| Full name: F11 receptor | Alias Symbol: PAM-1|JCAM|JAM-1|JAM-A|JAMA|CD321 | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 50848 | HGNC ID: HGNC:14685 | Ensembl Gene: ENSG00000158769 | OMIM ID: 605721 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
F11R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of F11R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | F11R | 50848 | 223000_s_at | 0.7783 | 0.2055 | |
| GSE20347 | F11R | 50848 | 221664_s_at | 0.0459 | 0.7984 | |
| GSE23400 | F11R | 50848 | 221664_s_at | 0.3441 | 0.0038 | |
| GSE26886 | F11R | 50848 | 223000_s_at | 0.4885 | 0.0011 | |
| GSE29001 | F11R | 50848 | 221664_s_at | -0.0794 | 0.7948 | |
| GSE38129 | F11R | 50848 | 221664_s_at | 0.8131 | 0.0051 | |
| GSE45670 | F11R | 50848 | 223000_s_at | 0.4088 | 0.0047 | |
| GSE53622 | F11R | 50848 | 119787 | 0.2841 | 0.0225 | |
| GSE53624 | F11R | 50848 | 119787 | 0.2905 | 0.0000 | |
| GSE63941 | F11R | 50848 | 223000_s_at | 3.8896 | 0.0018 | |
| GSE77861 | F11R | 50848 | 223000_s_at | 0.6707 | 0.0032 | |
| GSE97050 | F11R | 50848 | A_33_P3238250 | 0.9238 | 0.2660 | |
| SRP007169 | F11R | 50848 | RNAseq | -0.7541 | 0.0487 | |
| SRP008496 | F11R | 50848 | RNAseq | -0.3824 | 0.1125 | |
| SRP064894 | F11R | 50848 | RNAseq | -0.3439 | 0.1549 | |
| SRP133303 | F11R | 50848 | RNAseq | 0.4149 | 0.0642 | |
| SRP159526 | F11R | 50848 | RNAseq | 0.5885 | 0.0585 | |
| SRP193095 | F11R | 50848 | RNAseq | 0.0783 | 0.5929 | |
| SRP219564 | F11R | 50848 | RNAseq | 0.1871 | 0.8105 | |
| TCGA | F11R | 50848 | RNAseq | 0.2749 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by F11R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of F11R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | F11R | 50848 | 10 | 0 | 20 | |
| GSE20123 | F11R | 50848 | 10 | 0 | 20 | |
| GSE43470 | F11R | 50848 | 7 | 2 | 34 | |
| GSE46452 | F11R | 50848 | 2 | 1 | 56 | |
| GSE47630 | F11R | 50848 | 14 | 0 | 26 | |
| GSE54993 | F11R | 50848 | 0 | 6 | 64 | |
| GSE54994 | F11R | 50848 | 16 | 0 | 37 | |
| GSE60625 | F11R | 50848 | 0 | 0 | 11 | |
| GSE74703 | F11R | 50848 | 7 | 2 | 27 | |
| GSE74704 | F11R | 50848 | 4 | 0 | 16 | |
| TCGA | F11R | 50848 | 45 | 3 | 48 |
Total number of gains: 115; Total number of losses: 14; Total Number of normals: 359.
Somatic mutations of F11R:
Generating mutation plots.
Highly correlated genes for F11R:
Showing top 20/772 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| F11R | DDR1 | 0.763019 | 3 | 0 | 3 |
| F11R | GATC | 0.722061 | 3 | 0 | 3 |
| F11R | MYBBP1A | 0.721842 | 5 | 0 | 5 |
| F11R | AATF | 0.719429 | 3 | 0 | 3 |
| F11R | MED30 | 0.717285 | 3 | 0 | 3 |
| F11R | ABRACL | 0.712329 | 4 | 0 | 4 |
| F11R | TP63 | 0.707277 | 10 | 0 | 10 |
| F11R | UBALD2 | 0.699122 | 3 | 0 | 3 |
| F11R | GRHL2 | 0.698425 | 8 | 0 | 6 |
| F11R | CDH1 | 0.698183 | 8 | 0 | 6 |
| F11R | FGFR3 | 0.697967 | 5 | 0 | 5 |
| F11R | UNC93B1 | 0.69777 | 5 | 0 | 4 |
| F11R | FXYD3 | 0.693842 | 10 | 0 | 8 |
| F11R | SMCR8 | 0.691916 | 3 | 0 | 3 |
| F11R | MCMBP | 0.691738 | 3 | 0 | 3 |
| F11R | EFTUD2 | 0.691449 | 5 | 0 | 5 |
| F11R | ST14 | 0.687377 | 7 | 0 | 6 |
| F11R | IRF6 | 0.686439 | 10 | 0 | 8 |
| F11R | FAM83H | 0.686162 | 7 | 0 | 6 |
| F11R | ARRDC1 | 0.683844 | 4 | 0 | 4 |
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