| Full name: late cornified envelope 2A | Alias Symbol: LEP9 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 353139 | HGNC ID: HGNC:29469 | Ensembl Gene: ENSG00000187173 | OMIM ID: 612609 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LCE2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | LCE2A | 353139 | 64671 | 1.1163 | 0.0000 | |
| GSE53624 | LCE2A | 353139 | 64671 | 1.6988 | 0.0000 | |
| TCGA | LCE2A | 353139 | RNAseq | 3.0897 | 0.0543 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LCE2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LCE2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LCE2A | 353139 | 15 | 0 | 15 | |
| GSE20123 | LCE2A | 353139 | 15 | 0 | 15 | |
| GSE43470 | LCE2A | 353139 | 6 | 2 | 35 | |
| GSE46452 | LCE2A | 353139 | 3 | 1 | 55 | |
| GSE47630 | LCE2A | 353139 | 15 | 0 | 25 | |
| GSE54993 | LCE2A | 353139 | 0 | 4 | 66 | |
| GSE54994 | LCE2A | 353139 | 15 | 0 | 38 | |
| GSE60625 | LCE2A | 353139 | 0 | 0 | 11 | |
| GSE74703 | LCE2A | 353139 | 6 | 1 | 29 | |
| GSE74704 | LCE2A | 353139 | 7 | 0 | 13 | |
| TCGA | LCE2A | 353139 | 39 | 2 | 55 |
Total number of gains: 121; Total number of losses: 10; Total Number of normals: 357.
Somatic mutations of LCE2A:
Generating mutation plots.
Highly correlated genes for LCE2A:
Showing all 6 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LCE2A | LCE2B | 0.862132 | 3 | 0 | 3 |
| LCE2A | LCE2D | 0.761073 | 3 | 0 | 3 |
| LCE2A | LCE6A | 0.725247 | 3 | 0 | 3 |
| LCE2A | SPRR2G | 0.608839 | 3 | 0 | 3 |
| LCE2A | ASPRV1 | 0.600454 | 3 | 0 | 3 |
| LCE2A | LCE1B | 0.563911 | 3 | 0 | 3 |
For details and further investigation, click here
