LAMB3

 

Full name: laminin subunit beta 3 Alias Symbol: nicein-125kDa|kalinin-140kDa|BM600-125kDa
Type: protein-coding gene Cytoband: 1q32.2
Entrez ID: 3914 HGNC ID: HGNC:6490 Ensembl Gene: ENSG00000196878 OMIM ID: 150310
Drug and gene relationship at DGIdb

 

LAMB3 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa05200Pathways in cancer
hsa05222Small cell lung cancer

 

Expression of LAMB3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LAMB3 3914 209270_at 1.7775 0.0086
GSE20347 LAMB3 3914 209270_at 1.7018 0.0000
GSE23400 LAMB3 3914 209270_at 1.9775 0.0000
GSE26886 LAMB3 3914 209270_at 2.1631 0.0000
GSE29001 LAMB3 3914 209270_at 2.0192 0.0036
GSE38129 LAMB3 3914 209270_at 2.2694 0.0000
GSE45670 LAMB3 3914 209270_at 2.1892 0.0000
GSE53622 LAMB3 3914 113724 2.3237 0.0000
GSE53624 LAMB3 3914 113724 2.0301 0.0000
GSE63941 LAMB3 3914 209270_at 4.0530 0.0001
GSE77861 LAMB3 3914 209270_at 1.0280 0.0887
GSE97050 LAMB3 3914 A_33_P3338121 2.8412 0.1069
SRP007169 LAMB3 3914 RNAseq 2.1695 0.0000
SRP008496 LAMB3 3914 RNAseq 2.4199 0.0000
SRP064894 LAMB3 3914 RNAseq 2.7669 0.0000
SRP133303 LAMB3 3914 RNAseq 2.6541 0.0000
SRP159526 LAMB3 3914 RNAseq 1.8651 0.0000
SRP193095 LAMB3 3914 RNAseq 2.0452 0.0000
SRP219564 LAMB3 3914 RNAseq 3.2219 0.0033
TCGA LAMB3 3914 RNAseq 0.5786 0.0000

Upregulated datasets: 17; Downregulated datasets: 0.  

 

Survival by LAMB3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LAMB3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LAMB3 3914 11 0 19
GSE20123 LAMB3 3914 10 0 20
GSE43470 LAMB3 3914 7 0 36
GSE46452 LAMB3 3914 3 1 55
GSE47630 LAMB3 3914 15 0 25
GSE54993 LAMB3 3914 0 6 64
GSE54994 LAMB3 3914 14 0 39
GSE60625 LAMB3 3914 0 0 11
GSE74703 LAMB3 3914 7 0 29
GSE74704 LAMB3 3914 4 0 16
TCGA LAMB3 3914 44 3 49

Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.  

 

Somatic mutations of LAMB3:

 

Generating mutation plots.

 

Highly correlated genes for LAMB3:

 

Showing top 20/1636 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LAMB3LAMC20.81803613013
LAMB3CKS1B0.80695912012
LAMB3CDH30.80400311011
LAMB3PLAU0.79898512012
LAMB3PTK70.79312611011
LAMB3LAMA30.78004212011
LAMB3ITGB40.77845313013
LAMB3ITGA60.77512113012
LAMB3MFAP20.76481611011
LAMB3TTYH30.764559707
LAMB3TPX20.75779912012
LAMB3PLK10.74278611011
LAMB3FSCN10.74171413012
LAMB3UBE2T0.741194808
LAMB3OCIAD20.738648808
LAMB3CEP550.73832411010
LAMB3XPR10.737022707
LAMB3AURKB0.73389412011
LAMB3COL7A10.7320612011
LAMB3UBE2C0.73199212012

For details and further investigation, click here