| Full name: NLR family pyrin domain containing 2 | Alias Symbol: FLJ20510|PYPAF2|NBS1|PAN1|CLR19.9 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 55655 | HGNC ID: HGNC:22948 | Ensembl Gene: ENSG00000022556 | OMIM ID: 609364 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NLRP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLRP2 | 55655 | 221690_s_at | 0.2018 | 0.9456 | |
| GSE20347 | NLRP2 | 55655 | 221690_s_at | -0.6571 | 0.1407 | |
| GSE23400 | NLRP2 | 55655 | 221690_s_at | -0.0360 | 0.8635 | |
| GSE26886 | NLRP2 | 55655 | 221690_s_at | -1.2107 | 0.1846 | |
| GSE29001 | NLRP2 | 55655 | 221690_s_at | -1.1120 | 0.1467 | |
| GSE38129 | NLRP2 | 55655 | 221690_s_at | -0.3133 | 0.5195 | |
| GSE45670 | NLRP2 | 55655 | 221690_s_at | 0.7156 | 0.4141 | |
| GSE53622 | NLRP2 | 55655 | 47339 | -1.4670 | 0.0012 | |
| GSE53624 | NLRP2 | 55655 | 47339 | -1.5842 | 0.0000 | |
| GSE63941 | NLRP2 | 55655 | 221690_s_at | 2.3289 | 0.2010 | |
| GSE77861 | NLRP2 | 55655 | 221690_s_at | -0.1194 | 0.8931 | |
| GSE97050 | NLRP2 | 55655 | A_24_P213161 | -0.4447 | 0.4351 | |
| SRP007169 | NLRP2 | 55655 | RNAseq | -5.2389 | 0.0018 | |
| SRP133303 | NLRP2 | 55655 | RNAseq | -0.0949 | 0.9288 | |
| TCGA | NLRP2 | 55655 | RNAseq | -0.2570 | 0.6068 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by NLRP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLRP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLRP2 | 55655 | 3 | 4 | 23 | |
| GSE20123 | NLRP2 | 55655 | 3 | 3 | 24 | |
| GSE43470 | NLRP2 | 55655 | 3 | 11 | 29 | |
| GSE46452 | NLRP2 | 55655 | 45 | 1 | 13 | |
| GSE47630 | NLRP2 | 55655 | 8 | 6 | 26 | |
| GSE54993 | NLRP2 | 55655 | 17 | 4 | 49 | |
| GSE54994 | NLRP2 | 55655 | 4 | 13 | 36 | |
| GSE60625 | NLRP2 | 55655 | 9 | 0 | 2 | |
| GSE74703 | NLRP2 | 55655 | 3 | 7 | 26 | |
| GSE74704 | NLRP2 | 55655 | 3 | 1 | 16 | |
| TCGA | NLRP2 | 55655 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of NLRP2:
Generating mutation plots.
Highly correlated genes for NLRP2:
Showing all 7 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLRP2 | GPC2 | 0.706262 | 3 | 0 | 3 |
| NLRP2 | C11orf65 | 0.676638 | 3 | 0 | 3 |
| NLRP2 | DACH1 | 0.65959 | 3 | 0 | 3 |
| NLRP2 | ZMYND8 | 0.59131 | 3 | 0 | 3 |
| NLRP2 | PRRG1 | 0.544388 | 5 | 0 | 3 |
| NLRP2 | TBL3 | 0.539811 | 6 | 0 | 3 |
| NLRP2 | CLDN4 | 0.509188 | 5 | 0 | 3 |
For details and further investigation, click here
