RPL4

 

Full name: ribosomal protein L4 Alias Symbol: L4
Type: protein-coding gene Cytoband: 15q22.31
Entrez ID: 6124 HGNC ID: HGNC:10353 Ensembl Gene: ENSG00000174444 OMIM ID: 180479
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RPL4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 RPL4 6124 32105 0.2132 0.0067
GSE53624 RPL4 6124 32105 0.2437 0.0001
GSE97050 RPL4 6124 A_23_P69431 -0.0751 0.7445
SRP007169 RPL4 6124 RNAseq -0.5685 0.0959
SRP008496 RPL4 6124 RNAseq -0.5076 0.0497
SRP064894 RPL4 6124 RNAseq -0.4403 0.0949
SRP133303 RPL4 6124 RNAseq -0.4943 0.0013
SRP159526 RPL4 6124 RNAseq -0.8155 0.0191
SRP193095 RPL4 6124 RNAseq -0.8160 0.0000
SRP219564 RPL4 6124 RNAseq -0.4871 0.2419
TCGA RPL4 6124 RNAseq -0.0078 0.8474

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by RPL4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RPL4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RPL4 6124 7 3 20
GSE20123 RPL4 6124 7 3 20
GSE43470 RPL4 6124 4 6 33
GSE46452 RPL4 6124 3 7 49
GSE47630 RPL4 6124 8 10 22
GSE54993 RPL4 6124 5 6 59
GSE54994 RPL4 6124 6 7 40
GSE60625 RPL4 6124 4 0 7
GSE74703 RPL4 6124 4 3 29
GSE74704 RPL4 6124 3 3 14
TCGA RPL4 6124 9 16 71

Total number of gains: 60; Total number of losses: 64; Total Number of normals: 364.  

 

Somatic mutations of RPL4:

 

Generating mutation plots.

 

Highly correlated genes for RPL4:

 

Showing all 7 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RPL4RPS270.707658303
RPL4RPL35A0.674637303
RPL4RPL240.665136303
RPL4RPL120.645948303
RPL4RPS150.633013303
RPL4RPL350.596304303
RPL4RPL50.552842303

For details and further investigation, click here