| Full name: hepatocyte growth factor | Alias Symbol: SF|F-TCF|HGFB|HPTA | ||
| Type: protein-coding gene | Cytoband: 7q21.11 | ||
| Entrez ID: 3082 | HGNC ID: HGNC:4893 | Ensembl Gene: ENSG00000019991 | OMIM ID: 142409 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
HGF involved pathways:
Expression of HGF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HGF | 3082 | 209961_s_at | 0.1130 | 0.6008 | |
| GSE20347 | HGF | 3082 | 209961_s_at | -0.0264 | 0.8160 | |
| GSE23400 | HGF | 3082 | 209961_s_at | -0.0416 | 0.3555 | |
| GSE26886 | HGF | 3082 | 210998_s_at | 0.0437 | 0.7116 | |
| GSE29001 | HGF | 3082 | 209961_s_at | -0.0364 | 0.8151 | |
| GSE38129 | HGF | 3082 | 209961_s_at | -0.0539 | 0.4915 | |
| GSE45670 | HGF | 3082 | 209961_s_at | 0.1216 | 0.1845 | |
| GSE53622 | HGF | 3082 | 26022 | -0.7149 | 0.0000 | |
| GSE53624 | HGF | 3082 | 26022 | -0.2203 | 0.2345 | |
| GSE63941 | HGF | 3082 | 209961_s_at | -2.5652 | 0.0000 | |
| GSE77861 | HGF | 3082 | 209961_s_at | -0.0619 | 0.5059 | |
| GSE97050 | HGF | 3082 | A_33_P3276713 | 0.1187 | 0.8053 | |
| SRP007169 | HGF | 3082 | RNAseq | 2.2897 | 0.0168 | |
| SRP064894 | HGF | 3082 | RNAseq | 0.4173 | 0.3053 | |
| SRP133303 | HGF | 3082 | RNAseq | -0.4213 | 0.2689 | |
| SRP159526 | HGF | 3082 | RNAseq | 0.8222 | 0.0762 | |
| SRP193095 | HGF | 3082 | RNAseq | 1.2620 | 0.0024 | |
| SRP219564 | HGF | 3082 | RNAseq | 0.7329 | 0.4087 | |
| TCGA | HGF | 3082 | RNAseq | -0.6044 | 0.0829 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by HGF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HGF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HGF | 3082 | 12 | 1 | 17 | |
| GSE20123 | HGF | 3082 | 12 | 1 | 17 | |
| GSE43470 | HGF | 3082 | 4 | 1 | 38 | |
| GSE46452 | HGF | 3082 | 11 | 0 | 48 | |
| GSE47630 | HGF | 3082 | 7 | 3 | 30 | |
| GSE54993 | HGF | 3082 | 1 | 7 | 62 | |
| GSE54994 | HGF | 3082 | 16 | 3 | 34 | |
| GSE60625 | HGF | 3082 | 0 | 0 | 11 | |
| GSE74703 | HGF | 3082 | 3 | 1 | 32 | |
| GSE74704 | HGF | 3082 | 7 | 1 | 12 | |
| TCGA | HGF | 3082 | 46 | 5 | 45 |
Total number of gains: 119; Total number of losses: 23; Total Number of normals: 346.
Somatic mutations of HGF:
Generating mutation plots.
Highly correlated genes for HGF:
Showing top 20/727 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HGF | SLC16A4 | 0.841137 | 4 | 0 | 4 |
| HGF | RHOJ | 0.814102 | 3 | 0 | 3 |
| HGF | GIMAP5 | 0.807194 | 3 | 0 | 3 |
| HGF | PTGER2 | 0.80146 | 4 | 0 | 4 |
| HGF | ECSCR | 0.783413 | 3 | 0 | 3 |
| HGF | TNFSF12 | 0.780671 | 3 | 0 | 3 |
| HGF | LRRK2 | 0.780548 | 3 | 0 | 3 |
| HGF | PDGFRB | 0.776837 | 3 | 0 | 3 |
| HGF | A1BG | 0.772582 | 3 | 0 | 3 |
| HGF | TBC1D19 | 0.766379 | 3 | 0 | 3 |
| HGF | RSPO3 | 0.762327 | 4 | 0 | 4 |
| HGF | STX11 | 0.759612 | 3 | 0 | 3 |
| HGF | TRAFD1 | 0.75939 | 3 | 0 | 3 |
| HGF | FAM124A | 0.755774 | 3 | 0 | 3 |
| HGF | COLEC12 | 0.751827 | 4 | 0 | 4 |
| HGF | CSF1R | 0.750085 | 4 | 0 | 4 |
| HGF | ZNF358 | 0.742746 | 3 | 0 | 3 |
| HGF | NAP1L3 | 0.739862 | 3 | 0 | 3 |
| HGF | ARHGAP31 | 0.73353 | 5 | 0 | 5 |
| HGF | LRFN5 | 0.733493 | 3 | 0 | 3 |
For details and further investigation, click here
