| Full name: bestrophin 1 | Alias Symbol: BMD|BEST|RP50 | ||
| Type: protein-coding gene | Cytoband: 11q12.3 | ||
| Entrez ID: 7439 | HGNC ID: HGNC:12703 | Ensembl Gene: ENSG00000167995 | OMIM ID: 607854 |
| Drug and gene relationship at DGIdb | |||
Expression of BEST1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BEST1 | 7439 | 1554442_at | 0.2219 | 0.4374 | |
| GSE20347 | BEST1 | 7439 | 207671_s_at | 0.0403 | 0.6985 | |
| GSE23400 | BEST1 | 7439 | 207671_s_at | -0.1162 | 0.0022 | |
| GSE26886 | BEST1 | 7439 | 1554442_at | 0.0039 | 0.9823 | |
| GSE29001 | BEST1 | 7439 | 207671_s_at | -0.1776 | 0.2213 | |
| GSE38129 | BEST1 | 7439 | 207671_s_at | -0.1641 | 0.1690 | |
| GSE45670 | BEST1 | 7439 | 1554442_at | 0.0767 | 0.4640 | |
| GSE53622 | BEST1 | 7439 | 42276 | 0.2751 | 0.0130 | |
| GSE53624 | BEST1 | 7439 | 42276 | 0.3950 | 0.0000 | |
| GSE63941 | BEST1 | 7439 | 1554442_at | 0.2605 | 0.3775 | |
| GSE77861 | BEST1 | 7439 | 1554442_at | 0.0716 | 0.6947 | |
| GSE97050 | BEST1 | 7439 | A_23_P104996 | 0.2895 | 0.3485 | |
| SRP007169 | BEST1 | 7439 | RNAseq | -1.3750 | 0.0066 | |
| SRP064894 | BEST1 | 7439 | RNAseq | -1.1568 | 0.0003 | |
| SRP133303 | BEST1 | 7439 | RNAseq | -0.1421 | 0.5775 | |
| SRP159526 | BEST1 | 7439 | RNAseq | 0.2240 | 0.5193 | |
| SRP193095 | BEST1 | 7439 | RNAseq | -0.1774 | 0.4675 | |
| SRP219564 | BEST1 | 7439 | RNAseq | -0.1621 | 0.7098 | |
| TCGA | BEST1 | 7439 | RNAseq | -0.2739 | 0.0694 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by BEST1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BEST1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BEST1 | 7439 | 5 | 5 | 20 | |
| GSE20123 | BEST1 | 7439 | 5 | 5 | 20 | |
| GSE43470 | BEST1 | 7439 | 2 | 6 | 35 | |
| GSE46452 | BEST1 | 7439 | 8 | 4 | 47 | |
| GSE47630 | BEST1 | 7439 | 3 | 7 | 30 | |
| GSE54993 | BEST1 | 7439 | 3 | 0 | 67 | |
| GSE54994 | BEST1 | 7439 | 4 | 5 | 44 | |
| GSE60625 | BEST1 | 7439 | 0 | 3 | 8 | |
| GSE74703 | BEST1 | 7439 | 2 | 3 | 31 | |
| GSE74704 | BEST1 | 7439 | 4 | 3 | 13 | |
| TCGA | BEST1 | 7439 | 14 | 10 | 72 |
Total number of gains: 50; Total number of losses: 51; Total Number of normals: 387.
Somatic mutations of BEST1:
Generating mutation plots.
Highly correlated genes for BEST1:
Showing top 20/665 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BEST1 | WDR11-AS1 | 0.78838 | 3 | 0 | 3 |
| BEST1 | TRIM47 | 0.774684 | 3 | 0 | 3 |
| BEST1 | GRAMD1A | 0.719754 | 4 | 0 | 4 |
| BEST1 | C11orf68 | 0.713187 | 3 | 0 | 3 |
| BEST1 | RBM14 | 0.699823 | 3 | 0 | 3 |
| BEST1 | C1orf43 | 0.696913 | 3 | 0 | 3 |
| BEST1 | EXOC3L1 | 0.695816 | 4 | 0 | 4 |
| BEST1 | NOVA2 | 0.692854 | 4 | 0 | 4 |
| BEST1 | STAT5A | 0.690223 | 3 | 0 | 3 |
| BEST1 | DUX1 | 0.68868 | 4 | 0 | 4 |
| BEST1 | CDO1 | 0.688187 | 3 | 0 | 3 |
| BEST1 | PI4KB | 0.687952 | 3 | 0 | 3 |
| BEST1 | VWA3A | 0.687353 | 4 | 0 | 4 |
| BEST1 | CDC42EP4 | 0.677913 | 3 | 0 | 3 |
| BEST1 | UBXN11 | 0.677894 | 4 | 0 | 4 |
| BEST1 | SHOX | 0.67584 | 3 | 0 | 3 |
| BEST1 | ZFP92 | 0.675747 | 5 | 0 | 4 |
| BEST1 | FAM170B-AS1 | 0.675555 | 3 | 0 | 3 |
| BEST1 | FCGR2C | 0.673497 | 3 | 0 | 3 |
| BEST1 | KCNIP2-AS1 | 0.671607 | 4 | 0 | 3 |
For details and further investigation, click here
