| Full name: pleckstrin homology and RhoGEF domain containing G4B | Alias Symbol: KIAA1909 | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 153478 | HGNC ID: HGNC:29399 | Ensembl Gene: ENSG00000153404 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHG4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHG4B | 153478 | 230441_at | 1.9800 | 0.0700 | |
| GSE26886 | PLEKHG4B | 153478 | 230441_at | 2.3882 | 0.0000 | |
| GSE45670 | PLEKHG4B | 153478 | 230441_at | 0.9337 | 0.0026 | |
| GSE53622 | PLEKHG4B | 153478 | 37528 | 2.1201 | 0.0000 | |
| GSE53624 | PLEKHG4B | 153478 | 37528 | 1.6437 | 0.0000 | |
| GSE63941 | PLEKHG4B | 153478 | 230441_at | 1.2592 | 0.1673 | |
| GSE77861 | PLEKHG4B | 153478 | 236255_at | 0.1369 | 0.3674 | |
| GSE97050 | PLEKHG4B | 153478 | A_33_P3746549 | 1.5973 | 0.1189 | |
| SRP007169 | PLEKHG4B | 153478 | RNAseq | 3.5242 | 0.0000 | |
| SRP064894 | PLEKHG4B | 153478 | RNAseq | 1.9663 | 0.0000 | |
| SRP133303 | PLEKHG4B | 153478 | RNAseq | 1.7824 | 0.0001 | |
| SRP159526 | PLEKHG4B | 153478 | RNAseq | 3.7088 | 0.0000 | |
| SRP193095 | PLEKHG4B | 153478 | RNAseq | 1.8188 | 0.0000 | |
| SRP219564 | PLEKHG4B | 153478 | RNAseq | 2.6708 | 0.0001 | |
| TCGA | PLEKHG4B | 153478 | RNAseq | 0.8263 | 0.0048 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by PLEKHG4B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHG4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHG4B | 153478 | 12 | 2 | 16 | |
| GSE20123 | PLEKHG4B | 153478 | 12 | 1 | 17 | |
| GSE43470 | PLEKHG4B | 153478 | 16 | 0 | 27 | |
| GSE46452 | PLEKHG4B | 153478 | 6 | 22 | 31 | |
| GSE47630 | PLEKHG4B | 153478 | 11 | 9 | 20 | |
| GSE54993 | PLEKHG4B | 153478 | 5 | 6 | 59 | |
| GSE54994 | PLEKHG4B | 153478 | 29 | 1 | 23 | |
| GSE60625 | PLEKHG4B | 153478 | 0 | 0 | 11 | |
| GSE74703 | PLEKHG4B | 153478 | 13 | 0 | 23 | |
| GSE74704 | PLEKHG4B | 153478 | 11 | 0 | 9 | |
| TCGA | PLEKHG4B | 153478 | 60 | 4 | 32 |
Total number of gains: 175; Total number of losses: 45; Total Number of normals: 268.
Somatic mutations of PLEKHG4B:
Generating mutation plots.
Highly correlated genes for PLEKHG4B:
Showing top 20/945 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHG4B | MPLKIP | 0.781547 | 3 | 0 | 3 |
| PLEKHG4B | KREMEN2 | 0.740773 | 4 | 0 | 3 |
| PLEKHG4B | ACVR1C | 0.738466 | 3 | 0 | 3 |
| PLEKHG4B | MYH10 | 0.71001 | 4 | 0 | 4 |
| PLEKHG4B | KDM6B | 0.707555 | 3 | 0 | 3 |
| PLEKHG4B | PTK7 | 0.704556 | 7 | 0 | 7 |
| PLEKHG4B | SLC19A1 | 0.704243 | 3 | 0 | 3 |
| PLEKHG4B | EXT1 | 0.6982 | 6 | 0 | 6 |
| PLEKHG4B | CAMKK1 | 0.696433 | 3 | 0 | 3 |
| PLEKHG4B | POSTN | 0.695216 | 5 | 0 | 5 |
| PLEKHG4B | RAB13 | 0.692769 | 3 | 0 | 3 |
| PLEKHG4B | HOXD11 | 0.687616 | 8 | 0 | 7 |
| PLEKHG4B | IGF2BP2 | 0.6861 | 6 | 0 | 6 |
| PLEKHG4B | BGN | 0.684028 | 6 | 0 | 6 |
| PLEKHG4B | GTSE1 | 0.683522 | 7 | 0 | 7 |
| PLEKHG4B | TMC8 | 0.681675 | 4 | 0 | 3 |
| PLEKHG4B | CTHRC1 | 0.68123 | 7 | 0 | 5 |
| PLEKHG4B | COL10A1 | 0.67738 | 6 | 0 | 5 |
| PLEKHG4B | INTS1 | 0.675377 | 4 | 0 | 4 |
| PLEKHG4B | COL7A1 | 0.67494 | 7 | 0 | 6 |
For details and further investigation, click here
