ITGB6

 

Full name: integrin subunit beta 6 Alias Symbol: 
Type: protein-coding gene Cytoband: 2q24.2
Entrez ID: 3694 HGNC ID: HGNC:6161 Ensembl Gene: ENSG00000115221 OMIM ID: 147558
Drug and gene relationship at DGIdb

 

ITGB6 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04810Regulation of actin cytoskeleton

 

Expression of ITGB6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 ITGB6 3694 106301 1.2764 0.0000
GSE53624 ITGB6 3694 25444 0.6746 0.0000
GSE97050 ITGB6 3694 A_23_P154217 2.8650 0.1711
SRP007169 ITGB6 3694 RNAseq 0.9970 0.0061
SRP008496 ITGB6 3694 RNAseq 1.0586 0.0012
SRP064894 ITGB6 3694 RNAseq 1.3672 0.0035
SRP133303 ITGB6 3694 RNAseq 2.1174 0.0000
SRP159526 ITGB6 3694 RNAseq -0.7421 0.1090
SRP193095 ITGB6 3694 RNAseq 0.6347 0.0213
SRP219564 ITGB6 3694 RNAseq 0.9077 0.5175
TCGA ITGB6 3694 RNAseq 0.4333 0.0434

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by ITGB6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ITGB6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ITGB6 3694 5 1 24
GSE20123 ITGB6 3694 5 1 24
GSE43470 ITGB6 3694 4 1 38
GSE46452 ITGB6 3694 1 4 54
GSE47630 ITGB6 3694 5 3 32
GSE54993 ITGB6 3694 0 4 66
GSE54994 ITGB6 3694 11 2 40
GSE60625 ITGB6 3694 0 3 8
GSE74703 ITGB6 3694 3 1 32
GSE74704 ITGB6 3694 3 0 17
TCGA ITGB6 3694 23 10 63

Total number of gains: 60; Total number of losses: 30; Total Number of normals: 398.  

 

Somatic mutations of ITGB6:

 

Generating mutation plots.

 

Highly correlated genes for ITGB6:

 

Showing all 5 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ITGB6TNS40.685387303
ITGB6LAMB30.681258303
ITGB6COL17A10.594169303
ITGB6IL1RAP0.591687403
ITGB6PLEK20.573971403

For details and further investigation, click here