OTUD1

 

Full name: OTU deubiquitinase 1 Alias Symbol: DUBA7
Type: protein-coding gene Cytoband: 10p12.2
Entrez ID: 220213 HGNC ID: HGNC:27346 Ensembl Gene: ENSG00000165312 OMIM ID: 612022
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of OTUD1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 OTUD1 220213 226140_s_at 0.0396 0.9733
GSE26886 OTUD1 220213 226140_s_at -0.1955 0.5738
GSE45670 OTUD1 220213 226140_s_at 0.1621 0.4806
GSE53622 OTUD1 220213 55367 -0.0577 0.5891
GSE53624 OTUD1 220213 55367 -0.0920 0.4120
GSE63941 OTUD1 220213 226140_s_at 0.2718 0.7296
GSE77861 OTUD1 220213 226140_s_at 0.1357 0.5372
GSE97050 OTUD1 220213 A_32_P60459 0.0392 0.9191
SRP007169 OTUD1 220213 RNAseq -1.2127 0.0175
SRP008496 OTUD1 220213 RNAseq -1.2538 0.0000
SRP064894 OTUD1 220213 RNAseq 0.0739 0.6890
SRP133303 OTUD1 220213 RNAseq 0.1308 0.3641
SRP159526 OTUD1 220213 RNAseq -0.1747 0.6065
SRP193095 OTUD1 220213 RNAseq -0.4836 0.0133
SRP219564 OTUD1 220213 RNAseq -0.2631 0.3263
TCGA OTUD1 220213 RNAseq -0.1797 0.0314

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by OTUD1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of OTUD1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 OTUD1 220213 5 7 18
GSE20123 OTUD1 220213 5 6 19
GSE43470 OTUD1 220213 4 4 35
GSE46452 OTUD1 220213 1 14 44
GSE47630 OTUD1 220213 5 15 20
GSE54993 OTUD1 220213 9 0 61
GSE54994 OTUD1 220213 3 9 41
GSE60625 OTUD1 220213 0 0 11
GSE74703 OTUD1 220213 3 2 31
GSE74704 OTUD1 220213 0 5 15
TCGA OTUD1 220213 18 26 52

Total number of gains: 53; Total number of losses: 88; Total Number of normals: 347.  

 

Somatic mutations of OTUD1:

 

Generating mutation plots.

 

Highly correlated genes for OTUD1:

 

Showing all 5 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
OTUD1PLEKHA10.59562303
OTUD1TMEM1270.589436303
OTUD1OPA10.573092303
OTUD1FBXW20.538508403
OTUD1NAPG0.525022403

For details and further investigation, click here