| Full name: fibroblast growth factor 22 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 27006 | HGNC ID: HGNC:3679 | Ensembl Gene: ENSG00000070388 | OMIM ID: 605831 |
| Drug and gene relationship at DGIdb | |||
FGF22 involved pathways:
Expression of FGF22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGF22 | 27006 | 1566816_at | -0.0109 | 0.9690 | |
| GSE20347 | FGF22 | 27006 | 221315_s_at | -0.0190 | 0.8075 | |
| GSE23400 | FGF22 | 27006 | 221315_s_at | -0.1932 | 0.0000 | |
| GSE26886 | FGF22 | 27006 | 1566816_at | -0.1780 | 0.1217 | |
| GSE29001 | FGF22 | 27006 | 221315_s_at | -0.0438 | 0.7088 | |
| GSE38129 | FGF22 | 27006 | 221315_s_at | -0.0704 | 0.2347 | |
| GSE45670 | FGF22 | 27006 | 1566816_at | 0.0471 | 0.6900 | |
| GSE53622 | FGF22 | 27006 | 5262 | 0.3134 | 0.0029 | |
| GSE53624 | FGF22 | 27006 | 5262 | 0.3952 | 0.0020 | |
| GSE63941 | FGF22 | 27006 | 1566816_at | -0.0186 | 0.9016 | |
| GSE77861 | FGF22 | 27006 | 221315_s_at | -0.1247 | 0.2338 | |
| GSE97050 | FGF22 | 27006 | A_33_P3297907 | 0.0751 | 0.7511 | |
| SRP219564 | FGF22 | 27006 | RNAseq | -3.0640 | 0.0000 | |
| TCGA | FGF22 | 27006 | RNAseq | 0.5817 | 0.5719 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FGF22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGF22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGF22 | 27006 | 4 | 6 | 20 | |
| GSE20123 | FGF22 | 27006 | 4 | 5 | 21 | |
| GSE43470 | FGF22 | 27006 | 1 | 10 | 32 | |
| GSE46452 | FGF22 | 27006 | 47 | 1 | 11 | |
| GSE47630 | FGF22 | 27006 | 5 | 7 | 28 | |
| GSE54993 | FGF22 | 27006 | 13 | 4 | 53 | |
| GSE54994 | FGF22 | 27006 | 8 | 15 | 30 | |
| GSE60625 | FGF22 | 27006 | 9 | 0 | 2 | |
| GSE74703 | FGF22 | 27006 | 1 | 7 | 28 | |
| GSE74704 | FGF22 | 27006 | 3 | 3 | 14 | |
| TCGA | FGF22 | 27006 | 8 | 25 | 63 |
Total number of gains: 103; Total number of losses: 83; Total Number of normals: 302.
Somatic mutations of FGF22:
Generating mutation plots.
Highly correlated genes for FGF22:
Showing top 20/618 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGF22 | STRC | 0.806317 | 3 | 0 | 3 |
| FGF22 | JSRP1 | 0.803638 | 3 | 0 | 3 |
| FGF22 | NTNG2 | 0.797862 | 3 | 0 | 3 |
| FGF22 | C2CD4D | 0.78279 | 3 | 0 | 3 |
| FGF22 | PNPLA7 | 0.780975 | 3 | 0 | 3 |
| FGF22 | CELF3 | 0.776413 | 3 | 0 | 3 |
| FGF22 | SH2D1B | 0.767175 | 3 | 0 | 3 |
| FGF22 | ANKDD1A | 0.763829 | 3 | 0 | 3 |
| FGF22 | PLA2G2C | 0.762041 | 3 | 0 | 3 |
| FGF22 | PRR18 | 0.761037 | 3 | 0 | 3 |
| FGF22 | KCTD19 | 0.755874 | 3 | 0 | 3 |
| FGF22 | FMR1NB | 0.75317 | 3 | 0 | 3 |
| FGF22 | TOR2A | 0.745317 | 3 | 0 | 3 |
| FGF22 | LRRC10 | 0.743537 | 3 | 0 | 3 |
| FGF22 | TCTE1 | 0.74293 | 4 | 0 | 4 |
| FGF22 | TEX13A | 0.737047 | 4 | 0 | 3 |
| FGF22 | RBAKDN | 0.735725 | 3 | 0 | 3 |
| FGF22 | SPACA3 | 0.730027 | 5 | 0 | 4 |
| FGF22 | CPN1 | 0.729337 | 4 | 0 | 4 |
| FGF22 | CD72 | 0.72869 | 3 | 0 | 3 |
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