| Full name: late cornified envelope 2B | Alias Symbol: LEP10|XP5 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 26239 | HGNC ID: HGNC:16610 | Ensembl Gene: ENSG00000159455 | OMIM ID: 612610 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LCE2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LCE2B | 26239 | 207710_at | 0.0308 | 0.9200 | |
| GSE20347 | LCE2B | 26239 | 207710_at | -0.0480 | 0.5041 | |
| GSE23400 | LCE2B | 26239 | 207710_at | 0.0073 | 0.7961 | |
| GSE26886 | LCE2B | 26239 | 207710_at | 0.1334 | 0.1827 | |
| GSE29001 | LCE2B | 26239 | 207710_at | -0.0978 | 0.4365 | |
| GSE38129 | LCE2B | 26239 | 207710_at | -0.1049 | 0.0865 | |
| GSE45670 | LCE2B | 26239 | 207710_at | 0.3811 | 0.1932 | |
| GSE53622 | LCE2B | 26239 | 13792 | 1.1382 | 0.0000 | |
| GSE53624 | LCE2B | 26239 | 13792 | 1.2787 | 0.0002 | |
| GSE63941 | LCE2B | 26239 | 207710_at | 0.0683 | 0.6255 | |
| GSE77861 | LCE2B | 26239 | 207710_at | -0.0646 | 0.6795 | |
| GSE97050 | LCE2B | 26239 | A_24_P207828 | 0.6217 | 0.4302 | |
| TCGA | LCE2B | 26239 | RNAseq | 1.4500 | 0.3763 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LCE2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LCE2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LCE2B | 26239 | 15 | 0 | 15 | |
| GSE20123 | LCE2B | 26239 | 15 | 0 | 15 | |
| GSE43470 | LCE2B | 26239 | 6 | 2 | 35 | |
| GSE46452 | LCE2B | 26239 | 3 | 1 | 55 | |
| GSE47630 | LCE2B | 26239 | 15 | 0 | 25 | |
| GSE54993 | LCE2B | 26239 | 0 | 4 | 66 | |
| GSE54994 | LCE2B | 26239 | 15 | 0 | 38 | |
| GSE60625 | LCE2B | 26239 | 0 | 0 | 11 | |
| GSE74703 | LCE2B | 26239 | 6 | 1 | 29 | |
| GSE74704 | LCE2B | 26239 | 7 | 0 | 13 | |
| TCGA | LCE2B | 26239 | 39 | 2 | 55 |
Total number of gains: 121; Total number of losses: 10; Total Number of normals: 357.
Somatic mutations of LCE2B:
Generating mutation plots.
Highly correlated genes for LCE2B:
Showing top 20/123 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LCE2B | LCE2A | 0.862132 | 3 | 0 | 3 |
| LCE2B | LCE2D | 0.777007 | 4 | 0 | 4 |
| LCE2B | LCE6A | 0.658521 | 3 | 0 | 3 |
| LCE2B | MED12L | 0.654786 | 3 | 0 | 3 |
| LCE2B | PRR9 | 0.643033 | 3 | 0 | 3 |
| LCE2B | ASPRV1 | 0.629084 | 5 | 0 | 5 |
| LCE2B | ATXN3L | 0.622378 | 4 | 0 | 3 |
| LCE2B | MUCL1 | 0.619127 | 4 | 0 | 4 |
| LCE2B | RNF185-AS1 | 0.618797 | 4 | 0 | 3 |
| LCE2B | DCC | 0.617567 | 4 | 0 | 3 |
| LCE2B | DNAH11 | 0.616575 | 3 | 0 | 3 |
| LCE2B | PKLR | 0.612597 | 3 | 0 | 3 |
| LCE2B | LMAN1L | 0.610363 | 3 | 0 | 3 |
| LCE2B | REEP2 | 0.605904 | 6 | 0 | 5 |
| LCE2B | NANOS3 | 0.605323 | 4 | 0 | 3 |
| LCE2B | FOXN3-AS2 | 0.60364 | 3 | 0 | 3 |
| LCE2B | ATP4B | 0.603044 | 3 | 0 | 3 |
| LCE2B | AMHR2 | 0.592413 | 4 | 0 | 4 |
| LCE2B | LOR | 0.589609 | 6 | 0 | 4 |
| LCE2B | CYP17A1 | 0.589541 | 5 | 0 | 4 |
For details and further investigation, click here
