ISX

 

Full name: intestine specific homeobox Alias Symbol: RAXLX
Type: protein-coding gene Cytoband: 22q12.3
Entrez ID: 91464 HGNC ID: HGNC:28084 Ensembl Gene: ENSG00000175329 OMIM ID: 612019
Drug and gene relationship at DGIdb

 

Expression of ISX:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ISX 91464 232707_at -0.1020 0.6298
GSE26886 ISX 91464 232707_at 0.0602 0.6655
GSE45670 ISX 91464 232707_at -0.0450 0.6756
GSE53622 ISX 91464 83987 0.2767 0.3161
GSE53624 ISX 91464 83987 0.2280 0.0900
GSE63941 ISX 91464 232707_at 0.0824 0.5969
GSE77861 ISX 91464 232707_at -0.0293 0.7984
TCGA ISX 91464 RNAseq 1.2940 0.3195

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ISX expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ISX:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ISX 91464 4 4 22
GSE20123 ISX 91464 3 3 24
GSE43470 ISX 91464 4 6 33
GSE46452 ISX 91464 31 1 27
GSE47630 ISX 91464 8 5 27
GSE54993 ISX 91464 3 6 61
GSE54994 ISX 91464 9 9 35
GSE60625 ISX 91464 5 0 6
GSE74703 ISX 91464 4 5 27
GSE74704 ISX 91464 1 1 18
TCGA ISX 91464 28 15 53

Total number of gains: 100; Total number of losses: 55; Total Number of normals: 333.  

 

Somatic mutations of ISX:

 

Generating mutation plots.

 

Highly correlated genes for ISX:

 

Showing all 5 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ISXC17orf780.719912303
ISXZNF582-AS10.589569403
ISXABCC110.575062403
ISXLINC010070.541781403
ISXGAGE10.521647303

For details and further investigation, click here