| Full name: F-box and WD repeat domain containing 2 | Alias Symbol: FBW2|Md6|Fwd2 | ||
| Type: protein-coding gene | Cytoband: 9q33.2 | ||
| Entrez ID: 26190 | HGNC ID: HGNC:13608 | Ensembl Gene: ENSG00000119402 | OMIM ID: 609071 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXW2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXW2 | 26190 | 209630_s_at | -0.1121 | 0.7856 | |
| GSE20347 | FBXW2 | 26190 | 209630_s_at | -0.6957 | 0.0002 | |
| GSE23400 | FBXW2 | 26190 | 209630_s_at | 0.2178 | 0.0586 | |
| GSE26886 | FBXW2 | 26190 | 209630_s_at | -0.6193 | 0.0209 | |
| GSE29001 | FBXW2 | 26190 | 209630_s_at | 0.2022 | 0.4024 | |
| GSE38129 | FBXW2 | 26190 | 209630_s_at | -0.3995 | 0.0089 | |
| GSE45670 | FBXW2 | 26190 | 209630_s_at | -0.1836 | 0.3071 | |
| GSE53622 | FBXW2 | 26190 | 102317 | 0.0376 | 0.5662 | |
| GSE53624 | FBXW2 | 26190 | 102317 | 0.1768 | 0.0671 | |
| GSE63941 | FBXW2 | 26190 | 209630_s_at | 0.1043 | 0.8410 | |
| GSE77861 | FBXW2 | 26190 | 209630_s_at | -0.1050 | 0.6940 | |
| GSE97050 | FBXW2 | 26190 | A_23_P254648 | 0.0487 | 0.8218 | |
| SRP007169 | FBXW2 | 26190 | RNAseq | 0.4112 | 0.3255 | |
| SRP008496 | FBXW2 | 26190 | RNAseq | 0.5370 | 0.0139 | |
| SRP064894 | FBXW2 | 26190 | RNAseq | 0.0763 | 0.6057 | |
| SRP133303 | FBXW2 | 26190 | RNAseq | 0.4576 | 0.1209 | |
| SRP159526 | FBXW2 | 26190 | RNAseq | -0.0271 | 0.9048 | |
| SRP193095 | FBXW2 | 26190 | RNAseq | -0.0982 | 0.2097 | |
| SRP219564 | FBXW2 | 26190 | RNAseq | -0.1145 | 0.5989 | |
| TCGA | FBXW2 | 26190 | RNAseq | -0.0936 | 0.0394 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FBXW2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXW2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXW2 | 26190 | 3 | 7 | 20 | |
| GSE20123 | FBXW2 | 26190 | 3 | 7 | 20 | |
| GSE43470 | FBXW2 | 26190 | 5 | 4 | 34 | |
| GSE46452 | FBXW2 | 26190 | 6 | 13 | 40 | |
| GSE47630 | FBXW2 | 26190 | 3 | 16 | 21 | |
| GSE54993 | FBXW2 | 26190 | 3 | 3 | 64 | |
| GSE54994 | FBXW2 | 26190 | 9 | 10 | 34 | |
| GSE60625 | FBXW2 | 26190 | 0 | 0 | 11 | |
| GSE74703 | FBXW2 | 26190 | 5 | 3 | 28 | |
| GSE74704 | FBXW2 | 26190 | 2 | 5 | 13 | |
| TCGA | FBXW2 | 26190 | 27 | 25 | 44 |
Total number of gains: 66; Total number of losses: 93; Total Number of normals: 329.
Somatic mutations of FBXW2:
Generating mutation plots.
Highly correlated genes for FBXW2:
Showing top 20/526 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXW2 | EXOC8 | 0.800202 | 3 | 0 | 3 |
| FBXW2 | NAPG | 0.790596 | 3 | 0 | 3 |
| FBXW2 | VPS29 | 0.78219 | 3 | 0 | 3 |
| FBXW2 | EIF2S2 | 0.775101 | 3 | 0 | 3 |
| FBXW2 | CNOT4 | 0.772429 | 3 | 0 | 3 |
| FBXW2 | WDR77 | 0.760823 | 3 | 0 | 3 |
| FBXW2 | SLC35B3 | 0.748744 | 3 | 0 | 3 |
| FBXW2 | CHCHD4 | 0.741761 | 3 | 0 | 3 |
| FBXW2 | CCNYL1 | 0.74145 | 3 | 0 | 3 |
| FBXW2 | HEATR5B | 0.737225 | 3 | 0 | 3 |
| FBXW2 | WDR26 | 0.731914 | 3 | 0 | 3 |
| FBXW2 | COX15 | 0.731309 | 4 | 0 | 4 |
| FBXW2 | ZMAT3 | 0.728112 | 3 | 0 | 3 |
| FBXW2 | IMPDH2 | 0.719995 | 3 | 0 | 3 |
| FBXW2 | TXNIP | 0.718825 | 3 | 0 | 3 |
| FBXW2 | PLA2G12A | 0.718176 | 3 | 0 | 3 |
| FBXW2 | FAM98A | 0.717078 | 3 | 0 | 3 |
| FBXW2 | RAB18 | 0.715429 | 3 | 0 | 3 |
| FBXW2 | WDR37 | 0.715316 | 4 | 0 | 3 |
| FBXW2 | SIAE | 0.713786 | 3 | 0 | 3 |
For details and further investigation, click here
