CNBD1

 

Full name: cyclic nucleotide binding domain containing 1 Alias Symbol: FLJ35802
Type: protein-coding gene Cytoband: 8q21.3
Entrez ID: 168975 HGNC ID: HGNC:26663 Ensembl Gene: ENSG00000176571 OMIM ID: 
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CNBD1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CNBD1 168975 1552587_at 0.0821 0.7190
GSE26886 CNBD1 168975 1552587_at -0.0334 0.8046
GSE45670 CNBD1 168975 1552587_at 0.0957 0.3050
GSE53622 CNBD1 168975 5463 0.1465 0.3976
GSE53624 CNBD1 168975 5463 0.1430 0.1674
GSE63941 CNBD1 168975 1552588_a_at 0.0465 0.7818
GSE77861 CNBD1 168975 1552587_at -0.0133 0.9170
TCGA CNBD1 168975 RNAseq 1.3624 0.5126

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CNBD1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CNBD1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CNBD1 168975 14 1 15
GSE20123 CNBD1 168975 16 1 13
GSE43470 CNBD1 168975 19 1 23
GSE46452 CNBD1 168975 21 0 38
GSE47630 CNBD1 168975 23 0 17
GSE54993 CNBD1 168975 0 20 50
GSE54994 CNBD1 168975 33 1 19
GSE60625 CNBD1 168975 0 4 7
GSE74703 CNBD1 168975 16 1 19
GSE74704 CNBD1 168975 10 0 10
TCGA CNBD1 168975 53 2 41

Total number of gains: 205; Total number of losses: 31; Total Number of normals: 252.  

 

Somatic mutations of CNBD1:

 

Generating mutation plots.

 

Highly correlated genes for CNBD1:

 

Showing all 5 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CNBD1HGF0.585858303
CNBD1NXNL10.583846303
CNBD1LINC002610.571288303
CNBD1BEST10.55211303
CNBD1ZNF1350.501059403

For details and further investigation, click here