APLF

 

Full name: aprataxin and PNKP like factor Alias Symbol: MGC47799|Xip1|ZCCHH1
Type: protein-coding gene Cytoband: 2p13.3
Entrez ID: 200558 HGNC ID: HGNC:28724 Ensembl Gene: ENSG00000169621 OMIM ID: 611035
Drug and gene relationship at DGIdb

 

Expression of APLF:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 APLF 200558 1555100_at -0.0937 0.7449
GSE26886 APLF 200558 1555100_at -0.1047 0.2531
GSE45670 APLF 200558 1555100_at 0.0776 0.4410
GSE53622 APLF 200558 89129 -0.9250 0.0000
GSE53624 APLF 200558 89129 -0.8754 0.0000
GSE63941 APLF 200558 1555100_at -0.2651 0.1311
GSE77861 APLF 200558 1555100_at -0.0486 0.7468
SRP007169 APLF 200558 RNAseq -2.6897 0.0000
SRP008496 APLF 200558 RNAseq -1.3975 0.0008
SRP064894 APLF 200558 RNAseq -0.4330 0.0164
SRP133303 APLF 200558 RNAseq -0.3966 0.0305
SRP159526 APLF 200558 RNAseq -0.3907 0.2773
SRP193095 APLF 200558 RNAseq -0.9079 0.0000
SRP219564 APLF 200558 RNAseq -0.3704 0.2523
TCGA APLF 200558 RNAseq 0.4079 0.0002

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by APLF expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of APLF:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 APLF 200558 11 0 19
GSE20123 APLF 200558 11 0 19
GSE43470 APLF 200558 6 0 37
GSE46452 APLF 200558 2 3 54
GSE47630 APLF 200558 7 0 33
GSE54993 APLF 200558 0 6 64
GSE54994 APLF 200558 12 0 41
GSE60625 APLF 200558 0 3 8
GSE74703 APLF 200558 6 0 30
GSE74704 APLF 200558 9 0 11
TCGA APLF 200558 36 2 58

Total number of gains: 100; Total number of losses: 14; Total Number of normals: 374.  

 

Somatic mutations of APLF:

 

Generating mutation plots.

 

Highly correlated genes for APLF:

 

Showing all 5 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
APLFPRKG1-AS10.572424303
APLFFGF220.56936303
APLFZNF6540.526818303
APLFMTMR30.515428503
APLFSCOC0.506945403

For details and further investigation, click here