| Full name: interleukin 1 receptor accessory protein | Alias Symbol: IL-1RAcP|IL1R3|C3orf13 | ||
| Type: protein-coding gene | Cytoband: 3q28 | ||
| Entrez ID: 3556 | HGNC ID: HGNC:5995 | Ensembl Gene: ENSG00000196083 | OMIM ID: 602626 |
| Drug and gene relationship at DGIdb | |||
IL1RAP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of IL1RAP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL1RAP | 3556 | 205227_at | 0.4515 | 0.7192 | |
| GSE20347 | IL1RAP | 3556 | 205227_at | -0.0448 | 0.7661 | |
| GSE23400 | IL1RAP | 3556 | 205227_at | 0.1783 | 0.0057 | |
| GSE26886 | IL1RAP | 3556 | 205227_at | -0.2689 | 0.3921 | |
| GSE29001 | IL1RAP | 3556 | 205227_at | -0.1485 | 0.5571 | |
| GSE38129 | IL1RAP | 3556 | 205227_at | 0.5564 | 0.0417 | |
| GSE45670 | IL1RAP | 3556 | 205227_at | 0.6045 | 0.0190 | |
| GSE53622 | IL1RAP | 3556 | 107491 | 0.7436 | 0.0000 | |
| GSE53624 | IL1RAP | 3556 | 94498 | 0.3491 | 0.0015 | |
| GSE63941 | IL1RAP | 3556 | 205227_at | 1.5951 | 0.0241 | |
| GSE77861 | IL1RAP | 3556 | 205227_at | 0.0189 | 0.9645 | |
| GSE97050 | IL1RAP | 3556 | A_23_P170857 | 1.2657 | 0.1356 | |
| SRP007169 | IL1RAP | 3556 | RNAseq | -0.3072 | 0.4455 | |
| SRP008496 | IL1RAP | 3556 | RNAseq | 0.4770 | 0.2037 | |
| SRP064894 | IL1RAP | 3556 | RNAseq | 0.4052 | 0.2278 | |
| SRP133303 | IL1RAP | 3556 | RNAseq | 1.0753 | 0.0005 | |
| SRP159526 | IL1RAP | 3556 | RNAseq | 0.3052 | 0.4737 | |
| SRP193095 | IL1RAP | 3556 | RNAseq | 0.9225 | 0.0011 | |
| SRP219564 | IL1RAP | 3556 | RNAseq | 0.5400 | 0.5396 | |
| TCGA | IL1RAP | 3556 | RNAseq | 0.6211 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by IL1RAP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL1RAP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL1RAP | 3556 | 25 | 0 | 5 | |
| GSE20123 | IL1RAP | 3556 | 25 | 0 | 5 | |
| GSE43470 | IL1RAP | 3556 | 25 | 0 | 18 | |
| GSE46452 | IL1RAP | 3556 | 19 | 1 | 39 | |
| GSE47630 | IL1RAP | 3556 | 27 | 2 | 11 | |
| GSE54993 | IL1RAP | 3556 | 1 | 19 | 50 | |
| GSE54994 | IL1RAP | 3556 | 39 | 0 | 14 | |
| GSE60625 | IL1RAP | 3556 | 0 | 6 | 5 | |
| GSE74703 | IL1RAP | 3556 | 20 | 0 | 16 | |
| GSE74704 | IL1RAP | 3556 | 17 | 0 | 3 | |
| TCGA | IL1RAP | 3556 | 76 | 0 | 20 |
Total number of gains: 274; Total number of losses: 28; Total Number of normals: 186.
Somatic mutations of IL1RAP:
Generating mutation plots.
Highly correlated genes for IL1RAP:
Showing top 20/411 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL1RAP | PLS1 | 0.713855 | 3 | 0 | 3 |
| IL1RAP | SPAG1 | 0.706867 | 4 | 0 | 3 |
| IL1RAP | DCLRE1B | 0.688699 | 3 | 0 | 3 |
| IL1RAP | ARL4C | 0.683099 | 3 | 0 | 3 |
| IL1RAP | ADAMTS14 | 0.677159 | 3 | 0 | 3 |
| IL1RAP | ACER3 | 0.67712 | 4 | 0 | 3 |
| IL1RAP | ZWILCH | 0.676457 | 5 | 0 | 4 |
| IL1RAP | SORD | 0.675336 | 4 | 0 | 3 |
| IL1RAP | PSMG3 | 0.672368 | 4 | 0 | 4 |
| IL1RAP | TLCD1 | 0.670264 | 3 | 0 | 3 |
| IL1RAP | RCC1 | 0.669201 | 5 | 0 | 4 |
| IL1RAP | OSBPL8 | 0.668971 | 3 | 0 | 3 |
| IL1RAP | ZDHHC12 | 0.667579 | 4 | 0 | 4 |
| IL1RAP | FBXO11 | 0.664354 | 4 | 0 | 3 |
| IL1RAP | CFI | 0.664151 | 3 | 0 | 3 |
| IL1RAP | RPA2 | 0.662903 | 3 | 0 | 3 |
| IL1RAP | ELOVL7 | 0.662211 | 3 | 0 | 3 |
| IL1RAP | NPRL3 | 0.661284 | 3 | 0 | 3 |
| IL1RAP | SLC38A9 | 0.659578 | 3 | 0 | 3 |
| IL1RAP | WNT10A | 0.656938 | 4 | 0 | 3 |
For details and further investigation, click here
