IFNG

 

Full name: interferon gamma Alias Symbol: 
Type: protein-coding gene Cytoband: 12q15
Entrez ID: 3458 HGNC ID: HGNC:5438 Ensembl Gene: ENSG00000111537 OMIM ID: 147570
Drug and gene relationship at DGIdb

 

IFNG involved pathways:

KEGG pathway Description View
hsa04066HIF-1 signaling pathway
hsa04350TGF-beta signaling pathway
hsa04380Osteoclast differentiation
hsa04612Antigen processing and presentation
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05132Salmonella infection
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05162Measles
hsa05321Inflammatory bowel disease (IBD)

 

Expression of IFNG:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IFNG 3458 210354_at 0.0526 0.9687
GSE20347 IFNG 3458 210354_at 0.2384 0.1561
GSE23400 IFNG 3458 210354_at -0.0031 0.9447
GSE26886 IFNG 3458 210354_at -0.0465 0.8691
GSE29001 IFNG 3458 210354_at 0.0845 0.6534
GSE38129 IFNG 3458 210354_at 0.1487 0.2101
GSE45670 IFNG 3458 210354_at 0.3619 0.1796
GSE53622 IFNG 3458 49485 0.5157 0.0056
GSE53624 IFNG 3458 49485 0.5517 0.0021
GSE63941 IFNG 3458 210354_at 0.1861 0.1466
GSE77861 IFNG 3458 210354_at -0.1507 0.0854
GSE97050 IFNG 3458 A_23_P151294 0.1910 0.3801
TCGA IFNG 3458 RNAseq 2.9879 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by IFNG expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IFNG:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IFNG 3458 6 0 24
GSE20123 IFNG 3458 6 0 24
GSE43470 IFNG 3458 5 0 38
GSE46452 IFNG 3458 13 0 46
GSE47630 IFNG 3458 10 1 29
GSE54993 IFNG 3458 0 8 62
GSE54994 IFNG 3458 7 1 45
GSE60625 IFNG 3458 0 0 11
GSE74703 IFNG 3458 5 0 31
GSE74704 IFNG 3458 5 0 15
TCGA IFNG 3458 24 9 63

Total number of gains: 81; Total number of losses: 19; Total Number of normals: 388.  

 

Somatic mutations of IFNG:

 

Generating mutation plots.

 

Highly correlated genes for IFNG:

 

Showing top 20/115 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IFNGGDF50.678972303
IFNGKLRC40.658022403
IFNGPRF10.649269807
IFNGBATF20.623803605
IFNGCXCL110.6221931108
IFNGAKAP50.617828705
IFNGAKAP8L0.616936303
IFNGTLR40.614152303
IFNGGBP50.613156604
IFNGLAG30.6065081007
IFNGKLRD10.599848807
IFNGCHRNA90.595883403
IFNGAHI10.594849403
IFNGEPSTI10.591897706
IFNGGBP40.591494806
IFNGNKG70.5913211208
IFNGGZMB0.5888071109
IFNGLRGUK0.587229403
IFNGSAMD30.581086605
IFNGCACNG30.576545403

For details and further investigation, click here