TSC2

 

Full name: TSC complex subunit 2 Alias Symbol: tuberin|LAM|PPP1R160
Type: protein-coding gene Cytoband: 16p13.3
Entrez ID: 7249 HGNC ID: HGNC:12363 Ensembl Gene: ENSG00000103197 OMIM ID: 191092
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 17/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TSC2 involved pathways:

KEGG pathway Description View
hsa04072Phospholipase D signaling pathway
hsa04115p53 signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04910Insulin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa05231Choline metabolism in cancer

 

Expression of TSC2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TSC2 7249 215735_s_at 0.1903 0.6266
GSE20347 TSC2 7249 215735_s_at -0.1259 0.4312
GSE23400 TSC2 7249 215735_s_at -0.0086 0.9184
GSE26886 TSC2 7249 215735_s_at 0.2481 0.3494
GSE29001 TSC2 7249 215735_s_at 0.0515 0.8699
GSE38129 TSC2 7249 215735_s_at -0.1818 0.1032
GSE45670 TSC2 7249 215735_s_at 0.1141 0.5265
GSE53622 TSC2 7249 80628 0.0315 0.6566
GSE53624 TSC2 7249 80628 0.1385 0.0191
GSE63941 TSC2 7249 215735_s_at 0.5728 0.0999
GSE77861 TSC2 7249 215735_s_at 0.0040 0.9908
GSE97050 TSC2 7249 A_23_P66110 0.3132 0.1939
SRP007169 TSC2 7249 RNAseq 0.9978 0.0444
SRP008496 TSC2 7249 RNAseq 0.6811 0.0589
SRP064894 TSC2 7249 RNAseq -0.1623 0.2994
SRP133303 TSC2 7249 RNAseq -0.1960 0.1865
SRP159526 TSC2 7249 RNAseq -0.1629 0.3435
SRP193095 TSC2 7249 RNAseq 0.1282 0.3441
SRP219564 TSC2 7249 RNAseq 0.0329 0.9119
TCGA TSC2 7249 RNAseq -0.1582 0.0001

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TSC2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TSC2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TSC2 7249 5 5 20
GSE20123 TSC2 7249 5 4 21
GSE43470 TSC2 7249 4 7 32
GSE46452 TSC2 7249 38 1 20
GSE47630 TSC2 7249 13 6 21
GSE54993 TSC2 7249 3 5 62
GSE54994 TSC2 7249 5 9 39
GSE60625 TSC2 7249 4 0 7
GSE74703 TSC2 7249 4 5 27
GSE74704 TSC2 7249 3 2 15
TCGA TSC2 7249 19 14 63

Total number of gains: 103; Total number of losses: 58; Total Number of normals: 327.  

 

Somatic mutations of TSC2:

 

Generating mutation plots.

 

Highly correlated genes for TSC2:

 

Showing top 20/72 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TSC2C7orf260.688878404
TSC2MANEAL0.682066303
TSC2THAP70.646853303
TSC2UBXN110.646459504
TSC2TOE10.644918303
TSC2MPV17L20.643018303
TSC2SLC41A30.64039503
TSC2TKTL10.62978303
TSC2EIF3B0.622434303
TSC2IRGQ0.62103403
TSC2RFXANK0.606203403
TSC2PYGO20.604783403
TSC2ALKBH20.60405403
TSC2GPX40.603174403
TSC2MIB20.597055504
TSC2SETD1B0.596919505
TSC2ERAL10.589549303
TSC2MLF20.58748504
TSC2ARHGAP230.587348403
TSC2RITA10.582667403

For details and further investigation, click here