PCDH15

 

Full name: protocadherin related 15 Alias Symbol: CDHR15
Type: protein-coding gene Cytoband: 10q21.1
Entrez ID: 65217 HGNC ID: HGNC:14674 Ensembl Gene: ENSG00000150275 OMIM ID: 605514
Drug and gene relationship at DGIdb

 

Expression of PCDH15:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PCDH15 65217 1560330_at 0.0198 0.9497
GSE26886 PCDH15 65217 1560330_at 0.1143 0.2898
GSE45670 PCDH15 65217 1560330_at 0.0604 0.4202
GSE53622 PCDH15 65217 77660 0.0588 0.6900
GSE53624 PCDH15 65217 77660 0.3903 0.0000
GSE63941 PCDH15 65217 1560330_at 0.0180 0.8722
GSE77861 PCDH15 65217 1553344_at 0.0154 0.8550
GSE97050 PCDH15 65217 A_33_P3258239 0.0727 0.8010
SRP133303 PCDH15 65217 RNAseq 1.2456 0.0007
TCGA PCDH15 65217 RNAseq 0.8232 0.1524

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PCDH15 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PCDH15:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PCDH15 65217 3 8 19
GSE20123 PCDH15 65217 3 8 19
GSE43470 PCDH15 65217 3 6 34
GSE46452 PCDH15 65217 0 13 46
GSE47630 PCDH15 65217 4 12 24
GSE54993 PCDH15 65217 9 0 61
GSE54994 PCDH15 65217 2 11 40
GSE60625 PCDH15 65217 0 0 11
GSE74703 PCDH15 65217 3 4 29
GSE74704 PCDH15 65217 1 6 13
TCGA PCDH15 65217 13 23 60

Total number of gains: 41; Total number of losses: 91; Total Number of normals: 356.  

 

Somatic mutations of PCDH15:

 

Generating mutation plots.

 

Highly correlated genes for PCDH15:

 

Showing all 5 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PCDH15OR4D10.670605303
PCDH15APTX0.654262303
PCDH15PVALB0.636773303
PCDH15PRCD0.614192303
PCDH15ENTPD1-AS10.511025303

For details and further investigation, click here