| Full name: prolactin receptor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5p13.2 | ||
| Entrez ID: 5618 | HGNC ID: HGNC:9446 | Ensembl Gene: ENSG00000113494 | OMIM ID: 176761 |
| Drug and gene relationship at DGIdb | |||
PRLR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway | |
| hsa04917 | Prolactin signaling pathway |
Expression of PRLR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRLR | 5618 | 210476_s_at | -0.1060 | 0.7379 | |
| GSE20347 | PRLR | 5618 | 210476_s_at | 0.0203 | 0.8615 | |
| GSE23400 | PRLR | 5618 | 210476_s_at | -0.2741 | 0.0000 | |
| GSE26886 | PRLR | 5618 | 210476_s_at | -0.1186 | 0.2612 | |
| GSE29001 | PRLR | 5618 | 210476_s_at | 0.0529 | 0.8096 | |
| GSE38129 | PRLR | 5618 | 210476_s_at | -0.1428 | 0.2355 | |
| GSE45670 | PRLR | 5618 | 210476_s_at | 0.1013 | 0.1845 | |
| GSE53622 | PRLR | 5618 | 132534 | -1.0016 | 0.0009 | |
| GSE53624 | PRLR | 5618 | 20342 | -0.9528 | 0.0000 | |
| GSE63941 | PRLR | 5618 | 210476_s_at | -0.0420 | 0.8141 | |
| GSE77861 | PRLR | 5618 | 210476_s_at | -0.1088 | 0.3460 | |
| GSE97050 | PRLR | 5618 | A_23_P167468 | 0.4250 | 0.3374 | |
| SRP007169 | PRLR | 5618 | RNAseq | 1.3091 | 0.3894 | |
| SRP064894 | PRLR | 5618 | RNAseq | -0.6812 | 0.0942 | |
| SRP133303 | PRLR | 5618 | RNAseq | -0.5044 | 0.1617 | |
| SRP159526 | PRLR | 5618 | RNAseq | 1.6852 | 0.0944 | |
| SRP193095 | PRLR | 5618 | RNAseq | -1.3695 | 0.0006 | |
| SRP219564 | PRLR | 5618 | RNAseq | -0.3922 | 0.5476 | |
| TCGA | PRLR | 5618 | RNAseq | -1.1274 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PRLR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRLR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRLR | 5618 | 10 | 0 | 20 | |
| GSE20123 | PRLR | 5618 | 10 | 0 | 20 | |
| GSE43470 | PRLR | 5618 | 17 | 0 | 26 | |
| GSE46452 | PRLR | 5618 | 6 | 21 | 32 | |
| GSE47630 | PRLR | 5618 | 6 | 12 | 22 | |
| GSE54993 | PRLR | 5618 | 5 | 4 | 61 | |
| GSE54994 | PRLR | 5618 | 26 | 2 | 25 | |
| GSE60625 | PRLR | 5618 | 0 | 0 | 11 | |
| GSE74703 | PRLR | 5618 | 13 | 0 | 23 | |
| GSE74704 | PRLR | 5618 | 9 | 0 | 11 | |
| TCGA | PRLR | 5618 | 52 | 6 | 38 |
Total number of gains: 154; Total number of losses: 45; Total Number of normals: 289.
Somatic mutations of PRLR:
Generating mutation plots.
Highly correlated genes for PRLR:
Showing top 20/667 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRLR | ERCC4 | 0.773446 | 4 | 0 | 4 |
| PRLR | NHLH1 | 0.766656 | 4 | 0 | 4 |
| PRLR | TAF6L | 0.751016 | 3 | 0 | 3 |
| PRLR | OPRM1 | 0.724568 | 3 | 0 | 3 |
| PRLR | LYZL6 | 0.713679 | 3 | 0 | 3 |
| PRLR | GRAMD1B | 0.711934 | 3 | 0 | 3 |
| PRLR | CRHR2 | 0.703265 | 3 | 0 | 3 |
| PRLR | CD180 | 0.702053 | 3 | 0 | 3 |
| PRLR | SLC6A12 | 0.700351 | 4 | 0 | 4 |
| PRLR | TEX15 | 0.700189 | 3 | 0 | 3 |
| PRLR | PTPRJ | 0.698123 | 5 | 0 | 5 |
| PRLR | POLN | 0.697156 | 3 | 0 | 3 |
| PRLR | ZMAT4 | 0.696261 | 4 | 0 | 4 |
| PRLR | OR51E2 | 0.695808 | 4 | 0 | 4 |
| PRLR | CHST4 | 0.694939 | 6 | 0 | 5 |
| PRLR | PODNL1 | 0.692409 | 4 | 0 | 4 |
| PRLR | CRX | 0.691861 | 4 | 0 | 3 |
| PRLR | SAG | 0.69072 | 5 | 0 | 4 |
| PRLR | SIX6 | 0.688956 | 4 | 0 | 4 |
| PRLR | MAPK11 | 0.682726 | 4 | 0 | 4 |
For details and further investigation, click here
