HCAR1

 

Full name: hydroxycarboxylic acid receptor 1 Alias Symbol: HCA1|FKSG80|TA-GPCR|LACR1
Type: protein-coding gene Cytoband: 12q24.31
Entrez ID: 27198 HGNC ID: HGNC:4532 Ensembl Gene: ENSG00000196917 OMIM ID: 606923
Drug and gene relationship at DGIdb

 

HCAR1 involved pathways:

KEGG pathway Description View
hsa04024cAMP signaling pathway

 

Expression of HCAR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HCAR1 27198 224131_at -0.1781 0.4593
GSE26886 HCAR1 27198 224131_at -0.0423 0.7314
GSE45670 HCAR1 27198 224131_at -0.0344 0.6546
GSE53622 HCAR1 27198 120086 -0.8585 0.0001
GSE53624 HCAR1 27198 120086 -1.1412 0.0000
GSE63941 HCAR1 27198 224131_at 0.1576 0.7072
GSE77861 HCAR1 27198 224131_at -0.0141 0.9098
SRP007169 HCAR1 27198 RNAseq 0.6035 0.4252
SRP064894 HCAR1 27198 RNAseq -0.2635 0.3145
SRP133303 HCAR1 27198 RNAseq -0.2212 0.2061
SRP159526 HCAR1 27198 RNAseq -0.3971 0.4801
SRP193095 HCAR1 27198 RNAseq -0.0633 0.6294
SRP219564 HCAR1 27198 RNAseq -0.3073 0.5238

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by HCAR1 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of HCAR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HCAR1 27198 5 5 20
GSE20123 HCAR1 27198 5 5 20
GSE43470 HCAR1 27198 2 1 40
GSE46452 HCAR1 27198 9 1 49
GSE47630 HCAR1 27198 9 3 28
GSE54993 HCAR1 27198 0 5 65
GSE54994 HCAR1 27198 4 8 41
GSE60625 HCAR1 27198 0 0 11
GSE74703 HCAR1 27198 2 0 34
GSE74704 HCAR1 27198 3 3 14
TCGA HCAR1 27198 21 10 65

Total number of gains: 60; Total number of losses: 41; Total Number of normals: 387.  

 

Somatic mutations of HCAR1:

 

Generating mutation plots.

 

Highly correlated genes for HCAR1:

 

Showing all 4 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HCAR1LMTK30.613584303
HCAR1BCL2L150.572386503
HCAR1CHMP50.569754303
HCAR1RNF1830.557655503

For details and further investigation, click here