PKD1

 

Full name: polycystin 1, transient receptor potential channel interacting Alias Symbol: PBP|Pc-1|TRPP1
Type: protein-coding gene Cytoband: 16p13.3
Entrez ID: 5310 HGNC ID: HGNC:9008 Ensembl Gene: ENSG00000008710 OMIM ID: 601313
Drug and gene relationship at DGIdb

 

Expression of PKD1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE53622 PKD1 5310 41047 -0.0653 0.5196
GSE53624 PKD1 5310 41047 0.1893 0.0198
GSE97050 PKD1 A_21_P0011417 -0.2173 0.3645
SRP007169 PKD1 5310 RNAseq 0.5547 0.1229
SRP008496 PKD1 5310 RNAseq 0.7748 0.0070
SRP064894 PKD1 5310 RNAseq -0.0701 0.8288
SRP133303 PKD1 5310 RNAseq -0.1806 0.3694
SRP159526 PKD1 5310 RNAseq -0.1524 0.5695
SRP193095 PKD1 5310 RNAseq 0.5954 0.0000
SRP219564 PKD1 5310 RNAseq -0.0419 0.9344
TCGA PKD1 5310 RNAseq -0.2000 0.0005

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PKD1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PKD1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PKD1 5310 5 5 20
GSE20123 PKD1 5310 5 4 21
GSE43470 PKD1 5310 4 7 32
GSE46452 PKD1 5310 38 1 20
GSE47630 PKD1 5310 13 6 21
GSE54993 PKD1 5310 3 5 62
GSE54994 PKD1 5310 5 9 39
GSE60625 PKD1 5310 4 0 7
GSE74703 PKD1 5310 4 5 27
GSE74704 PKD1 5310 3 2 15
TCGA PKD1 5310 19 14 63

Total number of gains: 103; Total number of losses: 58; Total Number of normals: 327.  

 

Somatic mutations of PKD1:

 

Generating mutation plots.

 

Highly correlated genes for PKD1:

 

Showing all 8 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PKD1TAZ0.711672303
PKD1ZNF6920.694766303
PKD1PPP1R12C0.656955303
PKD1TAOK20.651941303
PKD1WDR60.617964403
PKD1CSAD0.587931403
PKD1TSC20.582389403
PKD1TTLL30.572813303

For details and further investigation, click here