DDR1

 

Full name: discoidin domain receptor tyrosine kinase 1 Alias Symbol: RTK6|CD167
Type: protein-coding gene Cytoband: 6p21.33
Entrez ID: 780 HGNC ID: HGNC:2730 Ensembl Gene: ENSG00000204580 OMIM ID: 600408
Drug and gene relationship at DGIdb

 

Expression of DDR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 DDR1 780 22091 0.4673 0.0007
GSE53624 DDR1 780 22091 0.4600 0.0000
GSE97050 DDR1 780 A_23_P93311 0.6857 0.3499
SRP007169 DDR1 780 RNAseq 0.2946 0.4429
SRP008496 DDR1 780 RNAseq 0.2767 0.2057
SRP064894 DDR1 780 RNAseq -0.1334 0.6291
SRP133303 DDR1 780 RNAseq 0.1484 0.5473
SRP159526 DDR1 780 RNAseq 0.8186 0.0000
SRP193095 DDR1 780 RNAseq 0.3068 0.0259
SRP219564 DDR1 780 RNAseq -0.0427 0.9413
TCGA DDR1 780 RNAseq 0.2116 0.0002

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by DDR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DDR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DDR1 780 5 1 24
GSE20123 DDR1 780 5 1 24
GSE43470 DDR1 780 6 1 36
GSE46452 DDR1 780 1 10 48
GSE47630 DDR1 780 7 3 30
GSE54993 DDR1 780 2 1 67
GSE54994 DDR1 780 11 4 38
GSE60625 DDR1 780 0 1 10
GSE74703 DDR1 780 6 0 30
GSE74704 DDR1 780 2 0 18
TCGA DDR1 780 18 16 62

Total number of gains: 63; Total number of losses: 38; Total Number of normals: 387.  

 

Somatic mutations of DDR1:

 

Generating mutation plots.

 

Highly correlated genes for DDR1:

 

Showing all 4 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DDR1F11R0.763019303
DDR1ABCC100.612149303
DDR1COL7A10.610704303
DDR1DUS1L0.534684403

For details and further investigation, click here