| Full name: pleckstrin homology domain containing A1 | Alias Symbol: TAPP1 | ||
| Type: protein-coding gene | Cytoband: 10q26.13 | ||
| Entrez ID: 59338 | HGNC ID: HGNC:14335 | Ensembl Gene: ENSG00000107679 | OMIM ID: 607772 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHA1 | 59338 | 226247_at | -0.1904 | 0.5947 | |
| GSE20347 | PLEKHA1 | 59338 | 219024_at | 0.2524 | 0.2124 | |
| GSE23400 | PLEKHA1 | 59338 | 219024_at | 0.1972 | 0.0984 | |
| GSE26886 | PLEKHA1 | 59338 | 226247_at | 0.6720 | 0.0020 | |
| GSE29001 | PLEKHA1 | 59338 | 219024_at | -0.0874 | 0.8905 | |
| GSE38129 | PLEKHA1 | 59338 | 219024_at | 0.3440 | 0.1363 | |
| GSE45670 | PLEKHA1 | 59338 | 226247_at | 0.0503 | 0.7776 | |
| GSE53622 | PLEKHA1 | 59338 | 59689 | -0.0713 | 0.3777 | |
| GSE53624 | PLEKHA1 | 59338 | 59689 | 0.0835 | 0.3083 | |
| GSE63941 | PLEKHA1 | 59338 | 226247_at | 0.0684 | 0.9076 | |
| GSE77861 | PLEKHA1 | 59338 | 226247_at | 0.4299 | 0.1411 | |
| GSE97050 | PLEKHA1 | 59338 | A_23_P115792 | -0.0387 | 0.8859 | |
| SRP007169 | PLEKHA1 | 59338 | RNAseq | 0.3490 | 0.4581 | |
| SRP008496 | PLEKHA1 | 59338 | RNAseq | 0.3330 | 0.3025 | |
| SRP064894 | PLEKHA1 | 59338 | RNAseq | -0.1318 | 0.6369 | |
| SRP133303 | PLEKHA1 | 59338 | RNAseq | 0.3983 | 0.0256 | |
| SRP159526 | PLEKHA1 | 59338 | RNAseq | 0.2572 | 0.6279 | |
| SRP193095 | PLEKHA1 | 59338 | RNAseq | 0.0360 | 0.7748 | |
| SRP219564 | PLEKHA1 | 59338 | RNAseq | -0.3851 | 0.1708 | |
| TCGA | PLEKHA1 | 59338 | RNAseq | 0.0359 | 0.5184 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PLEKHA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHA1 | 59338 | 4 | 6 | 20 | |
| GSE20123 | PLEKHA1 | 59338 | 3 | 6 | 21 | |
| GSE43470 | PLEKHA1 | 59338 | 0 | 9 | 34 | |
| GSE46452 | PLEKHA1 | 59338 | 0 | 11 | 48 | |
| GSE47630 | PLEKHA1 | 59338 | 2 | 14 | 24 | |
| GSE54993 | PLEKHA1 | 59338 | 8 | 1 | 61 | |
| GSE54994 | PLEKHA1 | 59338 | 1 | 9 | 43 | |
| GSE60625 | PLEKHA1 | 59338 | 0 | 0 | 11 | |
| GSE74703 | PLEKHA1 | 59338 | 0 | 6 | 30 | |
| GSE74704 | PLEKHA1 | 59338 | 2 | 2 | 16 | |
| TCGA | PLEKHA1 | 59338 | 4 | 28 | 64 |
Total number of gains: 24; Total number of losses: 92; Total Number of normals: 372.
Somatic mutations of PLEKHA1:
Generating mutation plots.
Highly correlated genes for PLEKHA1:
Showing top 20/34 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHA1 | TP53BP1 | 0.723444 | 3 | 0 | 3 |
| PLEKHA1 | ZNF559 | 0.701042 | 4 | 0 | 4 |
| PLEKHA1 | ZNF697 | 0.699326 | 3 | 0 | 3 |
| PLEKHA1 | ZNF678 | 0.685874 | 3 | 0 | 3 |
| PLEKHA1 | PHF10 | 0.685358 | 3 | 0 | 3 |
| PLEKHA1 | HOXC9 | 0.67441 | 3 | 0 | 3 |
| PLEKHA1 | MLF1 | 0.66778 | 3 | 0 | 3 |
| PLEKHA1 | POC1B | 0.667667 | 4 | 0 | 3 |
| PLEKHA1 | SLCO1A2 | 0.666717 | 3 | 0 | 3 |
| PLEKHA1 | TCHH | 0.666478 | 3 | 0 | 3 |
| PLEKHA1 | C19orf53 | 0.64527 | 3 | 0 | 3 |
| PLEKHA1 | LRRC57 | 0.63564 | 4 | 0 | 3 |
| PLEKHA1 | LAMA5 | 0.635219 | 4 | 0 | 3 |
| PLEKHA1 | EFR3A | 0.62806 | 3 | 0 | 3 |
| PLEKHA1 | TTC32 | 0.620644 | 4 | 0 | 3 |
| PLEKHA1 | OTUD1 | 0.59562 | 3 | 0 | 3 |
| PLEKHA1 | FUT10 | 0.595374 | 4 | 0 | 3 |
| PLEKHA1 | TAF4 | 0.579344 | 4 | 0 | 3 |
| PLEKHA1 | CCDC113 | 0.572903 | 3 | 0 | 3 |
| PLEKHA1 | FOXP2 | 0.570565 | 3 | 0 | 3 |
For details and further investigation, click here
