NHEJ1 79840 12 26 58

Total number of gains: 32; Total number of losses: 97; Total Number of normals: 359.  

 

Somatic mutations of NHEJ1:

 

Generating mutation plots.

 

Highly correlated genes for NHEJ1:

 

Showing all 1 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NHEJ1BCS1L0.704983303

For details and further investigation, click here