| Full name: protein phosphatase 1 regulatory subunit 12C | Alias Symbol: DKFZP434D0412|p84|MBS85|p85|AAVS1 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 54776 | HGNC ID: HGNC:14947 | Ensembl Gene: ENSG00000125503 | OMIM ID: 613245 |
| Drug and gene relationship at DGIdb | |||
PPP1R12C involved pathways:
Expression of PPP1R12C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R12C | 54776 | 223152_at | -0.3603 | 0.5862 | |
| GSE26886 | PPP1R12C | 54776 | 223152_at | 0.6532 | 0.0004 | |
| GSE45670 | PPP1R12C | 54776 | 223152_at | -0.1671 | 0.1534 | |
| GSE53622 | PPP1R12C | 54776 | 64156 | -0.7561 | 0.0000 | |
| GSE53624 | PPP1R12C | 54776 | 64156 | -0.6353 | 0.0000 | |
| GSE63941 | PPP1R12C | 54776 | 223152_at | -0.3026 | 0.2973 | |
| GSE77861 | PPP1R12C | 54776 | 223152_at | 0.0769 | 0.6891 | |
| GSE97050 | PPP1R12C | 54776 | A_33_P3521643 | -0.9973 | 0.1057 | |
| SRP007169 | PPP1R12C | 54776 | RNAseq | -0.7346 | 0.0410 | |
| SRP008496 | PPP1R12C | 54776 | RNAseq | -0.5281 | 0.0084 | |
| SRP064894 | PPP1R12C | 54776 | RNAseq | -0.0407 | 0.8565 | |
| SRP133303 | PPP1R12C | 54776 | RNAseq | -0.1695 | 0.6019 | |
| SRP159526 | PPP1R12C | 54776 | RNAseq | -0.4443 | 0.0940 | |
| SRP193095 | PPP1R12C | 54776 | RNAseq | 0.1951 | 0.1909 | |
| SRP219564 | PPP1R12C | 54776 | RNAseq | -0.8083 | 0.2600 | |
| TCGA | PPP1R12C | 54776 | RNAseq | -0.3868 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP1R12C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R12C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R12C | 54776 | 3 | 4 | 23 | |
| GSE20123 | PPP1R12C | 54776 | 3 | 3 | 24 | |
| GSE43470 | PPP1R12C | 54776 | 3 | 11 | 29 | |
| GSE46452 | PPP1R12C | 54776 | 45 | 1 | 13 | |
| GSE47630 | PPP1R12C | 54776 | 8 | 6 | 26 | |
| GSE54993 | PPP1R12C | 54776 | 17 | 4 | 49 | |
| GSE54994 | PPP1R12C | 54776 | 4 | 13 | 36 | |
| GSE60625 | PPP1R12C | 54776 | 9 | 0 | 2 | |
| GSE74703 | PPP1R12C | 54776 | 3 | 7 | 26 | |
| GSE74704 | PPP1R12C | 54776 | 3 | 1 | 16 | |
| TCGA | PPP1R12C | 54776 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of PPP1R12C:
Generating mutation plots.
Highly correlated genes for PPP1R12C:
Showing top 20/512 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R12C | HMX1 | 0.850927 | 3 | 0 | 3 |
| PPP1R12C | PYGM | 0.821222 | 3 | 0 | 3 |
| PPP1R12C | GRIK3 | 0.792291 | 3 | 0 | 3 |
| PPP1R12C | RPRM | 0.786329 | 3 | 0 | 3 |
| PPP1R12C | IGFALS | 0.780635 | 3 | 0 | 3 |
| PPP1R12C | TRIM17 | 0.779926 | 3 | 0 | 3 |
| PPP1R12C | HECTD2 | 0.774965 | 3 | 0 | 3 |
| PPP1R12C | MGAT5B | 0.773154 | 3 | 0 | 3 |
| PPP1R12C | DNAJB8 | 0.77087 | 3 | 0 | 3 |
| PPP1R12C | STAC3 | 0.763809 | 3 | 0 | 3 |
| PPP1R12C | NCAM1 | 0.758961 | 3 | 0 | 3 |
| PPP1R12C | ZNF781 | 0.756024 | 3 | 0 | 3 |
| PPP1R12C | MAPK8IP2 | 0.751796 | 3 | 0 | 3 |
| PPP1R12C | RASL10B | 0.748055 | 4 | 0 | 4 |
| PPP1R12C | SHARPIN | 0.747309 | 3 | 0 | 3 |
| PPP1R12C | RIIAD1 | 0.743428 | 3 | 0 | 3 |
| PPP1R12C | SLC29A4 | 0.739915 | 3 | 0 | 3 |
| PPP1R12C | SLC2A4 | 0.739713 | 3 | 0 | 3 |
| PPP1R12C | C20orf141 | 0.733484 | 3 | 0 | 3 |
| PPP1R12C | CDH2 | 0.732573 | 3 | 0 | 3 |
For details and further investigation, click here
