| Full name: dachshund family transcription factor 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q21.33 | ||
| Entrez ID: 1602 | HGNC ID: HGNC:2663 | Ensembl Gene: ENSG00000276644 | OMIM ID: 603803 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of DACH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DACH1 | 1602 | 228915_at | -0.4560 | 0.5967 | |
| GSE20347 | DACH1 | 1602 | 205471_s_at | -0.1472 | 0.1148 | |
| GSE23400 | DACH1 | 1602 | 205472_s_at | 0.0026 | 0.8974 | |
| GSE26886 | DACH1 | 1602 | 228915_at | 1.3806 | 0.0287 | |
| GSE29001 | DACH1 | 1602 | 205471_s_at | -0.0732 | 0.8237 | |
| GSE38129 | DACH1 | 1602 | 205471_s_at | -0.2323 | 0.1191 | |
| GSE45670 | DACH1 | 1602 | 205471_s_at | -0.6411 | 0.2725 | |
| GSE53622 | DACH1 | 1602 | 16233 | -0.4693 | 0.0019 | |
| GSE53624 | DACH1 | 1602 | 16233 | -0.3374 | 0.0263 | |
| GSE63941 | DACH1 | 1602 | 205471_s_at | -0.1404 | 0.7364 | |
| GSE77861 | DACH1 | 1602 | 205471_s_at | 0.0643 | 0.6676 | |
| GSE97050 | DACH1 | 1602 | A_33_P3316786 | -0.0178 | 0.9524 | |
| SRP133303 | DACH1 | 1602 | RNAseq | 0.1756 | 0.7446 | |
| SRP159526 | DACH1 | 1602 | RNAseq | 1.2869 | 0.0280 | |
| SRP219564 | DACH1 | 1602 | RNAseq | -0.3007 | 0.6755 | |
| TCGA | DACH1 | 1602 | RNAseq | -0.6233 | 0.0477 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DACH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DACH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DACH1 | 1602 | 3 | 12 | 15 | |
| GSE20123 | DACH1 | 1602 | 3 | 11 | 16 | |
| GSE43470 | DACH1 | 1602 | 4 | 10 | 29 | |
| GSE46452 | DACH1 | 1602 | 2 | 31 | 26 | |
| GSE47630 | DACH1 | 1602 | 3 | 26 | 11 | |
| GSE54993 | DACH1 | 1602 | 11 | 3 | 56 | |
| GSE54994 | DACH1 | 1602 | 4 | 13 | 36 | |
| GSE60625 | DACH1 | 1602 | 0 | 3 | 8 | |
| GSE74703 | DACH1 | 1602 | 3 | 8 | 25 | |
| GSE74704 | DACH1 | 1602 | 1 | 10 | 9 | |
| TCGA | DACH1 | 1602 | 12 | 34 | 50 |
Total number of gains: 46; Total number of losses: 161; Total Number of normals: 281.
Somatic mutations of DACH1:
Generating mutation plots.
Highly correlated genes for DACH1:
Showing top 20/63 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DACH1 | PRR15 | 0.738795 | 3 | 0 | 3 |
| DACH1 | KIAA1671 | 0.715072 | 4 | 0 | 4 |
| DACH1 | C19orf73 | 0.690547 | 3 | 0 | 3 |
| DACH1 | IFT27 | 0.686465 | 3 | 0 | 3 |
| DACH1 | CCL13 | 0.685121 | 3 | 0 | 3 |
| DACH1 | TRDMT1 | 0.68265 | 4 | 0 | 3 |
| DACH1 | CLDN3 | 0.660699 | 3 | 0 | 3 |
| DACH1 | NLRP2 | 0.65959 | 3 | 0 | 3 |
| DACH1 | MYBPC1 | 0.656957 | 3 | 0 | 3 |
| DACH1 | GRB7 | 0.654271 | 3 | 0 | 3 |
| DACH1 | L3MBTL1 | 0.650995 | 3 | 0 | 3 |
| DACH1 | CHRNA2 | 0.633289 | 3 | 0 | 3 |
| DACH1 | JAKMIP2 | 0.627164 | 7 | 0 | 4 |
| DACH1 | ADRA2A | 0.625021 | 4 | 0 | 3 |
| DACH1 | SLC27A5 | 0.621373 | 4 | 0 | 3 |
| DACH1 | ERC2 | 0.621322 | 4 | 0 | 3 |
| DACH1 | RTCB | 0.619187 | 3 | 0 | 3 |
| DACH1 | UPK1B | 0.615448 | 3 | 0 | 3 |
| DACH1 | DDX43 | 0.608953 | 3 | 0 | 3 |
| DACH1 | TXN2 | 0.608209 | 5 | 0 | 3 |
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