| Full name: chromogranin B | Alias Symbol: SgI | ||
| Type: protein-coding gene | Cytoband: 20p12.3 | ||
| Entrez ID: 1114 | HGNC ID: HGNC:1930 | Ensembl Gene: ENSG00000089199 | OMIM ID: 118920 |
| Drug and gene relationship at DGIdb | |||
Expression of CHGB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHGB | 1114 | 204260_at | 0.2751 | 0.8516 | |
| GSE20347 | CHGB | 1114 | 204260_at | 0.1824 | 0.0505 | |
| GSE23400 | CHGB | 1114 | 204260_at | -0.0658 | 0.2588 | |
| GSE26886 | CHGB | 1114 | 204260_at | 1.2232 | 0.0001 | |
| GSE29001 | CHGB | 1114 | 204260_at | 0.0679 | 0.6873 | |
| GSE38129 | CHGB | 1114 | 204260_at | 0.1395 | 0.6574 | |
| GSE45670 | CHGB | 1114 | 204260_at | 0.3142 | 0.3912 | |
| GSE53622 | CHGB | 1114 | 107953 | 0.7269 | 0.0017 | |
| GSE53624 | CHGB | 1114 | 107953 | 0.6122 | 0.0008 | |
| GSE63941 | CHGB | 1114 | 204260_at | 0.1003 | 0.9294 | |
| GSE77861 | CHGB | 1114 | 204260_at | 0.4424 | 0.4351 | |
| GSE97050 | CHGB | 1114 | A_23_P57155 | -0.0602 | 0.8581 | |
| SRP219564 | CHGB | 1114 | RNAseq | 1.9153 | 0.0612 | |
| TCGA | CHGB | 1114 | RNAseq | -1.4488 | 0.0016 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CHGB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHGB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHGB | 1114 | 11 | 2 | 17 | |
| GSE20123 | CHGB | 1114 | 11 | 2 | 17 | |
| GSE43470 | CHGB | 1114 | 12 | 1 | 30 | |
| GSE46452 | CHGB | 1114 | 26 | 1 | 32 | |
| GSE47630 | CHGB | 1114 | 18 | 4 | 18 | |
| GSE54993 | CHGB | 1114 | 1 | 14 | 55 | |
| GSE54994 | CHGB | 1114 | 25 | 2 | 26 | |
| GSE60625 | CHGB | 1114 | 0 | 0 | 11 | |
| GSE74703 | CHGB | 1114 | 9 | 1 | 26 | |
| GSE74704 | CHGB | 1114 | 5 | 1 | 14 | |
| TCGA | CHGB | 1114 | 40 | 11 | 45 |
Total number of gains: 158; Total number of losses: 39; Total Number of normals: 291.
Somatic mutations of CHGB:
Generating mutation plots.
Highly correlated genes for CHGB:
Showing top 20/185 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHGB | LINC00540 | 0.818044 | 3 | 0 | 3 |
| CHGB | IGFL2 | 0.811783 | 3 | 0 | 3 |
| CHGB | BST1 | 0.789242 | 3 | 0 | 3 |
| CHGB | PPFIA4 | 0.760309 | 3 | 0 | 3 |
| CHGB | DFFB | 0.742139 | 3 | 0 | 3 |
| CHGB | SHARPIN | 0.740108 | 3 | 0 | 3 |
| CHGB | PRR15 | 0.738879 | 3 | 0 | 3 |
| CHGB | TUBAL3 | 0.734283 | 3 | 0 | 3 |
| CHGB | LGR6 | 0.732187 | 3 | 0 | 3 |
| CHGB | PRPF31 | 0.726189 | 3 | 0 | 3 |
| CHGB | NAT14 | 0.725709 | 4 | 0 | 3 |
| CHGB | IER5L | 0.720328 | 3 | 0 | 3 |
| CHGB | IFT43 | 0.715648 | 4 | 0 | 4 |
| CHGB | KCNH8 | 0.706994 | 4 | 0 | 3 |
| CHGB | ZC3H10 | 0.705687 | 3 | 0 | 3 |
| CHGB | POLR3A | 0.705306 | 3 | 0 | 3 |
| CHGB | ARID3A | 0.703111 | 3 | 0 | 3 |
| CHGB | MAGEA8 | 0.694875 | 4 | 0 | 4 |
| CHGB | CCDC28B | 0.679663 | 3 | 0 | 3 |
| CHGB | SPTA1 | 0.678451 | 5 | 0 | 4 |
For details and further investigation, click here
