COL7A1

 

Full name: collagen type VII alpha 1 chain Alias Symbol: 
Type: protein-coding gene Cytoband: 3p21.31
Entrez ID: 1294 HGNC ID: HGNC:2214 Ensembl Gene: ENSG00000114270 OMIM ID: 120120
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of COL7A1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 COL7A1 1294 217312_s_at 1.4513 0.0299
GSE20347 COL7A1 1294 217312_s_at 1.0158 0.0000
GSE23400 COL7A1 1294 217312_s_at 1.4895 0.0000
GSE26886 COL7A1 1294 204136_at 2.0140 0.0000
GSE29001 COL7A1 1294 204136_at 0.9619 0.0286
GSE38129 COL7A1 1294 217312_s_at 1.3513 0.0000
GSE45670 COL7A1 1294 204136_at 1.5345 0.0001
GSE53622 COL7A1 1294 38182 1.9987 0.0000
GSE53624 COL7A1 1294 38182 1.6102 0.0000
GSE63941 COL7A1 1294 204136_at 0.2445 0.7473
GSE77861 COL7A1 1294 204136_at 1.2222 0.0040
GSE97050 COL7A1 1294 A_23_P144071 0.8826 0.2087
SRP007169 COL7A1 1294 RNAseq 3.3835 0.0000
SRP008496 COL7A1 1294 RNAseq 3.5269 0.0000
SRP064894 COL7A1 1294 RNAseq 1.8552 0.0000
SRP133303 COL7A1 1294 RNAseq 1.6081 0.0000
SRP159526 COL7A1 1294 RNAseq 2.0090 0.0002
SRP193095 COL7A1 1294 RNAseq 2.2896 0.0000
SRP219564 COL7A1 1294 RNAseq 1.0029 0.2261
TCGA COL7A1 1294 RNAseq 1.2933 0.0000

Upregulated datasets: 16; Downregulated datasets: 0.  

 

Survival by COL7A1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of COL7A1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 COL7A1 1294 0 18 12
GSE20123 COL7A1 1294 0 19 11
GSE43470 COL7A1 1294 0 19 24
GSE46452 COL7A1 1294 3 16 40
GSE47630 COL7A1 1294 1 24 15
GSE54993 COL7A1 1294 6 2 62
GSE54994 COL7A1 1294 0 36 17
GSE60625 COL7A1 1294 5 0 6
GSE74703 COL7A1 1294 0 15 21
GSE74704 COL7A1 1294 0 12 8
TCGA COL7A1 1294 0 78 18

Total number of gains: 15; Total number of losses: 239; Total Number of normals: 234.  

 

Somatic mutations of COL7A1:

 

Generating mutation plots.

 

Highly correlated genes for COL7A1:

 

Showing top 20/1492 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
COL7A1FZD60.775498606
COL7A1LAMC20.77537511011
COL7A1ITGB40.76684411011
COL7A1WDR660.762597707
COL7A1CLIC40.761078303
COL7A1PTK70.75713811011
COL7A1MTERF30.75094707
COL7A1AGRN0.75085111011
COL7A1HOMER30.74421611011
COL7A1KRT170.735002303
COL7A1MYO100.732831808
COL7A1LAMB30.7320612011
COL7A1CD2760.731073505
COL7A1TRIP130.72948510010
COL7A1CDH30.7280381009
COL7A1NCAPG0.722933707
COL7A1SLC39A30.722759303
COL7A1POLR1A0.720749303
COL7A1BOP10.72072303
COL7A1SLC20A10.718729808

For details and further investigation, click here