| Full name: charged multivesicular body protein 5 | Alias Symbol: HSPC177|CGI-34|Vps60 | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 51510 | HGNC ID: HGNC:26942 | Ensembl Gene: ENSG00000086065 | OMIM ID: 610900 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CHMP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHMP5 | 51510 | 219356_s_at | -0.6242 | 0.1811 | |
| GSE20347 | CHMP5 | 51510 | 218085_at | -0.5017 | 0.0018 | |
| GSE23400 | CHMP5 | 51510 | 219356_s_at | -0.1309 | 0.1446 | |
| GSE26886 | CHMP5 | 51510 | 218085_at | -1.2832 | 0.0000 | |
| GSE29001 | CHMP5 | 51510 | 218085_at | 0.0374 | 0.9018 | |
| GSE38129 | CHMP5 | 51510 | 218085_at | -0.2965 | 0.0355 | |
| GSE45670 | CHMP5 | 51510 | 219356_s_at | 0.1010 | 0.5479 | |
| GSE53622 | CHMP5 | 51510 | 52145 | -0.2610 | 0.0003 | |
| GSE53624 | CHMP5 | 51510 | 52145 | -0.3417 | 0.0000 | |
| GSE63941 | CHMP5 | 51510 | 219356_s_at | -0.1212 | 0.7575 | |
| GSE77861 | CHMP5 | 51510 | 219356_s_at | -0.0881 | 0.8921 | |
| GSE97050 | CHMP5 | 51510 | A_33_P3296303 | 0.1773 | 0.4985 | |
| SRP007169 | CHMP5 | 51510 | RNAseq | -0.8811 | 0.0433 | |
| SRP008496 | CHMP5 | 51510 | RNAseq | -0.9284 | 0.0003 | |
| SRP064894 | CHMP5 | 51510 | RNAseq | -0.2192 | 0.2333 | |
| SRP133303 | CHMP5 | 51510 | RNAseq | -0.1338 | 0.3457 | |
| SRP159526 | CHMP5 | 51510 | RNAseq | -0.9277 | 0.0467 | |
| SRP193095 | CHMP5 | 51510 | RNAseq | -0.7628 | 0.0000 | |
| SRP219564 | CHMP5 | 51510 | RNAseq | -0.3321 | 0.5068 | |
| TCGA | CHMP5 | 51510 | RNAseq | 0.0374 | 0.4960 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CHMP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHMP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHMP5 | 51510 | 3 | 13 | 14 | |
| GSE20123 | CHMP5 | 51510 | 3 | 13 | 14 | |
| GSE43470 | CHMP5 | 51510 | 3 | 10 | 30 | |
| GSE46452 | CHMP5 | 51510 | 7 | 15 | 37 | |
| GSE47630 | CHMP5 | 51510 | 1 | 21 | 18 | |
| GSE54993 | CHMP5 | 51510 | 6 | 0 | 64 | |
| GSE54994 | CHMP5 | 51510 | 7 | 11 | 35 | |
| GSE60625 | CHMP5 | 51510 | 0 | 0 | 11 | |
| GSE74703 | CHMP5 | 51510 | 2 | 7 | 27 | |
| GSE74704 | CHMP5 | 51510 | 0 | 10 | 10 | |
| TCGA | CHMP5 | 51510 | 16 | 44 | 36 |
Total number of gains: 48; Total number of losses: 144; Total Number of normals: 296.
Somatic mutations of CHMP5:
Generating mutation plots.
Highly correlated genes for CHMP5:
Showing top 20/799 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHMP5 | ESYT2 | 0.81758 | 3 | 0 | 3 |
| CHMP5 | IMPACT | 0.804192 | 3 | 0 | 3 |
| CHMP5 | TRAPPC6B | 0.802565 | 3 | 0 | 3 |
| CHMP5 | WDFY1 | 0.786547 | 3 | 0 | 3 |
| CHMP5 | SLC10A7 | 0.771245 | 3 | 0 | 3 |
| CHMP5 | SLC22A15 | 0.760599 | 3 | 0 | 3 |
| CHMP5 | TMX3 | 0.756089 | 3 | 0 | 3 |
| CHMP5 | SLC18A2 | 0.753992 | 3 | 0 | 3 |
| CHMP5 | DNAJA1 | 0.74461 | 4 | 0 | 4 |
| CHMP5 | GBP6 | 0.736531 | 3 | 0 | 3 |
| CHMP5 | USP54 | 0.73187 | 3 | 0 | 3 |
| CHMP5 | UBE2D2 | 0.730714 | 4 | 0 | 3 |
| CHMP5 | C16orf72 | 0.727874 | 4 | 0 | 4 |
| CHMP5 | CPVL | 0.726409 | 3 | 0 | 3 |
| CHMP5 | MLLT10 | 0.724373 | 3 | 0 | 3 |
| CHMP5 | ZNF823 | 0.719383 | 4 | 0 | 4 |
| CHMP5 | P2RY13 | 0.716151 | 3 | 0 | 3 |
| CHMP5 | CCNYL1 | 0.716138 | 4 | 0 | 3 |
| CHMP5 | SOCS6 | 0.714039 | 5 | 0 | 5 |
| CHMP5 | HEMK1 | 0.710258 | 4 | 0 | 3 |
For details and further investigation, click here
