| Full name: short coiled-coil protein | Alias Symbol: HRIHFB2072|SCOCO|UNC-69 | ||
| Type: protein-coding gene | Cytoband: 4q31.1 | ||
| Entrez ID: 60592 | HGNC ID: HGNC:20335 | Ensembl Gene: ENSG00000153130 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SCOC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCOC | 60592 | 224786_at | -0.2666 | 0.2460 | |
| GSE26886 | SCOC | 60592 | 224786_at | -1.0800 | 0.0000 | |
| GSE45670 | SCOC | 60592 | 224786_at | -0.4292 | 0.0049 | |
| GSE53622 | SCOC | 60592 | 20922 | -0.6231 | 0.0000 | |
| GSE53624 | SCOC | 60592 | 20922 | -0.8061 | 0.0000 | |
| GSE63941 | SCOC | 60592 | 224786_at | -0.8533 | 0.0164 | |
| GSE77861 | SCOC | 60592 | 224786_at | -0.7315 | 0.0791 | |
| GSE97050 | SCOC | 60592 | A_24_P46334 | -0.1565 | 0.6196 | |
| SRP007169 | SCOC | 60592 | RNAseq | -1.5125 | 0.0004 | |
| SRP008496 | SCOC | 60592 | RNAseq | -1.1629 | 0.0000 | |
| SRP064894 | SCOC | 60592 | RNAseq | -0.6845 | 0.0000 | |
| SRP133303 | SCOC | 60592 | RNAseq | 0.1282 | 0.5712 | |
| SRP159526 | SCOC | 60592 | RNAseq | -0.4009 | 0.0182 | |
| SRP193095 | SCOC | 60592 | RNAseq | -0.8708 | 0.0000 | |
| SRP219564 | SCOC | 60592 | RNAseq | -0.9066 | 0.0002 | |
| TCGA | SCOC | 60592 | RNAseq | -0.0517 | 0.3301 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by SCOC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCOC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCOC | 60592 | 0 | 12 | 18 | |
| GSE20123 | SCOC | 60592 | 0 | 12 | 18 | |
| GSE43470 | SCOC | 60592 | 0 | 13 | 30 | |
| GSE46452 | SCOC | 60592 | 1 | 36 | 22 | |
| GSE47630 | SCOC | 60592 | 0 | 22 | 18 | |
| GSE54993 | SCOC | 60592 | 10 | 0 | 60 | |
| GSE54994 | SCOC | 60592 | 2 | 11 | 40 | |
| GSE60625 | SCOC | 60592 | 0 | 1 | 10 | |
| GSE74703 | SCOC | 60592 | 0 | 11 | 25 | |
| GSE74704 | SCOC | 60592 | 0 | 6 | 14 | |
| TCGA | SCOC | 60592 | 12 | 31 | 53 |
Total number of gains: 25; Total number of losses: 155; Total Number of normals: 308.
Somatic mutations of SCOC:
Generating mutation plots.
Highly correlated genes for SCOC:
Showing top 20/1267 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCOC | IMPACT | 0.811359 | 3 | 0 | 3 |
| SCOC | TP53RK | 0.804364 | 3 | 0 | 3 |
| SCOC | DPY19L3 | 0.801418 | 3 | 0 | 3 |
| SCOC | YTHDF2 | 0.794644 | 3 | 0 | 3 |
| SCOC | NAA35 | 0.788649 | 3 | 0 | 3 |
| SCOC | DHX15 | 0.788589 | 3 | 0 | 3 |
| SCOC | TMEM218 | 0.766326 | 3 | 0 | 3 |
| SCOC | NDEL1 | 0.764411 | 3 | 0 | 3 |
| SCOC | CCNYL1 | 0.763171 | 4 | 0 | 4 |
| SCOC | TPD52L2 | 0.761794 | 3 | 0 | 3 |
| SCOC | NFXL1 | 0.758255 | 3 | 0 | 3 |
| SCOC | PCSK5 | 0.754424 | 3 | 0 | 3 |
| SCOC | RALGAPB | 0.753249 | 3 | 0 | 3 |
| SCOC | TAB3 | 0.747737 | 7 | 0 | 6 |
| SCOC | GTF2A1 | 0.746286 | 3 | 0 | 3 |
| SCOC | UBQLN1 | 0.738829 | 3 | 0 | 3 |
| SCOC | ARHGAP1 | 0.73548 | 3 | 0 | 3 |
| SCOC | TTLL4 | 0.735048 | 3 | 0 | 3 |
| SCOC | ARFIP1 | 0.730707 | 8 | 0 | 8 |
| SCOC | PPP2CB | 0.725712 | 7 | 0 | 7 |
For details and further investigation, click here
