| Full name: claudin 4 | Alias Symbol: CPE-R|WBSCR8|hCPE-R | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 1364 | HGNC ID: HGNC:2046 | Ensembl Gene: ENSG00000189143 | OMIM ID: 602909 |
| Drug and gene relationship at DGIdb | |||
CLDN4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN4 | 1364 | 201428_at | -0.7191 | 0.3542 | |
| GSE20347 | CLDN4 | 1364 | 201428_at | -1.0868 | 0.0001 | |
| GSE23400 | CLDN4 | 1364 | 201428_at | -1.1508 | 0.0000 | |
| GSE26886 | CLDN4 | 1364 | 201428_at | -1.0808 | 0.0008 | |
| GSE29001 | CLDN4 | 1364 | 201428_at | -1.7925 | 0.0007 | |
| GSE38129 | CLDN4 | 1364 | 201428_at | -0.3218 | 0.4089 | |
| GSE45670 | CLDN4 | 1364 | 201428_at | -0.1786 | 0.4942 | |
| GSE53622 | CLDN4 | 1364 | 87213 | -1.2466 | 0.0000 | |
| GSE53624 | CLDN4 | 1364 | 20116 | -1.6903 | 0.0000 | |
| GSE63941 | CLDN4 | 1364 | 201428_at | 3.7672 | 0.0035 | |
| GSE77861 | CLDN4 | 1364 | 201428_at | -0.0201 | 0.9647 | |
| GSE97050 | CLDN4 | 1364 | A_33_P3285545 | 0.5270 | 0.3573 | |
| SRP007169 | CLDN4 | 1364 | RNAseq | -2.2411 | 0.0000 | |
| SRP008496 | CLDN4 | 1364 | RNAseq | -2.5105 | 0.0000 | |
| SRP064894 | CLDN4 | 1364 | RNAseq | -2.4622 | 0.0000 | |
| SRP133303 | CLDN4 | 1364 | RNAseq | -1.1133 | 0.0028 | |
| SRP159526 | CLDN4 | 1364 | RNAseq | -1.5328 | 0.0491 | |
| SRP193095 | CLDN4 | 1364 | RNAseq | -0.4950 | 0.1031 | |
| SRP219564 | CLDN4 | 1364 | RNAseq | -1.9901 | 0.0784 | |
| TCGA | CLDN4 | 1364 | RNAseq | 0.7248 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 11.
Survival by CLDN4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN4 | 1364 | 14 | 1 | 15 | |
| GSE20123 | CLDN4 | 1364 | 14 | 1 | 15 | |
| GSE43470 | CLDN4 | 1364 | 3 | 2 | 38 | |
| GSE46452 | CLDN4 | 1364 | 12 | 0 | 47 | |
| GSE47630 | CLDN4 | 1364 | 7 | 2 | 31 | |
| GSE54993 | CLDN4 | 1364 | 2 | 7 | 61 | |
| GSE54994 | CLDN4 | 1364 | 14 | 3 | 36 | |
| GSE60625 | CLDN4 | 1364 | 0 | 0 | 11 | |
| GSE74703 | CLDN4 | 1364 | 3 | 1 | 32 | |
| GSE74704 | CLDN4 | 1364 | 8 | 1 | 11 | |
| TCGA | CLDN4 | 1364 | 45 | 7 | 44 |
Total number of gains: 122; Total number of losses: 25; Total Number of normals: 341.
Somatic mutations of CLDN4:
Generating mutation plots.
Highly correlated genes for CLDN4:
Showing top 20/849 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN4 | SPRR2A | 0.80971 | 3 | 0 | 3 |
| CLDN4 | NCCRP1 | 0.80405 | 3 | 0 | 3 |
| CLDN4 | SPRR2D | 0.801587 | 3 | 0 | 3 |
| CLDN4 | SPRR2F | 0.795303 | 3 | 0 | 3 |
| CLDN4 | TMPRSS11A | 0.794161 | 3 | 0 | 3 |
| CLDN4 | SPRR2E | 0.788113 | 3 | 0 | 3 |
| CLDN4 | RAB25 | 0.772158 | 9 | 0 | 9 |
| CLDN4 | TACSTD2 | 0.771061 | 9 | 0 | 9 |
| CLDN4 | SPATA19 | 0.768725 | 4 | 0 | 4 |
| CLDN4 | ELF3 | 0.763823 | 11 | 0 | 10 |
| CLDN4 | MAL2 | 0.756625 | 5 | 0 | 5 |
| CLDN4 | SCNN1A | 0.756325 | 10 | 0 | 10 |
| CLDN4 | CYP2C18 | 0.752797 | 8 | 0 | 8 |
| CLDN4 | KLK13 | 0.7498 | 8 | 0 | 8 |
| CLDN4 | EPHA1 | 0.747849 | 11 | 0 | 10 |
| CLDN4 | OTOP3 | 0.747099 | 3 | 0 | 3 |
| CLDN4 | RHCG | 0.746154 | 8 | 0 | 8 |
| CLDN4 | NEBL | 0.742841 | 10 | 0 | 10 |
| CLDN4 | CEACAM6 | 0.739634 | 10 | 0 | 9 |
| CLDN4 | EVPL | 0.739393 | 11 | 0 | 10 |
For details and further investigation, click here
