RPL5

 

Full name: ribosomal protein L5 Alias Symbol: L5|PPP1R135|uL18
Type: protein-coding gene Cytoband: 1p22.1
Entrez ID: 6125 HGNC ID: HGNC:10360 Ensembl Gene: ENSG00000122406 OMIM ID: 603634
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RPL5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 RPL5 6125 53612 -0.1647 0.0040
GSE53624 RPL5 6125 53612 -0.0981 0.1265
GSE97050 RPL5 6125 A_23_P12140 -0.0736 0.7632
SRP007169 RPL5 6125 RNAseq -0.9180 0.0144
SRP008496 RPL5 6125 RNAseq -0.8788 0.0000
SRP064894 RPL5 6125 RNAseq -0.3858 0.0937
SRP133303 RPL5 6125 RNAseq -0.6586 0.0000
SRP159526 RPL5 6125 RNAseq -0.9903 0.0000
SRP193095 RPL5 6125 RNAseq -0.8167 0.0000
SRP219564 RPL5 6125 RNAseq -0.5698 0.0378
TCGA RPL5 6125 RNAseq -0.0686 0.0798

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by RPL5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RPL5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RPL5 6125 0 8 22
GSE20123 RPL5 6125 0 8 22
GSE43470 RPL5 6125 2 6 35
GSE46452 RPL5 6125 1 1 57
GSE47630 RPL5 6125 8 5 27
GSE54993 RPL5 6125 0 1 69
GSE54994 RPL5 6125 6 3 44
GSE60625 RPL5 6125 0 0 11
GSE74703 RPL5 6125 1 5 30
GSE74704 RPL5 6125 0 5 15
TCGA RPL5 6125 6 24 66

Total number of gains: 24; Total number of losses: 66; Total Number of normals: 398.  

 

Somatic mutations of RPL5:

 

Generating mutation plots.

 

Highly correlated genes for RPL5:

 

Showing all 3 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RPL5RPL60.627738303
RPL5RPS3A0.574102303
RPL5RPL40.552842303

For details and further investigation, click here