SIGLEC16

 

Full name: sialic acid binding Ig like lectin 16 (gene/pseudogene) Alias Symbol: Siglec-P16
Type: protein-coding gene Cytoband: 19q13.33
Entrez ID: 400709 HGNC ID: HGNC:24851 Ensembl Gene: ENSG00000161643 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of SIGLEC16:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SIGLEC16 400709 1561880_a_at -0.0157 0.9602
GSE26886 SIGLEC16 400709 1561880_a_at -0.0258 0.8132
GSE45670 SIGLEC16 400709 1561880_a_at 0.0271 0.7284
GSE63941 SIGLEC16 400709 1561880_a_at -0.0288 0.8631
GSE77861 SIGLEC16 400709 1561880_a_at 0.0115 0.9018
SRP007169 SIGLEC16 400709 RNAseq -0.4044 0.6097
SRP064894 SIGLEC16 400709 RNAseq 0.1400 0.6533
SRP133303 SIGLEC16 400709 RNAseq -0.3379 0.0026
SRP159526 SIGLEC16 400709 RNAseq -0.2708 0.4733
SRP193095 SIGLEC16 400709 RNAseq -0.0380 0.8027
SRP219564 SIGLEC16 400709 RNAseq 0.1444 0.7144
TCGA SIGLEC16 400709 RNAseq -1.5851 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by SIGLEC16 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of SIGLEC16:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SIGLEC16 400709 4 4 22
GSE20123 SIGLEC16 400709 4 3 23
GSE43470 SIGLEC16 400709 5 11 27
GSE46452 SIGLEC16 400709 45 1 13
GSE47630 SIGLEC16 400709 10 6 24
GSE54993 SIGLEC16 400709 17 4 49
GSE54994 SIGLEC16 400709 4 14 35
GSE60625 SIGLEC16 400709 9 0 2
GSE74703 SIGLEC16 400709 5 7 24
GSE74704 SIGLEC16 400709 4 1 15
TCGA SIGLEC16 400709 14 18 64

Total number of gains: 121; Total number of losses: 69; Total Number of normals: 298.  

 

Somatic mutations of SIGLEC16:

 

Generating mutation plots.

 

Highly correlated genes for SIGLEC16:

 

Showing all 2 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SIGLEC16OR51B20.662696303
SIGLEC16CCM2L0.555301303

For details and further investigation, click here