| Full name: aprataxin | Alias Symbol: FLJ20157|AOA|AOA1|EAOH|EOAHA | ||
| Type: protein-coding gene | Cytoband: 9p21.1 | ||
| Entrez ID: 54840 | HGNC ID: HGNC:15984 | Ensembl Gene: ENSG00000137074 | OMIM ID: 606350 |
| Drug and gene relationship at DGIdb | |||
Expression of APTX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APTX | 54840 | 218527_at | 0.5191 | 0.1767 | |
| GSE20347 | APTX | 54840 | 218527_at | 0.2205 | 0.1381 | |
| GSE23400 | APTX | 54840 | 218527_at | 0.5634 | 0.0000 | |
| GSE26886 | APTX | 54840 | 218527_at | -0.3576 | 0.1169 | |
| GSE29001 | APTX | 54840 | 218527_at | 0.5359 | 0.0750 | |
| GSE38129 | APTX | 54840 | 218527_at | 0.3234 | 0.0107 | |
| GSE45670 | APTX | 54840 | 218527_at | 0.5754 | 0.0027 | |
| GSE53622 | APTX | 54840 | 20970 | 0.4775 | 0.0000 | |
| GSE53624 | APTX | 54840 | 20970 | 0.7600 | 0.0000 | |
| GSE63941 | APTX | 54840 | 218527_at | 0.1087 | 0.7498 | |
| GSE77861 | APTX | 54840 | 218527_at | 0.5579 | 0.2738 | |
| GSE97050 | APTX | 54840 | A_23_P252775 | -0.0309 | 0.9019 | |
| SRP007169 | APTX | 54840 | RNAseq | 1.1431 | 0.0359 | |
| SRP008496 | APTX | 54840 | RNAseq | 1.1977 | 0.0006 | |
| SRP064894 | APTX | 54840 | RNAseq | 0.5883 | 0.0011 | |
| SRP133303 | APTX | 54840 | RNAseq | 0.2664 | 0.0546 | |
| SRP159526 | APTX | 54840 | RNAseq | -0.0246 | 0.9214 | |
| SRP193095 | APTX | 54840 | RNAseq | 0.0189 | 0.8737 | |
| SRP219564 | APTX | 54840 | RNAseq | 0.4067 | 0.2094 | |
| TCGA | APTX | 54840 | RNAseq | 0.1235 | 0.0658 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by APTX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APTX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APTX | 54840 | 3 | 15 | 12 | |
| GSE20123 | APTX | 54840 | 3 | 15 | 12 | |
| GSE43470 | APTX | 54840 | 4 | 10 | 29 | |
| GSE46452 | APTX | 54840 | 7 | 15 | 37 | |
| GSE47630 | APTX | 54840 | 1 | 21 | 18 | |
| GSE54993 | APTX | 54840 | 6 | 0 | 64 | |
| GSE54994 | APTX | 54840 | 7 | 11 | 35 | |
| GSE60625 | APTX | 54840 | 0 | 0 | 11 | |
| GSE74703 | APTX | 54840 | 3 | 7 | 26 | |
| GSE74704 | APTX | 54840 | 0 | 11 | 9 | |
| TCGA | APTX | 54840 | 16 | 45 | 35 |
Total number of gains: 50; Total number of losses: 150; Total Number of normals: 288.
Somatic mutations of APTX:
Generating mutation plots.
Highly correlated genes for APTX:
Showing top 20/177 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APTX | USP49 | 0.768711 | 3 | 0 | 3 |
| APTX | LRR1 | 0.742241 | 5 | 0 | 4 |
| APTX | CDK16 | 0.714313 | 3 | 0 | 3 |
| APTX | DPM3 | 0.706142 | 4 | 0 | 3 |
| APTX | TMEM104 | 0.702522 | 6 | 0 | 5 |
| APTX | CORT | 0.695519 | 3 | 0 | 3 |
| APTX | WDR90 | 0.686212 | 4 | 0 | 3 |
| APTX | SOX30 | 0.685508 | 3 | 0 | 3 |
| APTX | UBE2I | 0.685187 | 4 | 0 | 3 |
| APTX | C16orf91 | 0.683827 | 3 | 0 | 3 |
| APTX | CDCA5 | 0.677633 | 5 | 0 | 5 |
| APTX | ABT1 | 0.670912 | 5 | 0 | 4 |
| APTX | CECR2 | 0.664657 | 5 | 0 | 3 |
| APTX | PDCL | 0.661763 | 5 | 0 | 5 |
| APTX | PCDH15 | 0.654262 | 3 | 0 | 3 |
| APTX | LRWD1 | 0.653103 | 3 | 0 | 3 |
| APTX | RASL11B | 0.650589 | 5 | 0 | 4 |
| APTX | EDC3 | 0.648864 | 4 | 0 | 3 |
| APTX | GPR180 | 0.646175 | 4 | 0 | 3 |
| APTX | MED20 | 0.643883 | 9 | 0 | 8 |
For details and further investigation, click here
