LINGO2

 

Full name: leucine rich repeat and Ig domain containing 2 Alias Symbol: LERN3
Type: protein-coding gene Cytoband: 9p21.2-p21.1
Entrez ID: 158038 HGNC ID: HGNC:21207 Ensembl Gene: ENSG00000174482 OMIM ID: 609793
Drug and gene relationship at DGIdb

 

Expression of LINGO2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LINGO2 158038 232720_at -0.0500 0.9107
GSE26886 LINGO2 158038 232720_at 0.8866 0.0366
GSE45670 LINGO2 158038 232720_at 0.2711 0.3468
GSE53622 LINGO2 158038 123253 0.2703 0.2195
GSE53624 LINGO2 158038 123253 0.6435 0.0001
GSE63941 LINGO2 158038 232720_at 0.1518 0.6231
GSE77861 LINGO2 158038 232720_at 0.0340 0.7914
SRP133303 LINGO2 158038 RNAseq 0.7838 0.0465
TCGA LINGO2 158038 RNAseq -1.1487 0.0653

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by LINGO2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LINGO2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LINGO2 158038 2 16 12
GSE20123 LINGO2 158038 2 16 12
GSE43470 LINGO2 158038 1 12 30
GSE46452 LINGO2 158038 6 18 35
GSE47630 LINGO2 158038 1 22 17
GSE54993 LINGO2 158038 7 0 63
GSE54994 LINGO2 158038 6 14 33
GSE60625 LINGO2 158038 0 0 11
GSE74703 LINGO2 158038 1 9 26
GSE74704 LINGO2 158038 0 12 8
TCGA LINGO2 158038 18 47 31

Total number of gains: 44; Total number of losses: 166; Total Number of normals: 278.  

 

Somatic mutations of LINGO2:

 

Generating mutation plots.

 

Highly correlated genes for LINGO2:

 

Showing all 4 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LINGO2CNTN50.628193303
LINGO2CHGB0.58075403
LINGO2DMRT20.556942303
LINGO2CDH80.544122403

For details and further investigation, click here