| Full name: tensin 4 | Alias Symbol: CTEN | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 84951 | HGNC ID: HGNC:24352 | Ensembl Gene: ENSG00000131746 | OMIM ID: 608385 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TNS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNS4 | 84951 | 230398_at | 1.4376 | 0.0535 | |
| GSE20347 | TNS4 | 84951 | 222265_at | 0.3811 | 0.0051 | |
| GSE23400 | TNS4 | 84951 | 222265_at | 0.2368 | 0.0009 | |
| GSE26886 | TNS4 | 84951 | 230398_at | 1.1276 | 0.0000 | |
| GSE29001 | TNS4 | 84951 | 222265_at | 0.1022 | 0.5905 | |
| GSE38129 | TNS4 | 84951 | 222265_at | 0.3478 | 0.0034 | |
| GSE45670 | TNS4 | 84951 | 230398_at | 0.9163 | 0.0019 | |
| GSE53622 | TNS4 | 84951 | 99531 | 1.0388 | 0.0000 | |
| GSE53624 | TNS4 | 84951 | 99531 | 0.8877 | 0.0000 | |
| GSE63941 | TNS4 | 84951 | 230398_at | 2.1152 | 0.0037 | |
| GSE77861 | TNS4 | 84951 | 230398_at | 0.9722 | 0.0070 | |
| GSE97050 | TNS4 | 84951 | A_23_P207850 | 1.5425 | 0.1239 | |
| SRP007169 | TNS4 | 84951 | RNAseq | 2.3716 | 0.0000 | |
| SRP008496 | TNS4 | 84951 | RNAseq | 1.6981 | 0.0000 | |
| SRP064894 | TNS4 | 84951 | RNAseq | 0.9370 | 0.0439 | |
| SRP133303 | TNS4 | 84951 | RNAseq | 1.6478 | 0.0000 | |
| SRP159526 | TNS4 | 84951 | RNAseq | 0.2945 | 0.5088 | |
| SRP193095 | TNS4 | 84951 | RNAseq | 1.5724 | 0.0000 | |
| SRP219564 | TNS4 | 84951 | RNAseq | 1.8705 | 0.0908 | |
| TCGA | TNS4 | 84951 | RNAseq | 1.4178 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by TNS4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNS4 | 84951 | 7 | 1 | 22 | |
| GSE20123 | TNS4 | 84951 | 7 | 1 | 22 | |
| GSE43470 | TNS4 | 84951 | 1 | 2 | 40 | |
| GSE46452 | TNS4 | 84951 | 34 | 0 | 25 | |
| GSE47630 | TNS4 | 84951 | 8 | 1 | 31 | |
| GSE54993 | TNS4 | 84951 | 3 | 4 | 63 | |
| GSE54994 | TNS4 | 84951 | 8 | 5 | 40 | |
| GSE60625 | TNS4 | 84951 | 4 | 0 | 7 | |
| GSE74703 | TNS4 | 84951 | 1 | 1 | 34 | |
| GSE74704 | TNS4 | 84951 | 5 | 1 | 14 | |
| TCGA | TNS4 | 84951 | 24 | 8 | 64 |
Total number of gains: 102; Total number of losses: 24; Total Number of normals: 362.
Somatic mutations of TNS4:
Generating mutation plots.
Highly correlated genes for TNS4:
Showing top 20/1379 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNS4 | LINGO1 | 0.784386 | 3 | 0 | 3 |
| TNS4 | ZAP70 | 0.774973 | 3 | 0 | 3 |
| TNS4 | SLC38A10 | 0.75764 | 3 | 0 | 3 |
| TNS4 | EPN1 | 0.727791 | 5 | 0 | 5 |
| TNS4 | ADAMTS14 | 0.727485 | 4 | 0 | 4 |
| TNS4 | COPB1 | 0.726186 | 3 | 0 | 3 |
| TNS4 | CERCAM | 0.725836 | 3 | 0 | 3 |
| TNS4 | ITGB4 | 0.72147 | 13 | 0 | 13 |
| TNS4 | CREB5 | 0.720907 | 3 | 0 | 3 |
| TNS4 | DHX33 | 0.711286 | 4 | 0 | 3 |
| TNS4 | STX16 | 0.708712 | 4 | 0 | 3 |
| TNS4 | OCIAD2 | 0.70527 | 8 | 0 | 6 |
| TNS4 | ZNF114 | 0.70152 | 4 | 0 | 4 |
| TNS4 | KLF10 | 0.699133 | 3 | 0 | 3 |
| TNS4 | EME1 | 0.696719 | 6 | 0 | 6 |
| TNS4 | PGM2L1 | 0.695452 | 4 | 0 | 3 |
| TNS4 | RTKN | 0.694194 | 8 | 0 | 7 |
| TNS4 | AJUBA | 0.69125 | 5 | 0 | 5 |
| TNS4 | PDGFC | 0.691012 | 3 | 0 | 3 |
| TNS4 | ITGB6 | 0.685387 | 3 | 0 | 3 |
For details and further investigation, click here
