| Full name: transmembrane protein 127 | Alias Symbol: FLJ20507|FLJ22257 | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 55654 | HGNC ID: HGNC:26038 | Ensembl Gene: ENSG00000135956 | OMIM ID: 613403 |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM127:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM127 | 55654 | 219460_s_at | 0.0088 | 0.9864 | |
| GSE20347 | TMEM127 | 55654 | 219460_s_at | -0.3155 | 0.0051 | |
| GSE23400 | TMEM127 | 55654 | 219460_s_at | -0.1838 | 0.0003 | |
| GSE26886 | TMEM127 | 55654 | 219460_s_at | -0.2758 | 0.3009 | |
| GSE29001 | TMEM127 | 55654 | 219460_s_at | -0.4739 | 0.0650 | |
| GSE38129 | TMEM127 | 55654 | 219460_s_at | -0.2890 | 0.0023 | |
| GSE45670 | TMEM127 | 55654 | 219460_s_at | -0.2220 | 0.0995 | |
| GSE53622 | TMEM127 | 55654 | 127445 | -0.6717 | 0.0000 | |
| GSE53624 | TMEM127 | 55654 | 127445 | -0.5845 | 0.0000 | |
| GSE63941 | TMEM127 | 55654 | 219460_s_at | -1.0683 | 0.0288 | |
| GSE77861 | TMEM127 | 55654 | 219460_s_at | -0.0944 | 0.6005 | |
| GSE97050 | TMEM127 | 55654 | A_24_P80181 | -0.3036 | 0.3511 | |
| SRP007169 | TMEM127 | 55654 | RNAseq | -1.6248 | 0.0001 | |
| SRP008496 | TMEM127 | 55654 | RNAseq | -1.5308 | 0.0000 | |
| SRP064894 | TMEM127 | 55654 | RNAseq | -0.5698 | 0.0000 | |
| SRP133303 | TMEM127 | 55654 | RNAseq | -0.2491 | 0.0303 | |
| SRP159526 | TMEM127 | 55654 | RNAseq | -0.3108 | 0.2102 | |
| SRP193095 | TMEM127 | 55654 | RNAseq | -0.7505 | 0.0000 | |
| SRP219564 | TMEM127 | 55654 | RNAseq | -0.4640 | 0.0844 | |
| TCGA | TMEM127 | 55654 | RNAseq | -0.0396 | 0.3341 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by TMEM127 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM127:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM127 | 55654 | 6 | 2 | 22 | |
| GSE20123 | TMEM127 | 55654 | 6 | 2 | 22 | |
| GSE43470 | TMEM127 | 55654 | 2 | 3 | 38 | |
| GSE46452 | TMEM127 | 55654 | 2 | 3 | 54 | |
| GSE47630 | TMEM127 | 55654 | 7 | 0 | 33 | |
| GSE54993 | TMEM127 | 55654 | 0 | 6 | 64 | |
| GSE54994 | TMEM127 | 55654 | 11 | 0 | 42 | |
| GSE60625 | TMEM127 | 55654 | 0 | 3 | 8 | |
| GSE74703 | TMEM127 | 55654 | 2 | 2 | 32 | |
| GSE74704 | TMEM127 | 55654 | 4 | 1 | 15 | |
| TCGA | TMEM127 | 55654 | 35 | 3 | 58 |
Total number of gains: 75; Total number of losses: 25; Total Number of normals: 388.
Somatic mutations of TMEM127:
Generating mutation plots.
Highly correlated genes for TMEM127:
Showing top 20/783 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM127 | SYPL1 | 0.749279 | 3 | 0 | 3 |
| TMEM127 | DDI2 | 0.717616 | 3 | 0 | 3 |
| TMEM127 | CDKL5 | 0.715772 | 4 | 0 | 4 |
| TMEM127 | KCNK6 | 0.706875 | 3 | 0 | 3 |
| TMEM127 | ZDHHC21 | 0.702081 | 4 | 0 | 4 |
| TMEM127 | SAMD5 | 0.694874 | 4 | 0 | 4 |
| TMEM127 | CHCHD1 | 0.693779 | 3 | 0 | 3 |
| TMEM127 | ARMCX6 | 0.688478 | 3 | 0 | 3 |
| TMEM127 | NUAK2 | 0.686057 | 3 | 0 | 3 |
| TMEM127 | ZNF578 | 0.685311 | 3 | 0 | 3 |
| TMEM127 | CYSRT1 | 0.683565 | 3 | 0 | 3 |
| TMEM127 | RCAN3 | 0.681741 | 3 | 0 | 3 |
| TMEM127 | VPS37B | 0.681564 | 9 | 0 | 9 |
| TMEM127 | OTUD7B | 0.680319 | 3 | 0 | 3 |
| TMEM127 | YAF2 | 0.679887 | 3 | 0 | 3 |
| TMEM127 | ZNF394 | 0.678563 | 3 | 0 | 3 |
| TMEM127 | DBNL | 0.675418 | 3 | 0 | 3 |
| TMEM127 | SLC46A2 | 0.670798 | 5 | 0 | 4 |
| TMEM127 | STRADB | 0.665463 | 5 | 0 | 4 |
| TMEM127 | PPP2CA | 0.661506 | 3 | 0 | 3 |
For details and further investigation, click here
