SPZ1

 

Full name: spermatogenic leucine zipper 1 Alias Symbol: NYD-TSP1|FLJ25709|PPP1R148
Type: protein-coding gene Cytoband: 5q14.1
Entrez ID: 84654 HGNC ID: HGNC:30721 Ensembl Gene: ENSG00000164299 OMIM ID: 618068
Drug and gene relationship at DGIdb

 

Expression of SPZ1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SPZ1 84654 224167_at 0.0462 0.8352
GSE26886 SPZ1 84654 224167_at 0.1336 0.2801
GSE45670 SPZ1 84654 224167_at 0.1499 0.4524
GSE53622 SPZ1 84654 82387 0.1155 0.4489
GSE53624 SPZ1 84654 82387 -0.1416 0.3486
GSE63941 SPZ1 84654 224167_at 0.1411 0.6270
GSE77861 SPZ1 84654 224167_at 0.1342 0.4918
TCGA SPZ1 84654 RNAseq 2.8249 0.0752

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SPZ1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SPZ1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SPZ1 84654 1 13 16
GSE20123 SPZ1 84654 1 13 16
GSE43470 SPZ1 84654 1 11 31
GSE46452 SPZ1 84654 0 28 31
GSE47630 SPZ1 84654 1 19 20
GSE54993 SPZ1 84654 8 1 61
GSE54994 SPZ1 84654 2 19 32
GSE60625 SPZ1 84654 0 0 11
GSE74703 SPZ1 84654 1 7 28
GSE74704 SPZ1 84654 1 6 13
TCGA SPZ1 84654 5 49 42

Total number of gains: 21; Total number of losses: 166; Total Number of normals: 301.  

 

Somatic mutations of SPZ1:

 

Generating mutation plots.

 

Highly correlated genes for SPZ1:

 

Showing all 4 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SPZ1NECAB30.663752303
SPZ1ZNF280C0.58872303
SPZ1A1BG0.565794403
SPZ1PLEKHG4B0.547639303

For details and further investigation, click here