PLA2G10

 

Full name: phospholipase A2 group X Alias Symbol: GXPLA2
Type: protein-coding gene Cytoband: 16p13.12
Entrez ID: 8399 HGNC ID: HGNC:9029 Ensembl Gene: ENSG00000069764 OMIM ID: 603603
Drug and gene relationship at DGIdb

 

PLA2G10 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04270Vascular smooth muscle contraction

 

Expression of PLA2G10:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 PLA2G10 8399 93130 0.4091 0.0834
GSE53624 PLA2G10 8399 93130 0.6188 0.0027
GSE97050 PLA2G10 A_21_P0011456 0.0714 0.7701
SRP133303 PLA2G10 8399 RNAseq 0.2680 0.3670
SRP159526 PLA2G10 8399 RNAseq 1.8348 0.0142
SRP219564 PLA2G10 8399 RNAseq 0.3766 0.4154
TCGA PLA2G10 8399 RNAseq -2.0203 0.0004

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by PLA2G10 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLA2G10:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLA2G10 8399 5 4 21
GSE20123 PLA2G10 8399 5 3 22
GSE43470 PLA2G10 8399 3 3 37
GSE46452 PLA2G10 8399 38 1 20
GSE47630 PLA2G10 8399 13 7 20
GSE54993 PLA2G10 8399 3 5 62
GSE54994 PLA2G10 8399 4 11 38
GSE60625 PLA2G10 8399 4 1 6
GSE74703 PLA2G10 8399 3 2 31
GSE74704 PLA2G10 8399 2 1 17
TCGA PLA2G10 8399 20 12 64

Total number of gains: 100; Total number of losses: 50; Total Number of normals: 338.  

 

Somatic mutations of PLA2G10:

 

Generating mutation plots.

 

Highly correlated genes for PLA2G10:

 

Showing all 5 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLA2G10TRIM310.731089303
PLA2G10PHGR10.702649303
PLA2G10KRT200.674898303
PLA2G10DNAJC220.656026303
PLA2G10CTSE0.617843303

For details and further investigation, click here