LRGUK

 

Full name: leucine rich repeats and guanylate kinase domain containing Alias Symbol: FLJ32786|CFAP246
Type: protein-coding gene Cytoband: 7q33
Entrez ID: 136332 HGNC ID: HGNC:21964 Ensembl Gene: ENSG00000155530 OMIM ID: 616478
Drug and gene relationship at DGIdb

 

Expression of LRGUK:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LRGUK 136332 244710_at 0.2430 0.6496
GSE26886 LRGUK 136332 244710_at 0.0172 0.9061
GSE45670 LRGUK 136332 244710_at 0.3827 0.0459
GSE53622 LRGUK 136332 123236 0.7425 0.0000
GSE53624 LRGUK 136332 123236 0.7180 0.0000
GSE63941 LRGUK 136332 244710_at -0.1240 0.4775
GSE77861 LRGUK 136332 244710_at -0.1799 0.1485
GSE97050 LRGUK 136332 A_24_P346517 -0.0254 0.9454
SRP133303 LRGUK 136332 RNAseq 0.7564 0.0390
SRP159526 LRGUK 136332 RNAseq 1.8695 0.0200
SRP219564 LRGUK 136332 RNAseq 1.1392 0.1970
TCGA LRGUK 136332 RNAseq 0.0698 0.8861

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by LRGUK expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LRGUK:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LRGUK 136332 6 2 22
GSE20123 LRGUK 136332 6 2 22
GSE43470 LRGUK 136332 2 3 38
GSE46452 LRGUK 136332 7 2 50
GSE47630 LRGUK 136332 7 4 29
GSE54993 LRGUK 136332 3 5 62
GSE54994 LRGUK 136332 6 8 39
GSE60625 LRGUK 136332 0 0 11
GSE74703 LRGUK 136332 2 3 31
GSE74704 LRGUK 136332 2 2 16
TCGA LRGUK 136332 28 26 42

Total number of gains: 69; Total number of losses: 57; Total Number of normals: 362.  

 

Somatic mutations of LRGUK:

 

Generating mutation plots.

 

Highly correlated genes for LRGUK:

 

Showing all 4 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LRGUKEPB41L50.613208303
LRGUKANKRD10.594728303
LRGUKIFNG0.587229403
LRGUKPRLR0.534901303

For details and further investigation, click here